ChemicalBook > CAS DataBase List > Fudosteine

Fudosteine

Product Name
Fudosteine
CAS No.
13189-98-5
Chemical Name
Fudosteine
Synonyms
FUDESTEINE;FUDOSTEINE;fodosteine;Fu si temple;Fudosteine99%;Fudosteine USP/EP/BP;Fulvestrant 9 sulfone D5;Fudosteine Impurities1413;S-(3-HYDROXYPROPYL)CYSTEINE;s-(3-hydroxypropyl)-l-cystein
CBNumber
CB1128341
Molecular Formula
C6H13NO3S
Formula Weight
179.24
MOL File
13189-98-5.mol
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Fudosteine Property

Melting point:
200-202°C (dec.)
Boiling point:
354.5±42.0 °C(Predicted)
Density 
1.301±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
Water (Slightly)
form 
Solid
pka
2.09±0.10(Predicted)
color 
White to Light Brown
CAS DataBase Reference
13189-98-5(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Cayman Chemical
Product number
16722
Product name
Fudosteine
Purity
≥95%
Packaging
10mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
16722
Product name
Fudosteine
Purity
≥95%
Packaging
25mg
Price
$63
Updated
2024/03/01
Cayman Chemical
Product number
16722
Product name
Fudosteine
Purity
≥95%
Packaging
50mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
16722
Product name
Fudosteine
Purity
≥95%
Packaging
100mg
Price
$199
Updated
2024/03/01
TRC
Product number
H952575
Product name
S-(3-Hydroxypropyl)-L-cysteine
Packaging
500mg
Price
$580
Updated
2021/12/16
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Fudosteine Chemical Properties,Usage,Production

Description

Fudosteine is a cysteine derivative that interferes with the increase in goblet cell number, expression of the mucin MUC5AC, and subsequent mucin secretion, in airways agonized with tobacco smoke, isoproterenol, lipopolysaccharide, TNF-α, or oxidants. Fudosteine, which is a thiol compound with antioxidant properties, limits NF-κB signaling and reduces inflammatory gene expression. It has greater bioavailability than N-acetyl-cysteine and increases cysteine levels in cells.

Description

Fudostein was launched in Japan as a new mucoactive agent for the treatment of bronchitis and respiratory congestion. This cysteine derivative was obtained from L-cysteine by condensation with either allylic alcohol in the presence of potassium persulfate or the corresponding bromoalcohol in the presence of a base. Fudostein was shown to significantly reduce mucus glycoprotein hypersecretion and inhibit infiltration of airway mucosa by lymphocytes and inflammatory cells in bronchitic rats. When given to bronchitic rabbits, an oral dose of 500 mg/kg daily potently decreased the fucose/ N-acetylneuraminic acid in sputa, so exhibiting mucoregulatory properties. In another study with SO2-exposed rabbits, fudostein suppressed blood flow of tracheal microvasculature increased by SO2, partly due to scavenging of superoxide anion.

Chemical Properties

Off-White Powder

Originator

SS Pharmaceutical/Mitsubishi Pharma (Japan)

Uses

An antiinflammatory expectorant MUC5 mucin obstructive pulmonary disease.

Uses

An antiinflammatory expectorant used in the treatment of MUC5 mucin obstructive pulmonary disease.

Uses

Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor. MUC5AC mucin synthesis and the expression of the MUC5AC gene were increased by LPS in rats or TNF-α in NCI-H292 cells; these effects were inhibited by fudosteine treatment

Uses

A demonstrated antiinflammatory

Uses

Fudosteine is a cysteine derivative that interferes with the increase in goblet cell number, expression of the mucin MUC5AC, and subsequent mucin secretion, in airways agonized with tobacco smoke, isoproterenol, lipopolysaccharide, TNF-α, or oxidants. Fudosteine, which is a thiol compound with antioxidant properties, limits NF-κB signaling and reduces inflammatory gene expression. It has greater bioavailability than N-acetyl-cysteine and increases cysteine levels in cells.

Definition

ChEBI: Fudosteine is an organic molecular entity.

brand name

Cleanal, Spelear (Mitsubishi Pharma)

Hazard

A reproductive hazard.

Synthesis

Fudosteine is synthesized by condensation of L-cysteine with 3-bromopropyl alcohol in aqueous NaOH, or by condensation of L-cysteine with allyl alcohol by means of aqueous potassium persulfate.

Fudosteine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Fudosteine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Fudosteine 13189-98-5
Price
US $0.00/g
Min. Order
10g
Purity
99%~101%
Supply Ability
10kg/month
Release date
2021-07-28
Henan Bao Enluo International TradeCo.，LTD
Product
Fudosteine 13189-98-5
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000tons
Release date
2023-08-16
Guangzhou Biocar Biotechnology Co.,Ltd.
Product
Fudosteine 13189-98-5
Price
US $1.00/g
Min. Order
10g
Purity
99.5%
Supply Ability
1000kg
Release date
2022-01-10

13189-98-5, FudosteineRelated Search:

Tris(hydroxymethyl)aminomethane Dilauryl thiodipropionate β-Alanine ALTRENOGEST Glycine 6-Aminocaproic acid N-Aminothiourea Propionic acid Dithiooxamide S-Carboxymethyl-L-cysteine Erdosteine L-ALANINE, 3-[(3-HYDROXYPROPYL)SULFINYL]- Fudosteine Impurity 5 Fudosteine Impurity 2 Fudosteine Impurity 1 Fudosteine Impurity 3 Fudosteine Impurity 2 Fudosteine Impurity 4

  • FUDESTEINE
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  • (2R)-2-amino-3-(3-hydroxypropylsulfanyl)propanoic acid
  • (2R)-2-amino-3-(3-hydroxypropylthio)propionic acid
  • (2R)-2-azanyl-3-(3-hydroxypropylsulfanyl)propanoic acid
  • 3-[(3-Hydroxypropyl)thio]alanine
  • (r)-2-amino-3-(3-hydroxypropylthio)propionic acid
  • S-(3-HYDROXYPROPYL)CYSTEINE
  • FUDOSTEINE
  • 2-amino-3-(3-hydroxypropylthio)propanoic acid
  • 3-((3-hydroxypropyl)thio)-alanin
  • s-(3-hydroxypropyl)-l-cystein
  • s-(3-hydroxypropyl)-l-cysteine
  • Fudosteine99%
  • FUDOSTEINE(SUBJECTTOPATENTFREE)
  • (R)-2-amino-3-((3-hydroxypropyl)thio)propanoic acid
  • L-Cysteine, S-(3-hydroxypropyl)-
  • Fudosteine,S-(3-Hydroxypropyl)cysteine,3-[(3-Hydroxypropyl)thio]alanine
  • Fudosteine USP/EP/BP
  • Fudosteine Impurities1413
  • fodosteine
  • Fudosteine D6Q: What is Fudosteine D6 Q: What is the CAS Number of Fudosteine D6 Q: What is the storage condition of Fudosteine D6 Q: What are the applications of Fudosteine D6
  • FudosteineQ: What is Fudosteine Q: What is the CAS Number of Fudosteine Q: What is the storage condition of Fudosteine Q: What are the applications of Fudosteine
  • Fu si temple
  • Fulvestrant 9 sulfone D5
  • 13189-98-5
  • C6H13O2S
  • Amino Acids 13C, 2H, 15N
  • Amino Acids & Derivatives
  • Other APIs
  • Sulfur & Selenium Compounds