5-Methyl-2'-deoxycytidine

Product Name: 5-Methyl-2'-deoxycytidine
CAS No.: 838-07-3
Chemical Name: 5-Methyl-2'-deoxycytidine
Synonyms: 5-mdC;5-Me-dC;5MedCyd;5-Me-2'-dC;5-METHYL-DC;5-Methyl-2'-deoxycyt;Deoxy methylcytidine;5-Me-2'-deoxycytidine;5-methyldeoxycytidine;2'-Deoxy-5-Mecytidine
CBNumber: CB1132913
Molecular Formula: C10H15N3O4
Formula Weight: 241.24
MOL File: 838-07-3.mol

More

Less

5-Methyl-2'-deoxycytidine Property

Melting point:: 217-219 °C(lit.)
Boiling point:: 492.8±55.0 °C(Predicted)
Density: 1?+-.0.1 g/cm3(Predicted)
refractive index: 44 ° (C=1.4, H2O)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly, Heated), Methanol (Slightly, Heated), Water (Slightly)
form: Powder
pka: pK1:4.33 (25°C)
color: White to Off-white
Water Solubility: Soluble in water.
Stability:: Hygroscopic
CAS DataBase Reference: 838-07-3(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-24/25
WGK Germany: 3
RTECS: HA3860000
HS Code: 29389090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: D3610
Product name: 2'-Deoxy-5-methylcytidine
Purity: >98.0%(HPLC)(T)
Packaging: 100mg
Price: $70
Updated: 2024/03/01

TCI Chemical

Product number: D3610
Product name: 2'-Deoxy-5-methylcytidine
Purity: >98.0%(HPLC)(T)
Packaging: 500mg
Price: $201
Updated: 2024/03/01

Alfa Aesar

Product number: J65209
Product name: 5-Methyl-2'-deoxycytidine, 99%
Packaging: 1g
Price: $89.4
Updated: 2024/03/01

Cayman Chemical

Product number: 16166
Product name: 5-Methyl-2'-deoxycytidine
Purity: ≥98%
Packaging: 1g
Price: $84
Updated: 2024/03/01

Cayman Chemical

Product number: 16166
Product name: 5-Methyl-2'-deoxycytidine
Purity: ≥98%
Packaging: 5g
Price: $341
Updated: 2024/03/01

More

Less

5-Methyl-2'-deoxycytidine Chemical Properties,Usage,Production

Description

5-Methyl-2'-deoxycytidine is a nucleoside analogue that inhibits the synthesis of DNA. 5-Methyl-2'-deoxycytidine prevents methylation of guanine, which disrupts the binding of guanine nucleotide-binding proteins to the dna template and prevents polymerase chain reactions. 2'-Deoxy-5-methylcytidine is also a methyltransferase inhibitor, which means it blocks the enzyme responsible for adding methyl groups to cytosine molecules.

Chemical Properties

White Solid

Uses

5-Methyl-2'-deoxycytidine is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo DNA methylation. It has been used in epigenetics research to investigate the dynamics of DNA methylation pattern in the control of gene expression.

Uses

5-Methyl-2'-deoxycytidine in single-stranded DNA can act in cis to signal de novo DNA methylation.

Uses

A Cytidine (C998300) analog and also an isostere of Thymidine (T412000).

General Description

Giel-Pietraszuk et al. developed a new method for quantification of 5-methyl-2'-deoxycytidine (m5C) in the DNA. The technique is based on the conversion of m5C into fluorescent 3, N4-etheno-5-methyl-2'-deoxycytidine (εm5C) and its identification by reversed-phase high-performance liquid chromatography (RP-HPLC)[1].The measurement of 5-meC and 5-medC in urine may help assess changes in DNA methylation status in the whole body and investigate the DNA demethylation mechanism in vivo. 5-MedC was first detected in urine using an inhibition ELISA method;12 however, because ELISA may suffer from poor selectivity and sensitivity, later urinary measurements of 5-medC were developed mainly based on the chromatographic techniques[2].

Definition

ChEBI: 5-methyl-2'-deoxycytidine is a 2'-deoxycytidine.

References

[1] Ma?gorzata Giel-Pietraszuk. “Quantification of 5-methyl-2’-deoxycytidine in the DNA.” Acta biochimica Polonica 62 2 (2015): 281–6.
[2] Chiung-Wen Hu. “Direct Analysis of 5-Methylcytosine and 5-Methyl-2′-deoxycytidine in Human Urine by Isotope Dilution LC-MS/MS: Correlations with N-Methylated Purines and Oxidized DNA Lesions.” Chemical Research in Toxicology 25 2 (2012): 462–470.

5-Methyl-2'-deoxycytidine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

5-Methyl-2'-deoxycytidine Suppliers

Americas 1 Canada 1 China 207 Europe 2 Germany 3 India 3 Japan 2 Russia 1 Slovakia 1 South Korea 1 Switzerland 1 United Kingdom 12 United States 34 Global 269

Maanshan geneyan biotech Co.,LTD

Tel: 18913822354
Email: market@geneyan-bio.com
Country: China
ProdList: 299
Advantage: 58

Nanjing Youwei Biotechnology Co., Ltd

Tel: 025-86506605 13952030024
Fax: QQ：24810051
Email: 13811988123@139.com
Country: China
ProdList: 24
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Hongene Biotech Corporation

Tel: 021-64757213
Fax: 86-21-64700613
Email: info@hongene.com
Country: China
ProdList: 672
Advantage: 61

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44689
Advantage: 61

Wuhu Huaren Science and Technology Co., Ltd.

Tel: 0553-0553-0553-5842013-801-801 18155347026
Fax: 086-553-5843138
Email: jinhuaren@huarensh.com
Country: China
ProdList: 295
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

More

Less

View Lastest Price from 5-Methyl-2'-deoxycytidine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 5-Methyl-2'-deoxycytidine 838-07-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-Methyl-2"-deoxycytidine 838-07-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-Methyl-2"-deoxycytidine 838-07-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

838-07-3, 5-Methyl-2'-deoxycytidineRelated Search:

5-METHYLCYTOSINE Thymine Methylparaben Cytarabine Cytidine Methanol Kresoxim-methyl 5-Azacytidine Basic Violet 1 Cytidine-5'-triphosphate disodium salt dihydrate Cytosine Floxuridine METSULFURON METHYL 5-Fluorocytidine Tribenuron methyl Zalcitabine Fluorocytosine Methyl salicylate

5-METHYL-DC

5-METHYL-2'-DEXOYCYTIDINE

5-METHYL-2'-DEOXYCYTIDINE

4-AMINO-1-[(2R,4S,5R)-4-HYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-5-METHYL-PYRIMIDIN-2-ONE

2'-DEOXY-5-METHYLCYTIDINE

2’-deoxy-5-methyl-cytidin

5-Me-2'-deoxycytidine

2'-Deoxy-5-methylcytidine, ≥99%(HPLC)

2'-Deoxy-5-Me-Cytidine

5-methyldeoxycytidine

2'-Deoxy-5-methyl-D-cytidine

4-amino-1-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2-one

2''-DEOXY-5-METHYLCYTIDINE (5-METHYL-2''-DEOXYCYTIDINE)

1-(2-Deoxy-beta-D-ribofuranosyl)-5-methylcytosine

5-Methyl-2'-deoxycyt

5-Me-2'-dC

Cytidine, 2'-deoxy-5-methyl-

(2R,3R,4S,5R)-2-(4-aMino-5-Methyl-1,2-dihydropyriMidin-1-yl)-5-(hydroxyMethyl)oxolane-3,4-diol

4-AMino-1-(4-hydroxy-5-hydroxyMethyl-tetrahydro-furan-2-yl)-5-Methyl-1H-pyriMidin-2-one

4-AMino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-MethylpyriMidin-2(1H)-one

5-Me-dC

5-Methyl-2'-deoxycytidine Solution, 100ppm

5-Methyl-2'-deoxycytidine≥ 99% (HPLC)

5-Methyl-2'-deoxycytidine, >=99%

Deoxy methylcytidine

2'-Deoxy-5-methylcytidine&gt

5MedCyd

5-mdC

5-Methyl-2'-deoxycytidine USP/EP/BP

5-methyl-2'-deoxycytidine(5-Me-dC)

5-Methyl-2'-deoxycytidine

2'-Deoxy-5-methylcytidine

2'-Deoxy-5-Mecytidine

838-07-3

C10H15N3O4

Bases & Related Reagents

Heterocycles

Intermediates & Fine Chemicals

Nucleotides

Pharmaceuticals

Biochemistry

Nucleosides and their analogs

Nucleosides, Nucleotides & Related Reagents