2-AMINO-4-FLUOROBENZONITRILE
Uses- Product Name
- 2-AMINO-4-FLUOROBENZONITRILE
- CAS No.
- 80517-22-2
- Chemical Name
- 2-AMINO-4-FLUOROBENZONITRILE
- Synonyms
- 4-Fluoroanthranilonitrile;Amino-4-fluorobenzonitrile;2-Amino-4-fluorobenzonitrile;Benzonitrile, 2-amino-4-fluoro-;4-Fluoroanthranilonitrile, 2-Cyano-5-fluoroaniline
- CBNumber
- CB11263751
- Molecular Formula
- C7H5FN2
- Formula Weight
- 136.13
- MOL File
- 80517-22-2.mol
2-AMINO-4-FLUOROBENZONITRILE Property
- Melting point:
- 102.2 °C (decomp)
- Boiling point:
- 284.7±25.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- crystals
- pka
- 0.80±0.10(Predicted)
- color
- Light purple
Safety
- HazardClass
- TOXIC
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A898183
- Product name
- 2-Amino-4-fluorobenzonitrile
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FA67713
- Product name
- 2-Amino-4-fluorobenzonitrile
- Packaging
- 25g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FA67713
- Product name
- 2-Amino-4-fluorobenzonitrile
- Packaging
- 50g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- HCH0002679
- Product name
- 2-AMINO-4-FLUOROBENZONITRILE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $130.2
- Updated
- 2021/12/16
- Product number
- 066865
- Product name
- 2-Amino-4-fluorobenzonitrile
- Purity
- 98%
- Packaging
- 25g
- Price
- $144
- Updated
- 2021/12/16
2-AMINO-4-FLUOROBENZONITRILE Chemical Properties,Usage,Production
Uses
2-Amino-4-fluorobenzonitrile is a useful research chemical for organic synthesis and other chemical processes.
Synthesis
3939-09-1
80517-22-2
53312-80-4
Using 2,4-difluorobenzonitrile (2.78 g, 20 mmol) and 3,4,5-trimethoxybenzylamine (3.94 g, 20 mmol) as raw material, the two were mixed and heated at 140 °C for 40 min. After completion of the reaction, the mixture was cooled to room temperature and subsequently dissolved in trifluoroacetic acid (TFA, 20 mL) and stirred at room temperature overnight. Afterwards, the mixture was concentrated using a rotary evaporator and subsequently partitioned between 1N NaOH solution (~100 mL, adjusted to alkaline) and ethyl acetate (100 mL). After separation of the organic layer, the aqueous layer was extracted with additional ethyl acetate (100 mL). All organic layers were combined, washed with brine (50 mL), dried over anhydrous magnesium sulfate (MgSO4) and concentrated to give an oil. Separation of the mixture by column chromatography (eluent: 10% to 40% hexane solution of ethyl acetate) gave two well separated isomeric products. Further concentration gave 4-amino-2-fluorobenzonitrile (1.07 g, 39% yield) as a white solid. The structure of the product was confirmed by LC/MS (m/z = 177.8, corresponding to the determination of [M+H]+ in acetonitrile).
References
[1] Patent: US2008/76813, 2008, A1. Location in patent: Page/Page column 28
2-AMINO-4-FLUOROBENZONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-AMINO-4-FLUOROBENZONITRILE manufacturers
- Product
- 2-AMINO-4-FLUOROBENZONITRILE 80517-22-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-08
- Product
- 2-Amino-4-fluorobenzonitrile 80517-22-2
- Price
- US $580.00/g
- Min. Order
- 1g
- Purity
- 98
- Supply Ability
- 500 Kg
- Release date
- 2024-02-14
- Product
- 2-AMINO-4-FLUOROBENZONITRILE 80517-22-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-03