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nimbolide

Product Name: nimbolide
CAS No.: 25990-37-8
Chemical Name: nimbolide
Synonyms: nimbolide;NSC 309909;Nimbolide (25 mg);Nimbolide, 10 mM in DMSO;Nimbolide, CyclinA and ERK1/2 inhibitor;(17R)-7α,15β:21,23-Diepoxy-6α-hydroxy-4,8-dimethyl-1-oxo-11-methoxycarbonyl-18,24-dinor-11,12-seco-5α-chola-2,13,20,22-tetrene-4α-carboxylic acid γ-lactone;methyl [(2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-furan-3-yl-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2H,5H-cyclopenta[d]naphtho[2,3-b:1,8-b''c'']difuran-6-yl]acetate;2H,5H-Cyclopenta[d']naphtho[1,8-bc:2,3-b']difuran-6-acetic acid, 8-(3-furanyl)-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2a,5a,6a,7-tetramethyl-2,5-dioxo-, methyl ester, (2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-
CBNumber: CB11328652
Molecular Formula: C27H30O7
Formula Weight: 466.52
MOL File: 25990-37-8.mol

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nimbolide Property

Melting point:: >223°C (dec.)
Boiling point:: 608.6±55.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility: Chloroform, Ethyl Acetate
form: powder
color: Light Beige to Yellow
InChIKey: KMTFKEPRKBPCJW-UHFFFAOYSA-N
SMILES: C12C3(C)C=CC(=O)C1(C)C(CC(=O)OC)C1(C)C4C(C(C=C4C)C4=COC=C4)OC1C2OC3=O

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Safety

RTECS: GY2370000
Toxicity: hamster,LD50,intraperitoneal,> 500mg/kg (500mg/kg),Toxicology Letters. Vol. 30, Pg. 159, 1986.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB00586
Product name: Nimbolide
Purity: from Azadirachta indica, ≥98%
Packaging: 5mg
Price: $354.9
Updated: 2025/07/31

Cayman Chemical

Product number: 19230
Product name: Nimbolide
Purity: ≥97%
Packaging: 5mg
Price: $251
Updated: 2024/03/01

Cayman Chemical

Product number: 19230
Product name: Nimbolide
Purity: ≥97%
Packaging: 25mg
Price: $1058
Updated: 2024/03/01

Tocris

Product number: 7289
Product name: Nimbolide
Purity: ≥97%(HPLC)
Packaging: 25
Price: $1029
Updated: 2021/12/16

Usbiological

Product number: N2567-38
Product name: Nimbolide
Packaging: 5mg
Price: $440
Updated: 2021/12/16

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nimbolide Chemical Properties,Usage,Production

Chemical Properties

Light Beige Solid

Uses

Nimbolide, a natural triterpenoid present in the edible parts of the neem tree (Azadirachta indica), was found to be growth-inhibitory in human colon carcinoma HT-29 cells. Nimbolide treatment of cells at 2.5 - 10 μM resulted in moderate to very strong growth inhibition.

Biological Activity

Nimbolide exhibits anti-malarial, anti-bacterial, and anti-cancer activities. It has been shown to induce apoptosis in osteosarcoma cells and inhibits cell migration of these cells by modulating the expression of integrin αvβ5. In human renal carcinoma cells, nimbolide induced cell cycle arrest, DNA damage, and apoptosis.It has been shown to modulate autophagy and apoptosis in pancreatic cancer.

in vivo

Nimbolide (10 mg/kg, i.v., daily, 7 days) inhibits glioblastoma multiforme tumor growth in U87EGFRvⅢ xenografted mouse model^[2].
Nimbolide (5 mg/kg, 20 mg/kg; i.p.; daily, 10 days), inhibits tumor growth in HCT-116-derived xenograft mouse, reduces the expression of proteins involved in invasion, metastasis, and angiogenesis (MMP-9, CXCR4, ICAM-1, and VEGF)^[5].

Animal Model:	HCT-116-derived xenograft mouse^[5]
Dosage:	5 mg/kg, 20 mg/kg
Administration:	Intraperitoneal injection (i.p.), daily, 10 days
Result:	Suppressed tumor growth in nude mice at a dose as low as 5 mg/kg. Reduced tumor growth by almost 90% on day 10 at a dose as low as 20 mg/kg. Didn’t affect the body weight of mice.

IC 50

NF-κB; CDK4; CDK6

storage

Store at -20°C

nimbolide Preparation Products And Raw materials

Raw materials

Preparation Products

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nimbolide Suppliers

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25990-37-8, nimbolideRelated Search:

5,7-Dihydrox -4'-methoxyisoflavone Indacaterol INDACONITINE 4-Hexanolide Toosendanin (CIS)-8-METHYLNON-6-ENOIC ACID AZELAIC ACID MONOMETHYL ESTER nimbolide 4-ACETYL-4-METHYLHEPTANEDIOIC ACID 4-HYDROXYMETHYL-4-METHYL-CYCLOHEX-2-ENONE

nimbolide

(17R)-7α,15β:21,23-Diepoxy-6α-hydroxy-4,8-dimethyl-1-oxo-11-methoxycarbonyl-18,24-dinor-11,12-seco-5α-chola-2,13,20,22-tetrene-4α-carboxylic acid γ-lactone

NSC 309909

2H,5H-Cyclopenta[d']naphtho[1,8-bc:2,3-b']difuran-6-acetic acid, 8-(3-furanyl)-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2a,5a,6a,7-tetramethyl-2,5-dioxo-, methyl ester, (2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-

methyl [(2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-furan-3-yl-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2H,5H-cyclopenta[d]naphtho[2,3-b:1,8-b''c'']difuran-6-yl]acetate

Nimbolide (25 mg)

Nimbolide, CyclinA and ERK1/2 inhibitor

Nimbolide, 10 mM in DMSO

25990-37-8

C27H30O72

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals