ChemicalBook > CAS DataBase List > garcinol

garcinol

Product Name: garcinol
CAS No.: 78824-30-3
Chemical Name: garcinol
Synonyms: 802;CP-54;garcinol;HSDB 7825;Camboginol;Garcinol, 10 mM in DMSO;Garcinol, HAT p300 and PCAF inhibitor;(1R,5R,7R)-3-(3,4-Dihydroxybenzyol)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]bicyclo[3.3.1]non-3-ene-2,9-dione;(1R,5R,7R)-3-(3,4-Dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-Bicyclo[3.3.1]non-3-ene-2,9-dione;Bicyclo[3.3.1]non-3-ene-2,9-dione, 3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (1R,5R,7R)-
CBNumber: CB11347121
Molecular Formula: C38H50O6
Formula Weight: 602.8
MOL File: 78824-30-3.mol

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garcinol Property

Melting point:: 132 °C
Boiling point:: 710.8±60.0 °C(Predicted)
Density: 1.114±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
form: Yellow solid.
pka: 4.50±1.00(Predicted)
color: Yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. Garcinol is prone to oxidation. Protect from exposure to air.
LogP: 11.546 (est)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P320Specific treatment is urgent (see … on this label).

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10566
Product name: Garcinol
Purity: ≥95%
Packaging: 5mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 10566
Product name: Garcinol
Purity: ≥95%
Packaging: 10mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 10566
Product name: Garcinol
Purity: ≥95%
Packaging: 25mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 10566
Product name: Garcinol
Purity: ≥95%
Packaging: 50mg
Price: $330
Updated: 2024/03/01

Usbiological

Product number: 255360
Product name: Garcinol
Packaging: 10mg
Price: $389
Updated: 2021/12/16

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garcinol Chemical Properties,Usage,Production

Description

Garcinol (78824-30-3) is a HAT (histone acetyltransferase) inhibitor (p300 IC50=7 μM and PCAF IC50=5 μM) both in vitro and in vivo.1 It potentiates TRAIL-induced apoptosis of cancer cells. In cancer cells garcinol, independent of the cell type, induces both of the TRAIL receptors, death receptor 4 (DR4) and DR5. Garcinol neither induces the receptors of normal cells nor sensitizes them to TRAIL.2

Uses

Garcinol is an inhibitor of the histone acetyltransferases (HATs) p300 and PCAF (IC50 = 7 and 5 μM, respectively). It also inhibits the HAT GCN5 in Cryptococcus neoformans, inducing temperature sensitivity and impairing growth. A polyisoprenylated benzophenone isolated from Garcinia indica, garcinol promotes neurogenesis and ex vivo expansion of human hematopoietic stem cells. Moreover, it induces apoptosis in several types of cancer cells and has anti-inflammatory actions.

Uses

Garcinol is a small molecule inhibitor of histone acetyltransferases. Used in cancer therapy. Garcinol, harvested from Garcinia indica.

Definition

ChEBI: Garcinol is a monoterpenoid.

in vivo

Garcinol (i.p.; 1 and 2 mg/kg; five times/week for 4 consecutive weeks) induces significant inhibition of tumor growth^[3].

Animal Model:	Five-week-old athymic nu/nu male mice bearing subcutaneous CAL27 tumors^[3]
Dosage:	1 and 2 mg/kg
Administration:	I.p.; five times/week for 4 consecutive weeks
Result:	Induced significant inhibition of tumor growth.

IC 50

AChE; BChE; GCN5/PCAF; Human Endogenous Metabolite

References

[1] KARANAM BALASUBRAMANYAM. Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression.[J]. The Journal of Biological Chemistry, 2004, 279 32: 33716-33726. DOI:10.1074/jbc.m402839200
[2] SAHDEO PRASAD. Garcinol potentiates TRAIL-induced apoptosis through modulation of death receptors and antiapoptotic proteins.[J]. Molecular Cancer Therapeutics, 2010, 9 4: 856-868. DOI:10.1158/1535-7163.mct-09-1113

garcinol Preparation Products And Raw materials

Raw materials

Preparation Products

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garcinol Suppliers

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View Lastest Price from garcinol manufacturers

Career Henan Chemical Co

Product: Garcinol 78824-30-3
Price: US $1.00/g
Min. Order: 1g
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-10

78824-30-3, garcinolRelated Search:

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(1R,5R,7R)-3-(3,4-Dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-Bicyclo[3.3.1]non-3-ene-2,9-dione

Camboginol

garcinol

(1R,3E,5R,7R)-3-[(3,4-dihydroxyphenyl)-hydroxy-methylidene]-8,8-dimethyl-1,7-bis(3-methylbut-2-enyl)-5-[(2S)-5-methyl-2-prop-1-en-2-yl-hex-4-enyl]bicyclo[3.3.1]nonane-2,4,9-trione

(1R,5R,7R)-3-(3,4-Dihydroxybenzyol)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]bicyclo[3.3.1]non-3-ene-2,9-dione

Bicyclo[3.3.1]non-3-ene-2,9-dione, 3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (1R,5R,7R)-

802

CP-54

HSDB 7825

Garcinol, HAT p300 and PCAF inhibitor

Garcinol, 10 mM in DMSO

78824-30-3

C38H50O6