3-HYDROXY-4-BENZYLOXY BENZALDEHYDE
- Product Name
- 3-HYDROXY-4-BENZYLOXY BENZALDEHYDE
- CAS No.
- 4049-39-2
- Chemical Name
- 3-HYDROXY-4-BENZYLOXY BENZALDEHYDE
- Synonyms
- 4-BENZLOXY-3-HYDROXYBENZALDEHYDE;4-BENZLOXY-3-HYDROXYBENZALDEHYLE;4-BENZYLOXY-3-HYDROXYBENZALDEHYDE;4-HYDROXY-4-BENZYLOXYBENZALDEHYDE;3-HYDROXY-4-BENZYLOXY BENZALDEHYDE;Protocatechuic Aldehyde-4-benzyl Ether;3-Hydroxy-4-(phenylmethoxy)benzaldehyde;Benzaldehyde, 3-hydroxy-4-(phenylmethoxy)-;4-hydroxy-4-phenylmethoxy-1-cyclohexa-1,5-dienecarboxaldehyde
- CBNumber
- CB1140624
- Molecular Formula
- C14H12O3
- Formula Weight
- 228.24
- MOL File
- 4049-39-2.mol
3-HYDROXY-4-BENZYLOXY BENZALDEHYDE Property
- Melting point:
- 120 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 403.3±30.0 °C(Predicted)
- Density
- 1.238±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 8.79±0.35(Predicted)
- color
- Off-White to Light Brown
- InChI
- InChI=1S/C14H12O3/c15-9-12-6-7-14(13(16)8-12)17-10-11-4-2-1-3-5-11/h1-9,16H,10H2
- InChIKey
- HUNGEAFDVLSPAM-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC=C(OCC2=CC=CC=C2)C(O)=C1
- CAS DataBase Reference
- 4049-39-2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B286355
- Product name
- 4-Benzyloxy-3-hydroxybenzaldehyde
- Packaging
- 2.5g
- Price
- $645
- Updated
- 2021/12/16
- Product number
- 5454CC
- Product name
- 4-(Benzyloxy)-3-hydroxybenzaldehyde
- Packaging
- 5g
- Price
- $737
- Updated
- 2021/12/16
- Product number
- FB18456
- Product name
- 4-Benzyloxy-3-hydroxybenzaldehyde
- Packaging
- 5G
- Price
- $525.6
- Updated
- 2021/12/16
- Product number
- CHM0010517
- Product name
- 3-HYDROXY-4-BENZYLOXY BENZALDEHYDE
- Purity
- 95.00%
- Packaging
- 2G
- Price
- $907.5
- Updated
- 2021/12/16
- Product number
- FB18456
- Product name
- 4-Benzyloxy-3-hydroxybenzaldehyde
- Packaging
- 1g
- Price
- $155
- Updated
- 2021/12/16
3-HYDROXY-4-BENZYLOXY BENZALDEHYDE Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Solid
Uses
4-Benzyloxy-3-hydroxybenzaldehyde is useful for preparing quinazoline derivatives.
Synthesis
100-39-0
139-85-5
4049-39-2
To a solution of 3,4-dihydroxybenzaldehyde (2.03 g, 14.7 mmol) in acetone (150 mL) was added potassium carbonate (K2CO3, 3.05 g, 22.1 mmol) and benzyl bromide (1.74 mL, 14.7 mmol). The reaction mixture was stirred under reflux conditions for 4 hours. Upon completion of the reaction, the reaction mixture was filtered through Celite? 535RVS and the filtrate was subsequently concentrated under reduced pressure. The residue was purified by column chromatography using toluene/ethyl acetate (13:1, v/v) as eluent to afford 4-(benzyloxy)-3-hydroxybenzaldehyde (2.12 g, 63% yield) as colorless prismatic crystals. The product characterization data were as follows: 1H NMR (300 MHz, CDCl3) δ 5.21 (2H, s), 5.77 (1H, s), 7.05 (1H, d, J = 8.2 Hz), 7.37-7.43 (7H, m), 9.86 (1H, s); 13C NMR (75 MHz, CDCl3) δ 71.2, 111.5, 114.4, 124.4, 127.9, 128.8, 128.9, 130.8, 135.2, 146.3, 150.9, 191.0; IR (ATR) νmax 3201, 1671, 1604, 1577, 1511, 1454, 1389, 1343, 1283, 1165, 1151, 1015 , 962, 874, 811, 786, 738, 698, 678 cm-1; EIMS m/z (relative intensity) 228 [M]+ (40), 91 (100); HR-EIMS m/z: [M]+ calculated C14H12O3 228.0786, measured 228.0789; melting point 120.0-122.0°C.
References
[1] Patent: WO2014/149793, 2014, A1. Location in patent: Page/Page column 59-60; 93; 96
[2] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 22, p. 4693 - 4711
[3] Chemistry - A European Journal, 1998, vol. 4, # 1, p. 33 - 43
[4] Journal of Natural Products, 2018, vol. 81, # 2, p. 371 - 377
[5] Organic Letters, 2012, vol. 14, # 15, p. 3902 - 3905
3-HYDROXY-4-BENZYLOXY BENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
3-HYDROXY-4-BENZYLOXY BENZALDEHYDE Suppliers
- Tel
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- info@trc-canada.com
- Country
- Canada
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View Lastest Price from 3-HYDROXY-4-BENZYLOXY BENZALDEHYDE manufacturers
- Product
- 3-HYDROXY-4-BENZYLOXY BENZALDEHYDE 4049-39-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-15
- Product
- 3-HYDROXY-4-BENZYLOXY BENZALDEHYDE 4049-39-2
- Price
- US $3.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200000KG
- Release date
- 2024-07-29