1H-Indole, 2,6-dimethyl-
- Product Name
- 1H-Indole, 2,6-dimethyl-
- CAS No.
- 5649-36-5
- Chemical Name
- 1H-Indole, 2,6-dimethyl-
- Synonyms
- 2,6-DiMethyl-1H-Indole;1H-Indole, 2,6-dimethyl-
- CBNumber
- CB11239244
- Molecular Formula
- C10H11N
- Formula Weight
- 145.2
- MOL File
- 5649-36-5.mol
1H-Indole, 2,6-dimethyl- Property
- Melting point:
- 82.5°C (estimate)
- Boiling point:
- 273.05°C
- Density
- 1.0641 (estimate)
- refractive index
- 1.6030 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 17.93±0.30(Predicted)
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2933998090
N-Bromosuccinimide Price
- Product number
- FD141688
- Product name
- 2,6-Dimethyl-1H-indole
- Packaging
- 50mg
- Price
- $62
- Updated
- 2021/12/16
- Product number
- FD141688
- Product name
- 2,6-Dimethyl-1H-indole
- Packaging
- 100mg
- Price
- $108
- Updated
- 2021/12/16
- Product number
- Z4891
- Product name
- 2,6-Dimethyl-1H-indole
- Packaging
- 250mg
- Price
- $131
- Updated
- 2021/12/16
- Product number
- OR929350
- Product name
- 2,6-Dimethyl-1H-indole
- Purity
- 95%
- Packaging
- 1g
- Price
- $300
- Updated
- 2021/12/16
- Product number
- FD141688
- Product name
- 2,6-Dimethyl-1H-indole
- Packaging
- 500mg
- Price
- $375
- Updated
- 2021/12/16
1H-Indole, 2,6-dimethyl- Chemical Properties,Usage,Production
Synthesis
67-64-1
108-44-1
5649-36-5
General procedure for the synthesis of 2,6-dimethyl-1H-indole (VI) from acetone and 3-methylaniline: in a reaction tube, 3-methylaniline (5.00 g, 0.046 mol), anhydrous copper(II) acetate (18.6 g, 0.093 mol), and palladium(II) acetate (0.208 g, 0.930 mmol) were dissolved in a mixture of acetone (25 mL) and dimethyl sulfoxide (25 mL) in a mixed solution and the reaction was heated at 90 °C for 18 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was poured into cold water and extracted with ethyl acetate (2 x 250 mL). The organic layer was separated and washed sequentially with water and brine. The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (100-200 mesh) with gradient elution of ethyl acetate/hexane to afford the target compound VI (1.0 g, 15% yield).1H NMR (400 MHz, CDCl3): δ 10.70 (s, 1H), 7.23 (d, J = 8.00 Hz, 1H), 7.02 (s, 1H), 6.72 (d J = 7.8 Hz, 1H), 6.01 (s, 1H), 2.34 (s, 6H); MS (ESI, positive mode) m/z 146 ([M+H]+).
References
[1] Patent: WO2015/73528, 2015, A1. Location in patent: Page/Page column 102
1H-Indole, 2,6-dimethyl- Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Indole, 2,6-dimethyl- Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 1H-Indole, 2,6-dimethyl- manufacturers
- Product
- 1H-Indole, 2,6-dimethyl- 5649-36-5
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-09