1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one

Product Name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one
CAS No.: 5627-05-4
Chemical Name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one
Synonyms: dihydrouridine;6-Dihydrouridine;Uridine, 5,6-dihydro-;5,6-Dihydrouridine, 10 mM in DMSO;Uridine Impurity 28（5,6-Dihydrouridine）;5,6-Dihydrouridine RNA-modified nucleoside D;1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one;1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)dihydropyrimidine-2,4(1H,3H)-dione
CBNumber: CB11235574
Molecular Formula: C9H14N2O6
Formula Weight: 246.22
MOL File: 5627-05-4.mol

More

Less

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Property

Density: 1.614±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 16 mg/ml; DMSO: 10 mg/ml; PBS (pH 7.2): 5 mg/ml
form: A crystalline solid
pka: 12.40±0.20(Predicted)
color: White to off-white
PH: ～11
λmax: 208 (in H2O)
Stability:: Hygroscopic

More

Less

Safety

HS Code: 2934999090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: D449668
Product name: 5,6-Dihydrouridine
Packaging: 100mg
Price: $800
Updated: 2021/12/16

TRC

Product number: D449668
Product name: 5,6-Dihydrouridine
Packaging: 250mg
Price: $1755
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H12-1-03
Product name: 5,6-Dihydrouridine
Purity: 95%
Packaging: 250mg
Price: $55
Updated: 2021/12/16

ChemScene

Product number: CS-0059431
Product name: 5,6-Dihydrouridine
Purity: 99.87%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: NUC0001384
Product name: 5,6-DIHYDRO-URIDINE
Purity: 95.00%
Packaging: 5MG
Price: $501.22
Updated: 2021/12/16

More

Less

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Chemical Properties,Usage,Production

Uses

5,6-Dihydrouridine is an intermediate used in the synthesis of 3,4,5,6-Tetrahydrouridine (>80%) (T310250), which is a derivative of Uridine (U829910). Tetrahydrouridine (THU) is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA.

Definition

ChEBI: The uridine derivative obtained by formal hydrogenation of the endocyclic double bond in the uracil ring.

IC 50

Human Endogenous Metabolite

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Suppliers

China 40 Germany 1 India 2 United Kingdom 1 United States 7 Global 51

Panaishen (Henan) Pharmaceutical Science and Technology Co. , Ltd.

Tel: 0371-65325800 13700860222
Email: haifeng.zhang@pannacean.com
Country: China
ProdList: 705
Advantage: 58

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Shandong Xiya Chemical Co., Ltd

Tel: 13355009207 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

Zhengzhou GranLen pharmaceutical Technology Co., Ltd.

Tel: 0371-85513397
Email: info@granlen.com
Country: China
ProdList: 497
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 40000
Advantage: 60

Beijing Qinling Mountains Pharmaceutical Co., Ltd.

Tel: 010-61241352 18901327973
Email: 834537306@qq.com
Country: China
ProdList: 530
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 18626450290
Email: yftan@aikonchem.com
Country: China
ProdList: 16676
Advantage: 50

Lanzhou Angeli Biochemical Technology Co., Ltd.

Tel: 0931-8235634 13321316780
Fax: +86(931) 4873122
Email: 1455540579@qq.com
Country: China
ProdList: 958
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

5627-05-4, 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-oneRelated Search:

dihydrouridine

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one

Uridine, 5,6-dihydro-

Uridine Impurity 28（5,6-Dihydrouridine）

6-Dihydrouridine

5,6-Dihydrouridine RNA-modified nucleoside D

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)dihydropyrimidine-2,4(1H,3H)-dione

5,6-Dihydrouridine, 10 mM in DMSO

5627-05-4