Uses
ChemicalBook > CAS DataBase List > 2-AMINO-4-FLUOROBENZONITRILE

2-AMINO-4-FLUOROBENZONITRILE

Uses
Product Name
2-AMINO-4-FLUOROBENZONITRILE
CAS No.
80517-22-2
Chemical Name
2-AMINO-4-FLUOROBENZONITRILE
Synonyms
4-Fluoroanthranilonitrile;Amino-4-fluorobenzonitrile;2-Amino-4-fluorobenzonitrile;Benzonitrile, 2-amino-4-fluoro-;4-Fluoroanthranilonitrile, 2-Cyano-5-fluoroaniline
CBNumber
CB11263751
Molecular Formula
C7H5FN2
Formula Weight
136.13
MOL File
80517-22-2.mol
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2-AMINO-4-FLUOROBENZONITRILE Property

Melting point:
102.2 °C (decomp)
Boiling point:
284.7±25.0 °C(Predicted)
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
crystals
pka
0.80±0.10(Predicted)
color 
Light purple
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Safety

HazardClass 
TOXIC
HS Code 
2926907090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A898183
Product name
2-Amino-4-fluorobenzonitrile
Packaging
250mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA67713
Product name
2-Amino-4-fluorobenzonitrile
Packaging
25g
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA67713
Product name
2-Amino-4-fluorobenzonitrile
Packaging
50g
Price
$120
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0002679
Product name
2-AMINO-4-FLUOROBENZONITRILE
Purity
95.00%
Packaging
1G
Price
$130.2
Updated
2021/12/16
Matrix Scientific
Product number
066865
Product name
2-Amino-4-fluorobenzonitrile
Purity
98%
Packaging
25g
Price
$144
Updated
2021/12/16
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2-AMINO-4-FLUOROBENZONITRILE Chemical Properties,Usage,Production

Uses

2-Amino-4-fluorobenzonitrile is a useful research chemical for organic synthesis and other chemical processes.

Synthesis

3939-09-1

80517-22-2

53312-80-4

Using 2,4-difluorobenzonitrile (2.78 g, 20 mmol) and 3,4,5-trimethoxybenzylamine (3.94 g, 20 mmol) as raw material, the two were mixed and heated at 140 °C for 40 min. After completion of the reaction, the mixture was cooled to room temperature and subsequently dissolved in trifluoroacetic acid (TFA, 20 mL) and stirred at room temperature overnight. Afterwards, the mixture was concentrated using a rotary evaporator and subsequently partitioned between 1N NaOH solution (~100 mL, adjusted to alkaline) and ethyl acetate (100 mL). After separation of the organic layer, the aqueous layer was extracted with additional ethyl acetate (100 mL). All organic layers were combined, washed with brine (50 mL), dried over anhydrous magnesium sulfate (MgSO4) and concentrated to give an oil. Separation of the mixture by column chromatography (eluent: 10% to 40% hexane solution of ethyl acetate) gave two well separated isomeric products. Further concentration gave 4-amino-2-fluorobenzonitrile (1.07 g, 39% yield) as a white solid. The structure of the product was confirmed by LC/MS (m/z = 177.8, corresponding to the determination of [M+H]+ in acetonitrile).

References

[1] Patent: US2008/76813, 2008, A1. Location in patent: Page/Page column 28

2-AMINO-4-FLUOROBENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-4-FLUOROBENZONITRILE Suppliers

Canada 1 China 130 India 1 Italy 1 Japan 1 United Kingdom 4 United States 12 Global 150
Ricci Chimica
Tel
--
Fax
--
Email
sales@riccichimica.com
Country
Italy
ProdList
2146
Advantage
46
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View Lastest Price from 2-AMINO-4-FLUOROBENZONITRILE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-AMINO-4-FLUOROBENZONITRILE 80517-22-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-08
R&D Scientific Inc.
Product
2-Amino-4-fluorobenzonitrile 80517-22-2
Price
US $580.00/g
Min. Order
1g
Purity
98
Supply Ability
500 Kg
Release date
2024-02-14
Career Henan Chemical Co
Product
2-AMINO-4-FLUOROBENZONITRILE 80517-22-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-03

80517-22-2, 2-AMINO-4-FLUOROBENZONITRILERelated Search:

FIPRONIL-DESULFINYL AMINOACETONITRILE 2-Nitrobenzonitrile 2-Chlorobenzonitrile Benzonitrile, 2-amino-4,5-difluoro- (9CI) IFLAB-BB F2108-0005 4-FLUORO-2-ISOCYANATOBENZONITRILE 4-FLUORO-2-NITROBENZONITRILE 4-FLUORO-2-IMIDAZOL-1-YL-BENZONITRILE 2-AMINO-4-FLUOROBENZONITRILE

  • 4-Fluoroanthranilonitrile, 2-Cyano-5-fluoroaniline
  • Amino-4-fluorobenzonitrile
  • 2-Amino-4-fluorobenzonitrile
  • Benzonitrile, 2-amino-4-fluoro-
  • 4-Fluoroanthranilonitrile
  • 80517-22-2
  • Phenyls & Phenyl-Het