5-Methyl-2'-deoxycytidine
- Product Name
- 5-Methyl-2'-deoxycytidine
- CAS No.
- 838-07-3
- Chemical Name
- 5-Methyl-2'-deoxycytidine
- Synonyms
- 5-mdC;5-Me-dC;5MedCyd;5-Me-2'-dC;5-METHYL-DC;5-Methyl-2'-deoxycyt;Deoxy methylcytidine;5-Me-2'-deoxycytidine;5-methyldeoxycytidine;2'-Deoxy-5-Mecytidine
- CBNumber
- CB1132913
- Molecular Formula
- C10H15N3O4
- Formula Weight
- 241.24
- MOL File
- 838-07-3.mol
5-Methyl-2'-deoxycytidine Property
- Melting point:
- 217-219 °C(lit.)
- Boiling point:
- 492.8±55.0 °C(Predicted)
- Density
- 1?+-.0.1 g/cm3(Predicted)
- refractive index
- 44 ° (C=1.4, H2O)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly, Heated), Methanol (Slightly, Heated), Water (Slightly)
- form
- Powder
- pka
- pK1:4.33 (25°C)
- color
- White to Off-white
- Water Solubility
- Soluble in water.
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 838-07-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-24/25
- WGK Germany
- 3
- RTECS
- HA3860000
- HS Code
- 29389090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D3610
- Product name
- 2'-Deoxy-5-methylcytidine
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 100mg
- Price
- $70
- Updated
- 2024/03/01
- Product number
- D3610
- Product name
- 2'-Deoxy-5-methylcytidine
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 500mg
- Price
- $201
- Updated
- 2024/03/01
- Product number
- J65209
- Product name
- 5-Methyl-2'-deoxycytidine, 99%
- Packaging
- 1g
- Price
- $89.4
- Updated
- 2024/03/01
- Product number
- 16166
- Product name
- 5-Methyl-2'-deoxycytidine
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $84
- Updated
- 2024/03/01
- Product number
- 16166
- Product name
- 5-Methyl-2'-deoxycytidine
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $341
- Updated
- 2024/03/01
5-Methyl-2'-deoxycytidine Chemical Properties,Usage,Production
Description
5-Methyl-2'-deoxycytidine is a nucleoside analogue that inhibits the synthesis of DNA. 5-Methyl-2'-deoxycytidine prevents methylation of guanine, which disrupts the binding of guanine nucleotide-binding proteins to the dna template and prevents polymerase chain reactions. 2'-Deoxy-5-methylcytidine is also a methyltransferase inhibitor, which means it blocks the enzyme responsible for adding methyl groups to cytosine molecules.
Chemical Properties
White Solid
Uses
5-Methyl-2'-deoxycytidine is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo DNA methylation. It has been used in epigenetics research to investigate the dynamics of DNA methylation pattern in the control of gene expression.
Uses
5-Methyl-2'-deoxycytidine in single-stranded DNA can act in cis to signal de novo DNA methylation.
Uses
A Cytidine (C998300) analog and also an isostere of Thymidine (T412000).
General Description
Giel-Pietraszuk et al. developed a new method for quantification of 5-methyl-2'-deoxycytidine (m5C) in the DNA. The technique is based on the conversion of m5C into fluorescent 3, N4-etheno-5-methyl-2'-deoxycytidine (εm5C) and its identification by reversed-phase high-performance liquid chromatography (RP-HPLC)[1].The measurement of 5-meC and 5-medC in urine may help assess changes in DNA methylation status in the whole body and investigate the DNA demethylation mechanism in vivo. 5-MedC was first detected in urine using an inhibition ELISA method;12 however, because ELISA may suffer from poor selectivity and sensitivity, later urinary measurements of 5-medC were developed mainly based on the chromatographic techniques[2].
Definition
ChEBI: 5-methyl-2'-deoxycytidine is a 2'-deoxycytidine.
References
[1] Ma?gorzata Giel-Pietraszuk. “Quantification of 5-methyl-2’-deoxycytidine in the DNA.” Acta biochimica Polonica 62 2 (2015): 281–6.
[2] Chiung-Wen Hu. “Direct Analysis of 5-Methylcytosine and 5-Methyl-2′-deoxycytidine in Human Urine by Isotope Dilution LC-MS/MS: Correlations with N-Methylated Purines and Oxidized DNA Lesions.” Chemical Research in Toxicology 25 2 (2012): 462–470.
5-Methyl-2'-deoxycytidine Preparation Products And Raw materials
Raw materials
Preparation Products
5-Methyl-2'-deoxycytidine Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 5-Methyl-2'-deoxycytidine manufacturers
- Product
- 5-Methyl-2'-deoxycytidine 838-07-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-26
- Product
- 5-Methyl-2"-deoxycytidine 838-07-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 5-Methyl-2"-deoxycytidine 838-07-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10