4-CHLORO-3-IODO-PYRIDIN-2-YLAMINE
- Product Name
- 4-CHLORO-3-IODO-PYRIDIN-2-YLAMINE
- CAS No.
- 417721-69-8
- Chemical Name
- 4-CHLORO-3-IODO-PYRIDIN-2-YLAMINE
- Synonyms
- 4-chloro-3-iodopyridin-2-amine;4-Chloro-3-iodo-2-pyridinamine;2-Amino-4-chloro-3-iodopyridine;2-PyridinaMine, 4-chloro-3-iodo-;2-Amino-4-chloro-3-iodopyridine,96%;4-Chloro-3-iodopyridin-2-amine 95+%;4-CHLORO-3-IODO-PYRIDIN-2-YLAMINE ISO 9001：2015 REACH
- CBNumber
- CB11229296
- Molecular Formula
- C5H4ClIN2
- Formula Weight
- 254.46
- MOL File
- 417721-69-8.mol
4-CHLORO-3-IODO-PYRIDIN-2-YLAMINE Property
- Melting point:
- 111-113℃
- Boiling point:
- 319.8±42.0 °C(Predicted)
- Density
- 2.139±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 3.40±0.47(Predicted)
- form
- solid
- color
- Yellow
- Sensitive
- Light Sensitive
- InChI
- InChI=1S/C5H4ClIN2/c6-3-1-2-9-5(8)4(3)7/h1-2H,(H2,8,9)
- InChIKey
- BWMULFKDCVPGNF-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=CC(Cl)=C1I
- CAS DataBase Reference
- 417721-69-8
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36/37
- RIDADR
- 2811
- WGK Germany
- 3
- HazardClass
- IRRITANT
- PackingGroup
- Ⅲ
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- ADE000408
- Product name
- 4-Chloro-3-iodo-pyridin-2-ylamine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $497
- Updated
- 2025/07/31
- Product number
- C367568
- Product name
- 4-Chloro-3-iodopyridin-2-amine
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 026188
- Product name
- 4-Chloro-3-iodo-pyridin-2-ylamine
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- FC42195
- Product name
- 4-Chloro-3-iodopyridin-2-amine
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FC42195
- Product name
- 4-Chloro-3-iodopyridin-2-amine
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
4-CHLORO-3-IODO-PYRIDIN-2-YLAMINE Chemical Properties,Usage,Production
Synthesis
868733-96-4
417721-69-8
General procedure for the synthesis of 4-chloro-3-iodopyridin-2-ylamine from tert-butyl 4-chloro-3-iodopyridin-2-ylcarbamate: tert-butyl 4-chloro-3-iodopyridin-2-ylcarbamate (5.6 g, 15.8 mmol) was suspended in 48% hydrobromic acid and heated at 100 °C for 10 min until the solution clarified. Upon completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched by the addition of crushed ice, followed by adjusting the pH to basic with 6 M sodium hydroxide solution. The precipitated white solid product was collected by vacuum filtration, washed with water and partially drained on a Büchner funnel. The crude product was dissolved in tetrahydrofuran and the solution was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 4-chloro-3-iodopyridin-2-ylamine (3.7 g, 93% yield) as a white solid. The product was characterized by 1H NMR (DMSO-d6): δ 7.84 (d, 1H, J = 5.1 Hz), 6.73 (d, 1H, J = 5.6 Hz), 6.51 (br s, 2H); mass spectrum (ESI+): m/z 254.97 ([M + H]+).
References
[1] Molecules, 2012, vol. 17, # 9, p. 10683 - 10707,25
[2] Molecules, 2012, vol. 17, # 9, p. 10683 - 10707
[3] Patent: US2005/245530, 2005, A1. Location in patent: Page/Page column 46
[4] Journal of Medicinal Chemistry, 2009, vol. 52, # 5, p. 1251 - 1254
[5] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 1, p. 114 - 120
4-CHLORO-3-IODO-PYRIDIN-2-YLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-CHLORO-3-IODO-PYRIDIN-2-YLAMINE manufacturers
- Product
- 4-CHLORO-3-IODO-PYRIDIN-2-YLAMINE 417721-69-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-13
- Product
- 4-CHLORO-3-IODO-PYRIDIN-2-YLAMINE 417721-69-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-01
- Product
- 4-CHLORO-3-IODO-PYRIDIN-2-YLAMINE 417721-69-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09