ChemicalBook > CAS DataBase List > 3-HYDROXY-4-BENZYLOXY BENZALDEHYDE

3-HYDROXY-4-BENZYLOXY BENZALDEHYDE

Product Name
3-HYDROXY-4-BENZYLOXY BENZALDEHYDE
CAS No.
4049-39-2
Chemical Name
3-HYDROXY-4-BENZYLOXY BENZALDEHYDE
Synonyms
4-BENZLOXY-3-HYDROXYBENZALDEHYDE;4-BENZLOXY-3-HYDROXYBENZALDEHYLE;4-BENZYLOXY-3-HYDROXYBENZALDEHYDE;4-HYDROXY-4-BENZYLOXYBENZALDEHYDE;3-HYDROXY-4-BENZYLOXY BENZALDEHYDE;Protocatechuic Aldehyde-4-benzyl Ether;3-Hydroxy-4-(phenylmethoxy)benzaldehyde;Benzaldehyde, 3-hydroxy-4-(phenylmethoxy)-;4-hydroxy-4-phenylmethoxy-1-cyclohexa-1,5-dienecarboxaldehyde
CBNumber
CB1140624
Molecular Formula
C14H12O3
Formula Weight
228.24
MOL File
4049-39-2.mol
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3-HYDROXY-4-BENZYLOXY BENZALDEHYDE Property

Melting point:
120 °C(Solv: ethanol (64-17-5))
Boiling point:
403.3±30.0 °C(Predicted)
Density 
1.238±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
8.79±0.35(Predicted)
color 
Off-White to Light Brown
InChI
InChI=1S/C14H12O3/c15-9-12-6-7-14(13(16)8-12)17-10-11-4-2-1-3-5-11/h1-9,16H,10H2
InChIKey
HUNGEAFDVLSPAM-UHFFFAOYSA-N
SMILES
C(=O)C1=CC=C(OCC2=CC=CC=C2)C(O)=C1
CAS DataBase Reference
4049-39-2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B286355
Product name
4-Benzyloxy-3-hydroxybenzaldehyde
Packaging
2.5g
Price
$645
Updated
2021/12/16
AK Scientific
Product number
5454CC
Product name
4-(Benzyloxy)-3-hydroxybenzaldehyde
Packaging
5g
Price
$737
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB18456
Product name
4-Benzyloxy-3-hydroxybenzaldehyde
Packaging
5G
Price
$525.6
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0010517
Product name
3-HYDROXY-4-BENZYLOXY BENZALDEHYDE
Purity
95.00%
Packaging
2G
Price
$907.5
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB18456
Product name
4-Benzyloxy-3-hydroxybenzaldehyde
Packaging
1g
Price
$155
Updated
2021/12/16
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3-HYDROXY-4-BENZYLOXY BENZALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

4-Benzyloxy-3-hydroxybenzaldehyde is useful for preparing quinazoline derivatives.

Synthesis

100-39-0

139-85-5

4049-39-2

To a solution of 3,4-dihydroxybenzaldehyde (2.03 g, 14.7 mmol) in acetone (150 mL) was added potassium carbonate (K2CO3, 3.05 g, 22.1 mmol) and benzyl bromide (1.74 mL, 14.7 mmol). The reaction mixture was stirred under reflux conditions for 4 hours. Upon completion of the reaction, the reaction mixture was filtered through Celite? 535RVS and the filtrate was subsequently concentrated under reduced pressure. The residue was purified by column chromatography using toluene/ethyl acetate (13:1, v/v) as eluent to afford 4-(benzyloxy)-3-hydroxybenzaldehyde (2.12 g, 63% yield) as colorless prismatic crystals. The product characterization data were as follows: 1H NMR (300 MHz, CDCl3) δ 5.21 (2H, s), 5.77 (1H, s), 7.05 (1H, d, J = 8.2 Hz), 7.37-7.43 (7H, m), 9.86 (1H, s); 13C NMR (75 MHz, CDCl3) δ 71.2, 111.5, 114.4, 124.4, 127.9, 128.8, 128.9, 130.8, 135.2, 146.3, 150.9, 191.0; IR (ATR) νmax 3201, 1671, 1604, 1577, 1511, 1454, 1389, 1343, 1283, 1165, 1151, 1015 , 962, 874, 811, 786, 738, 698, 678 cm-1; EIMS m/z (relative intensity) 228 [M]+ (40), 91 (100); HR-EIMS m/z: [M]+ calculated C14H12O3 228.0786, measured 228.0789; melting point 120.0-122.0°C.

References

[1] Patent: WO2014/149793, 2014, A1. Location in patent: Page/Page column 59-60; 93; 96
[2] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 22, p. 4693 - 4711
[3] Chemistry - A European Journal, 1998, vol. 4, # 1, p. 33 - 43
[4] Journal of Natural Products, 2018, vol. 81, # 2, p. 371 - 377
[5] Organic Letters, 2012, vol. 14, # 15, p. 3902 - 3905

3-HYDROXY-4-BENZYLOXY BENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-HYDROXY-4-BENZYLOXY BENZALDEHYDE Suppliers

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View Lastest Price from 3-HYDROXY-4-BENZYLOXY BENZALDEHYDE manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
3-HYDROXY-4-BENZYLOXY BENZALDEHYDE 4049-39-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-15
Shaanxi Dideu Medichem Co. Ltd
Product
3-HYDROXY-4-BENZYLOXY BENZALDEHYDE 4049-39-2
Price
US $3.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2024-07-29

4049-39-2, 3-HYDROXY-4-BENZYLOXY BENZALDEHYDERelated Search:

4-BENZYLOXY-3-METHOXYACETOPHENONE 3,4-Dibenzyloxybenzaldehyde 3,5-dimethoxy-4-phenylmethoxy-benzoate FUMARPROTOCETRARIC ACID 4-BENZYLOXY-3-METHOXYBENZALDEHYDE 4-Benzyloxybenzaldehyde 4-BENZYLOXY-3-METHOXYBENZOIC ACID 4-[(4-FLUOROBENZYL)OXY]-3-METHOXYBENZENECARBALDEHYDE 3-METHOXY-4-[(4-METHOXYBENZYL)OXY]BENZENECARBALDEHYDE METHYL 7-METHOXY-2,2-DIPHENYL-1,3-BENZODIOXOLE-5-CARBOXYLATE 3-METHOXY-4-(P-NITROBENZYLOXY)BENZALDEHYDE METHYL 4-BENZYLOXY-3-METHOXYBENZOATE 4-FORMYL-2-METHOXYPHENYL BENZOATE STICTIC ACID 4-FORMYL-2-METHOXYPHENYL 3,4,5-TRIMETHOXYBENZOATE 7-HYDROXY-2,2-DIPHENYL-BENZO[1,3]DIOXOLE-5-CARBOXYLIC ACID METHYL ESTER 3,4,5-TRIBENZOYLOXYBENZOIC ACID N-PROPYL ESTER 4-(BENZYLOXY)-3,5-DIMETHOXYBENZALDEHYDE

  • 4-BENZYLOXY-3-HYDROXYBENZALDEHYDE
  • 3-HYDROXY-4-BENZYLOXY BENZALDEHYDE
  • 4-HYDROXY-4-BENZYLOXYBENZALDEHYDE
  • 4-BENZLOXY-3-HYDROXYBENZALDEHYLE
  • 4-BENZLOXY-3-HYDROXYBENZALDEHYDE
  • 3-Hydroxy-4-(phenylmethoxy)benzaldehyde
  • Protocatechuic Aldehyde-4-benzyl Ether
  • 4-hydroxy-4-phenylmethoxy-1-cyclohexa-1,5-dienecarboxaldehyde
  • Benzaldehyde, 3-hydroxy-4-(phenylmethoxy)-
  • 4049-39-2
  • Aromatics