1-Boc-(4-benzyl)piperazine

Product Name: 1-Boc-(4-benzyl)piperazine
CAS No.: 57260-70-5
Chemical Name: 1-Boc-(4-benzyl)piperazine
Synonyms: BUTTPARK 146\06-23;1-Boc-4-Benzylpiperazine;4-BENZYL-1-BOC-PIPERAZINE;1-BENZYL-4-BOC-PIPERAZINE;1-N-Boc-4-benzylpiperazine;4-BENZYL-1-T-BUTOXYCARBONYLPIPERAZINE;1-Benzyl-4-(tert-butoxycarbonyl)piperazine;TERT-BUTYL 4-BENZYL-1-PIPERAZINECARBOXYLATE;TERT-BUTYL 4-BENZYLPIPERAZINE-1-CARBOXYLATE;4-BENZYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CBNumber: CB1139932
Molecular Formula: C16H24N2O2
Formula Weight: 276.37
MOL File: 57260-70-5.mol

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1-Boc-(4-benzyl)piperazine Property

Melting point:: 71-73 °C(lit.)
Boiling point:: 362.5±35.0 °C(Predicted)
Density: 1.087±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 6.50±0.10(Predicted)
Appearance: Off-white to light yellow Solid
BRN: 797033
CAS DataBase Reference: 57260-70-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 374830
Product name: 1-Boc-(4-benzyl)piperazine
Purity: 98%
Packaging: 1g
Price: $81.22
Updated: 2025/07/31

TRC

Product number: B585330
Product name: tert-Butyl4-Benzylpiperazine-1-carboxylate
Packaging: 500mg
Price: $110
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0006571
Product name: 1-BENZYL-4-BOC-PIPERAZINE
Purity: 95.00%
Packaging: 1G
Price: $654.89
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0006571
Product name: 1-BENZYL-4-BOC-PIPERAZINE
Purity: 95.00%
Packaging: 5G
Price: $933.82
Updated: 2021/12/16

AK Scientific

Product number: 8409AB
Product name: tert-Butyl4-benzylpiperazine-1-carboxylate
Packaging: 100g
Price: $1011
Updated: 2021/12/16

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1-Boc-(4-benzyl)piperazine Chemical Properties,Usage,Production

General Description

1-Boc-(4-benzyl)piperazine is an heterocyclic building block.

Synthesis

100-39-0

57260-71-6

57260-70-5

To a stirred solution of N-BOC-piperazine (6.0 g, 33.0 mmol, 1.0 eq.) in acetonitrile (60 mL), the reaction mixture was cooled to 0°C. Subsequently, triethylamine (22 mL, 161 mmol, 5.0 eq.) and benzyl bromide (6.0 mL, 35.0 mmol, 1.1 eq.) were added slowly and dropwise. The reaction mixture was stirred continuously for about 6 hours at room temperature. After completion of the reaction, the mixture was diluted with water and extracted with dichloromethane (CH2Cl2). The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford the target product 1-benzyl-4-Boc-piperazine (6.5 g, 76.0% yield) as a white solid.

References

[1] Synthetic Communications, 2009, vol. 39, # 13, p. 2297 - 2303
[2] Patent: WO2017/17630, 2017, A1. Location in patent: Page/Page column 34-35
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 4, p. 1830 - 1842
[4] Patent: WO2017/58716, 2017, A1. Location in patent: Paragraph 00268
[5] Journal of Heterocyclic Chemistry, 2010, vol. 47, # 1, p. 54 - 62

1-Boc-(4-benzyl)piperazine Preparation Products And Raw materials

Raw materials

Benzyl chloride Ethanol Sodium sulfate Sodium thiosulfate Di-tert-butyl dicarbonate Potassium carbonate Piperazine Diethyl ether Iodine Ethyl acetate Sodium bicarbonate Dichloromethane Methanol Sodium hydroxide 1-Benzylpiperazine PETROLEUM ETHER

Preparation Products

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1-Boc-(4-benzyl)piperazine Suppliers

China 98 Germany 2 India 4 Switzerland 2 The Netherlands 1 United Kingdom 7 United States 18 Global 132

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Sense Chemicals (Shanghai) Co., Ltd.

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View Lastest Price from 1-Boc-(4-benzyl)piperazine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Boc-(4-benzyl)piperazine 57260-70-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 1-Boc-(4-benzyl)piperazine 57260-70-5
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-10

Career Henan Chemical Co

Product: 1-Boc-(4-benzyl)piperazine 57260-70-5
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-10

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57260-70-5

C16H24N2O2

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Piperaizine

API intermediates

Building Blocks

Heterocyclic Building Blocks

Piperazines