ChemicalBook > CAS DataBase List > 2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER

2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER

Product Name
2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
CAS No.
4815-36-5
Chemical Name
2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
Synonyms
AURORA 20210;AKOS B000514;AKOS MSC-0434;BUTTPARK 30\06-09;AKOS BBS-00002683;ART-CHEM-BB B000514;IFLAB-BB F1018-1557;CHEMBRDG-BB 3000514;TIMTEC-BB SBB006987;2-AMino-4-phenylthiophene-3-carboxylate
CBNumber
CB1129601
Molecular Formula
C13H13NO2S
Formula Weight
247.31
MOL File
4815-36-5.mol
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2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER Property

Melting point:
92-97 °C
Boiling point:
391.0±42.0 °C(Predicted)
Density 
1.231
storage temp. 
2-8°C(protect from light)
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml; Ethanol: 20 mg/ml
form 
A crystalline solid
pka
-0.14±0.10(Predicted)
CAS DataBase Reference
4815-36-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
717401
Product name
Ethyl 2-amino-4-phenylthiophene-3-carboxylate
Purity
97%
Packaging
1g
Price
$61.8
Updated
2023/01/07
Cayman Chemical
Product number
13387
Product name
ethyl-2-amino-4-phenyl Thiophene-3-Carboxylate
Purity
≥98%
Packaging
100mg
Price
$16
Updated
2024/03/01
Cayman Chemical
Product number
13387
Product name
ethyl-2-amino-4-phenyl Thiophene-3-Carboxylate
Purity
≥98%
Packaging
1g
Price
$82
Updated
2024/03/01
Cayman Chemical
Product number
13387
Product name
ethyl-2-amino-4-phenyl Thiophene-3-Carboxylate
Purity
≥98%
Packaging
250mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
13387
Product name
ethyl-2-amino-4-phenyl Thiophene-3-Carboxylate
Purity
≥98%
Packaging
500mg
Price
$56
Updated
2024/03/01
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2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Chemical Properties

Yellow solid

Uses

Ethyl 2-Amino-4-phenylthiophene-3-carboxylate is used in the design and synthesis of thieno[2,3-d]pyrimidine analogs which exhibits antiproliferative activity against human cancer cells such as liver, pancreatic and colorectal cancer.

Uses

2-Amino-4-phenyl-thiophene-3-carboxylic acid ethyl ester is a synthetic intermediate useful for pharmaceutical synthesis.

Synthesis

17277-47-3

4815-36-5

Ethyl 2-cyano-3-phenylbut-2-enoate (513.25 g, 2.3 mol) was slowly added to a vigorously stirred ethanol (500 mL) suspension of sulfur powder (76 g, 2.3 mol) at room temperature. Subsequently, diethylamine (200 mL) was added in batches over a period of 20 min, and the temperature was raised to 62 °C during the reaction. Upon completion of the reaction, the mixture was cooled to 36 °C, then heated to 50 °C and stirred continuously for 1 h at this temperature. After stopping stirring, unreacted sulfur was removed by decantation and the hot solution was cooled to room temperature. The resulting orange solid product, ethyl 2-amino-4-phenylthiophene-3-carboxylate (195 g) was collected by filtration and washed with a small amount of cold ethanol and finally dried under vacuum. The resulting product was used for subsequent experiments without further purification.

References

[1] Synthetic Communications, 2007, vol. 37, # 23, p. 4273 - 4279
[2] Patent: WO2012/131379, 2012, A1. Location in patent: Page/Page column 19
[3] Patent: US2014/206703, 2014, A1. Location in patent: Paragraph 0033; 0084; 0085

2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Sulfur Ethanol Diethylamine Acetophenone Benzene Acetic acid Ammonium acetate Ethyl cyanoacetate

Preparation Products

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2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER Suppliers

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View Lastest Price from 2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER 4815-36-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

4815-36-5, 2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTERRelated Search:

ETHYL 2-AMINO-4-(4-BROMOPHENYL)-3-THIOPHENECARBOXYLATE 2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER ETHYL 2-AMINO-4-(4-FLUOROPHENYL)THIOPHENE-3-CARBOXYLATE 2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER Ethyl thiophene-3-carboxylate 2-(2-CHLORO-ACETYLAMINO)-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER 2-(2-CHLORO-ACETYLAMINO)-4-P-TOLYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER 2-AMINO-4-(3,4-DIMETHOXY-PHENYL)-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER 3-AMINO-5-PHENYL-THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER 2-AMINO-4-(4-NITRO-PHENYL)-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER AURORA 9290 ETHYL 2-(ACETYLAMINO)-4-(4-FLUOROPHENYL)THIOPHENE-3-CARBOXYLATE AURORA 9304 2-AMINO-4-PHENYL-5-THIOCYANATO-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER BUTTPARK 91\08-88 AURORA 20604 SALOR-INT L469904-1EA ETHYL 2-AMINO-5-ETHYL-4-PHENYLTHIOPHENE-3-CARBOXYLATE

  • IFLAB-BB F1018-1557
  • ETHYL 2-AMINO-4-PHENYL-3-THIOPHENECARBOXYLATE
  • ETHYL 2-AMINO-4-PHENYLTHIOPHENE-3-CARBOXYLATE
  • CHEMBRDG-BB 3000514
  • AURORA 20210
  • BUTTPARK 30\06-09
  • ART-CHEM-BB B000514
  • 2-AMINO-4-PHENYL-3-THIOPHENECARBOXYLIC ACID, ETHYL ESTER
  • 2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
  • AKOS MSC-0434
  • AKOS BBS-00002683
  • AKOS B000514
  • 3-THIOPHENECARBOXYLIC ACID, 2-AMINO-4-PHENYL-, ETHYL ESTER
  • TIMTEC-BB SBB006987
  • 2-amino-4-phenyl-thiophene-3-carboxylicaciethylester
  • 2-AMino-4-phenylthiophene-3-carboxylate
  • amino-2ethoxycarbonyl-3phenyl-4thiophene
  • 2-Amino-4-phenyl-thiophene-3-carboxylic acid ethyl ester ,98%
  • Amino-2 ethoxycarbonyl-3 phenyl-4 thiophene [French]
  • Thiophene-3-carboxylic acid, 2-amino-4-phenyl-, ethyl ester
  • ethyl 2-amino-4-phenylthiophene-3-carboxylate(SALTDATA: FREE)
  • 2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER ISO 9001：2015 REACH
  • 2-Amino-3-(ethoxycarbonyl)-4-phenylthiophene
  • 2-Amino-4-phenylthiophen-3-carboxylic acid ethyl ester
  • ethyl 2-amino-4-phenyl-thiophene-3-carboxy
  • Ethyl 2-amino-4-phenylthiophen-3-carboxylate
  • 4815-36-5