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L-AP4

Product Name
L-AP4
CAS No.
23052-81-5
Chemical Name
L-AP4
Synonyms
GDF5;L-AP4;L-APB;SYNS2;CDMP1;GDF-5 human;GDF-5 mouse;BMP-14/ CDMP-1;BMP-14 (GDF-5/CDMP-1) human;2-ammonio-4-phosphonatobutanoate
CBNumber
CB1141944
Molecular Formula
C4H10NO5P
Formula Weight
183.1
MOL File
23052-81-5.mol
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L-AP4 Property

Melting point:
207-215 °C
Boiling point:
491.7±55.0 °C(Predicted)
Density 
1.628±0.06 g/cm3(Predicted)
storage temp. 
0-6°C
solubility 
H2O : 50 mg/mL (273.07 mM; Need ultrasonic)
pka
2.19±0.10(Predicted)
form 
solid
color 
White
Water Solubility 
Soluble to 5 mM in water and to 100 mM in 1eq. NaOH
Sensitive 
Light Sensitive
CAS DataBase Reference
23052-81-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
ES7191700
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A7929
Product name
L-(+)-2-Amino-4-phosphonobutyric acid
Purity
optical purity optical purity: ≥95% (HPLC, Marfey′s reagent)
Packaging
0.5mg
Price
$103
Updated
2024/03/01
Sigma-Aldrich
Product number
SRP4667
Product name
GDF-5 human
Purity
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Packaging
50μG
Price
$316
Updated
2022/05/15
Sigma-Aldrich
Product number
165300
Product name
L-(+)-2-Amino-4-phosphonobutyric Acid
Packaging
1mg
Price
$88.3
Updated
2022/05/15
Alfa Aesar
Product number
J64075
Product name
(S)-(+)-2-Amino-4-phosphonobutyric acid, 99%
Packaging
1mg
Price
$93.65
Updated
2024/03/01
Alfa Aesar
Product number
J64075
Product name
(S)-(+)-2-Amino-4-phosphonobutyric acid, 99%
Packaging
10mg
Price
$216.65
Updated
2024/03/01
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L-AP4 Chemical Properties,Usage,Production

Description

Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM). L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus.

Chemical Properties

white to off-white crystalline powder

Uses

Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM). L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus.

Uses

L(+)-2-Amino-4-phosphonobutanoic acid (L-AP4) is a mGluR-4/6 receptor agonist.

Definition

ChEBI: (2S)-2-amino-4-phosphonobutanoic acid is a non-proteinogenc L-alpha-amino acid that is L-alpha-aminobutyric acid in which one of the hydrogens of the terminal methyl group has been replaced by a dihydroxy(oxido)-lambda(5)-phosphanyl group. It is a potent and selective agonist for the group III metabotropic glutamate receptors (mGluR4/6/7/8). It has a role as a metabotropic glutamate receptor agonist. It is a non-proteinogenic L-alpha-amino acid and a member of phosphonic acids.

Biological Activity

Selective group III metabotropic glutamate receptor agonist. Synaptic depressant. Agonist at the quisqualate-sensitized AP6 site in hippocampus. Also available as part of the Group III mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .

storage

Room temperature

L-AP4 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from L-AP4 manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
L-AP4 23052-81-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
L-AP4 23052-81-5
Price
US $1.00/KG
Min. Order
1KG
Purity
95--99%
Supply Ability
1ton
Release date
2020-01-03

23052-81-5, L-AP4Related Search:


  • L-AP4
  • L(+)-2-AMINO-4-PHOSPHONOBUTANOIC ACID
  • L-(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID
  • L-(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID (L-AP4)
  • L(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID 97%
  • (2S)-2-Amino-4-phosphonobutyric acid
  • (S)-4-Phosphono-2-aminobutanoic acid
  • (S)-4-Phosphono-2-aminobutyric acid
  • L-APB
  • L(+)-2-Amino-4-phosphonobutyric acid,97%
  • (S)-2-aMino-4-phosphonobutanoic acid
  • GDF-5 human
  • SYNS2
  • BMP-14 (GDF-5/CDMP-1) human
  • BMP-14/ CDMP-1
  • GDF-5 mouse
  • Anti-GDF5 (C-terminal) antibody produced in rabbit
  • CDMP1
  • GDF5
  • L(+)-2-Amino-4-phosphonobutanoic acid (L-AP4)
  • 2-ammonio-4-phosphonatobutanoate
  • L-(+)-2-Amino-4-phosphonobutyric Acid - CAS 23052-81-5 - Calbiochem
  • (2S)-2-amino-4-phosphonobutanoic acid
  • Butanoic acid, 2-amino-4-phosphono-, (2S)-
  • 23052-81-5
  • C4H10NO5P
  • mGluR4 and mGluR6 metabotropic glutamate receptor agonist.
  • Glutamate receptor
  • Glutamate