ChemicalBook > CAS DataBase List > 5-Methyl-2'-deoxycytidine

5-Methyl-2'-deoxycytidine

Product Name
5-Methyl-2'-deoxycytidine
CAS No.
838-07-3
Chemical Name
5-Methyl-2'-deoxycytidine
Synonyms
5-mdC;5-Me-dC;5MedCyd;5-Me-2'-dC;5-METHYL-DC;5-Methyl-2'-deoxycyt;Deoxy methylcytidine;5-Me-2'-deoxycytidine;5-methyldeoxycytidine;2'-Deoxy-5-Mecytidine
CBNumber
CB1132913
Molecular Formula
C10H15N3O4
Formula Weight
241.24
MOL File
838-07-3.mol
More
Less

5-Methyl-2'-deoxycytidine Property

Melting point:
217-219 °C(lit.)
Boiling point:
492.8±55.0 °C(Predicted)
Density 
1?+-.0.1 g/cm3(Predicted)
refractive index 
44 ° (C=1.4, H2O)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly, Heated), Methanol (Slightly, Heated), Water (Slightly)
form 
Powder
pka
pK1:4.33 (25°C)
color 
White to Off-white
Water Solubility 
Soluble in water.
Stability:
Hygroscopic
CAS DataBase Reference
838-07-3(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
3
RTECS 
HA3860000
HS Code 
29389090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
D3610
Product name
2'-Deoxy-5-methylcytidine
Purity
>98.0%(HPLC)(T)
Packaging
100mg
Price
$70
Updated
2024/03/01
TCI Chemical
Product number
D3610
Product name
2'-Deoxy-5-methylcytidine
Purity
>98.0%(HPLC)(T)
Packaging
500mg
Price
$201
Updated
2024/03/01
Alfa Aesar
Product number
J65209
Product name
5-Methyl-2'-deoxycytidine, 99%
Packaging
1g
Price
$89.4
Updated
2024/03/01
Cayman Chemical
Product number
16166
Product name
5-Methyl-2'-deoxycytidine
Purity
≥98%
Packaging
1g
Price
$84
Updated
2024/03/01
Cayman Chemical
Product number
16166
Product name
5-Methyl-2'-deoxycytidine
Purity
≥98%
Packaging
5g
Price
$341
Updated
2024/03/01
More
Less

5-Methyl-2'-deoxycytidine Chemical Properties,Usage,Production

Description

5-Methyl-2'-deoxycytidine is a nucleoside analogue that inhibits the synthesis of DNA. 5-Methyl-2'-deoxycytidine prevents methylation of guanine, which disrupts the binding of guanine nucleotide-binding proteins to the dna template and prevents polymerase chain reactions. 2'-Deoxy-5-methylcytidine is also a methyltransferase inhibitor, which means it blocks the enzyme responsible for adding methyl groups to cytosine molecules.

Chemical Properties

White Solid

Uses

5-Methyl-2'-deoxycytidine is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo DNA methylation. It has been used in epigenetics research to investigate the dynamics of DNA methylation pattern in the control of gene expression.

Uses

5-Methyl-2'-deoxycytidine in single-stranded DNA can act in cis to signal de novo DNA methylation.

Uses

A Cytidine (C998300) analog and also an isostere of Thymidine (T412000).

General Description

Giel-Pietraszuk et al. developed a new method for quantification of 5-methyl-2'-deoxycytidine (m5C) in the DNA. The technique is based on the conversion of m5C into fluorescent 3, N4-etheno-5-methyl-2'-deoxycytidine (εm5C) and its identification by reversed-phase high-performance liquid chromatography (RP-HPLC)[1].The measurement of 5-meC and 5-medC in urine may help assess changes in DNA methylation status in the whole body and investigate the DNA demethylation mechanism in vivo. 5-MedC was first detected in urine using an inhibition ELISA method;12 however, because ELISA may suffer from poor selectivity and sensitivity, later urinary measurements of 5-medC were developed mainly based on the chromatographic techniques[2].

Definition

ChEBI: 5-methyl-2'-deoxycytidine is a 2'-deoxycytidine.

References

[1] Ma?gorzata Giel-Pietraszuk. “Quantification of 5-methyl-2’-deoxycytidine in the DNA.” Acta biochimica Polonica 62 2 (2015): 281–6.
[2] Chiung-Wen Hu. “Direct Analysis of 5-Methylcytosine and 5-Methyl-2′-deoxycytidine in Human Urine by Isotope Dilution LC-MS/MS: Correlations with N-Methylated Purines and Oxidized DNA Lesions.” Chemical Research in Toxicology 25 2 (2012): 462–470.

5-Methyl-2'-deoxycytidine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

5-Methyl-2'-deoxycytidine Suppliers

Americas 1 Canada 1 China 207 Europe 2 Germany 3 India 3 Japan 2 Russia 1 Slovakia 1 South Korea 1 Switzerland 1 United Kingdom 12 United States 34 Global 269
Maanshan geneyan biotech Co.,LTD
Tel
18913822354
Email
market@geneyan-bio.com
Country
China
ProdList
299
Advantage
58
Nanjing Youwei Biotechnology Co., Ltd
Tel
025-86506605 13952030024
Fax
QQ：24810051
Email
13811988123@139.com
Country
China
ProdList
24
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Hongene Biotech Corporation
Tel
021-64757213
Fax
86-21-64700613
Email
info@hongene.com
Country
China
ProdList
672
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Wuhu Huaren Science and Technology Co., Ltd.
Tel
0553-0553-0553-5842013-801-801 18155347026
Fax
086-553-5843138
Email
jinhuaren@huarensh.com
Country
China
ProdList
295
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3295
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4940
Advantage
60
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Nanjing Norris-Pharm Technology Co., Ltd
Tel
13901585132
Fax
+86-25-52131256
Email
799750417@qq.com
Country
China
ProdList
8878
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19915
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Wuhan DKY Technology Co.,Ltd.
Tel
27-81302488 18007166089
Fax
027-81302088
Email
info@dkybpc.com
Country
China
ProdList
2024
Advantage
58
TianJin Alta Scientific Co., Ltd.
Tel
022-65378550-8551
Fax
+86-022-2532-9655
Email
contact@altascientific.com
Country
China
ProdList
2773
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18042
Advantage
56
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Beijing Qinling Mountains Pharmaceutical Co., Ltd.
Tel
010-61241352 18901327973
Email
sales@qlmed.com
Country
China
ProdList
530
Advantage
58
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9648
Advantage
58
NINGBO INNO PHARMCHEM CO.,LTD.
Tel
86-574-27787657
Fax
86-574-27912196
Email
info@dearchem.com
Country
China
ProdList
4613
Advantage
58
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4943
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10276
Advantage
55
Lihe Wuhan New Chemical Materials Co., Ltd.
Tel
027-88395709
Fax
027-88391805
Country
China
ProdList
429
Advantage
50
Dongyang Honsen Co., Limited
Tel
+86-0579-86846643 18072368515
Fax
+86-0579-86846643
Email
sales@honsentech.com.cn
Country
China
ProdList
124
Advantage
55
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Alta Scientific Co., Ltd.
Tel
022-6537-8550 15522853686
Fax
022-2532-9655
Email
sales@altasci.com.cn
Country
China
ProdList
4511
Advantage
55
Wuhu Nuowei Chemical Technology Co., Ltd
Tel
0553-8233716 18055326116
Email
sales@nuowei-chem.com
Country
China
ProdList
951
Advantage
55
Zhengzhou Alfachem Co., Ltd.
Tel
0371-53765687 18937137882
Fax
QQ:2885373884
Email
2853979813@qq.com
Country
China
ProdList
7980
Advantage
55
Chengdu RunZeBenTu Chemical Co., Ltd
Tel
028-88469284 18000562381
Email
rzbtsj@163.com
Country
China
ProdList
9951
Advantage
56
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
17687
Advantage
55
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862，442785678，326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9627
Advantage
58
Henan CoreyChem Co., Ltd
Tel
0371-86658258
Fax
0371-60996044
Email
info@coreychem.com
Country
China
ProdList
10453
Advantage
58
Shanghai Xilong Biochemical Technology Co., Ltd.
Tel
021-52907766-8042
Fax
021-52906523
Country
China
ProdList
9941
Advantage
58
Lancrix Chemicals
Tel
86-21-50817262
Fax
86-21-57712035
Email
sales@lancrix.com
Country
China
ProdList
1502
Advantage
55
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20806
Advantage
60
Grader reagent
Tel
18221735425
Email
sales@xinpingchem.com
Country
China
ProdList
9942
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-0371-55629727 13323845623
Fax
037155629727
Email
2885676761@qq.com
Country
China
ProdList
10009
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
More
Less

View Lastest Price from 5-Methyl-2'-deoxycytidine manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
5-Methyl-2'-deoxycytidine 838-07-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
5-Methyl-2"-deoxycytidine 838-07-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
5-Methyl-2"-deoxycytidine 838-07-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

838-07-3, 5-Methyl-2'-deoxycytidineRelated Search:

5-METHYLCYTOSINE Thymine Methylparaben Cytarabine Cytidine Methanol Kresoxim-methyl 5-Azacytidine Basic Violet 1 Cytidine-5'-triphosphate disodium salt dihydrate Cytosine Floxuridine METSULFURON METHYL 5-Fluorocytidine Tribenuron methyl Zalcitabine Fluorocytosine Methyl salicylate

  • 5-METHYL-DC
  • 5-METHYL-2'-DEXOYCYTIDINE
  • 5-METHYL-2'-DEOXYCYTIDINE
  • 4-AMINO-1-[(2R,4S,5R)-4-HYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-5-METHYL-PYRIMIDIN-2-ONE
  • 2'-DEOXY-5-METHYLCYTIDINE
  • 2’-deoxy-5-methyl-cytidin
  • 5-Me-2'-deoxycytidine
  • 2'-Deoxy-5-methylcytidine, ≥99%(HPLC)
  • 2'-Deoxy-5-Me-Cytidine
  • 5-methyldeoxycytidine
  • 2'-Deoxy-5-methyl-D-cytidine
  • 4-amino-1-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2-one
  • 2''-DEOXY-5-METHYLCYTIDINE (5-METHYL-2''-DEOXYCYTIDINE)
  • 1-(2-Deoxy-beta-D-ribofuranosyl)-5-methylcytosine
  • 5-Methyl-2'-deoxycyt
  • 5-Me-2'-dC
  • Cytidine, 2'-deoxy-5-methyl-
  • (2R,3R,4S,5R)-2-(4-aMino-5-Methyl-1,2-dihydropyriMidin-1-yl)-5-(hydroxyMethyl)oxolane-3,4-diol
  • 4-AMino-1-(4-hydroxy-5-hydroxyMethyl-tetrahydro-furan-2-yl)-5-Methyl-1H-pyriMidin-2-one
  • 4-AMino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-MethylpyriMidin-2(1H)-one
  • 5-Me-dC
  • 5-Methyl-2'-deoxycytidine Solution, 100ppm
  • 5-Methyl-2'-deoxycytidine≥ 99% (HPLC)
  • 5-Methyl-2'-deoxycytidine, >=99%
  • Deoxy methylcytidine
  • 2'-Deoxy-5-methylcytidine&gt
  • 5MedCyd
  • 5-mdC
  • 5-Methyl-2'-deoxycytidine USP/EP/BP
  • 5-methyl-2'-deoxycytidine(5-Me-dC)
  • 5-Methyl-2'-deoxycytidine
  • 2'-Deoxy-5-methylcytidine
  • 2'-Deoxy-5-Mecytidine
  • 838-07-3
  • C10H15N3O4
  • Bases & Related Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals
  • Biochemistry
  • Nucleosides and their analogs
  • Nucleosides, Nucleotides & Related Reagents