L-AP4
- Product Name
- L-AP4
- CAS No.
- 23052-81-5
- Chemical Name
- L-AP4
- Synonyms
- GDF5;L-AP4;L-APB;SYNS2;CDMP1;GDF-5 human;GDF-5 mouse;BMP-14/ CDMP-1;BMP-14 (GDF-5/CDMP-1) human;2-ammonio-4-phosphonatobutanoate
- CBNumber
- CB1141944
- Molecular Formula
- C4H10NO5P
- Formula Weight
- 183.1
- MOL File
- 23052-81-5.mol
L-AP4 Property
- Melting point:
- 207-215 °C
- Boiling point:
- 491.7±55.0 °C(Predicted)
- Density
- 1.628±0.06 g/cm3(Predicted)
- storage temp.
- 0-6°C
- solubility
- H2O : 50 mg/mL (273.07 mM; Need ultrasonic)
- pka
- 2.19±0.10(Predicted)
- form
- solid
- color
- White
- Water Solubility
- Soluble to 5 mM in water and to 100 mM in 1eq. NaOH
- Sensitive
- Light Sensitive
- CAS DataBase Reference
- 23052-81-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A7929
- Product name
- L-(+)-2-Amino-4-phosphonobutyric acid
- Purity
- optical purity optical purity: ≥95% (HPLC, Marfey′s reagent)
- Packaging
- 0.5mg
- Price
- $103
- Updated
- 2024/03/01
- Product number
- SRP4667
- Product name
- GDF-5 human
- Purity
- recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
- Packaging
- 50μG
- Price
- $316
- Updated
- 2022/05/15
- Product number
- 165300
- Product name
- L-(+)-2-Amino-4-phosphonobutyric Acid
- Packaging
- 1mg
- Price
- $88.3
- Updated
- 2022/05/15
- Product number
- J64075
- Product name
- (S)-(+)-2-Amino-4-phosphonobutyric acid, 99%
- Packaging
- 1mg
- Price
- $93.65
- Updated
- 2024/03/01
- Product number
- J64075
- Product name
- (S)-(+)-2-Amino-4-phosphonobutyric acid, 99%
- Packaging
- 10mg
- Price
- $216.65
- Updated
- 2024/03/01
L-AP4 Chemical Properties,Usage,Production
Description
Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-
Chemical Properties
white to off-white crystalline powder
Uses
Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM). L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus.
Uses
L(+)-2-Amino-4-phosphonobutanoic acid (L-AP4) is a mGluR-4/6 receptor agonist.
Definition
ChEBI: (2S)-2-amino-4-phosphonobutanoic acid is a non-proteinogenc L-alpha-amino acid that is L-alpha-aminobutyric acid in which one of the hydrogens of the terminal methyl group has been replaced by a dihydroxy(oxido)-lambda(5)-phosphanyl group. It is a potent and selective agonist for the group III metabotropic glutamate receptors (mGluR4/6/7/8). It has a role as a metabotropic glutamate receptor agonist. It is a non-proteinogenic L-alpha-amino acid and a member of phosphonic acids.
Biological Activity
Selective group III metabotropic glutamate receptor agonist. Synaptic depressant. Agonist at the quisqualate-sensitized AP6 site in hippocampus. Also available as part of the Group III mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .
storage
Room temperature
L-AP4 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from L-AP4 manufacturers
- Product
- L-AP4 23052-81-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- L-AP4 23052-81-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95--99%
- Supply Ability
- 1ton
- Release date
- 2020-01-03