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3-isoquinolinecarboxaldehyde

Product Name
3-isoquinolinecarboxaldehyde
CAS No.
5470-80-4
Chemical Name
3-isoquinolinecarboxaldehyde
Synonyms
3-Formylisoquinoline;Isoquinoline-3-carbaldehyde;3-isoquinolinecarboxaldehyde;Isoquinoline-3-carboxaldehyde;Isoquinoline-3-carboxaldehyde 95%;3-Formylisoquinoline, 3-Formyl-2-azanaphthalene;3-isoquinolinecarboxaldehyde ISO 9001：2015 REACH;3-Isoquinolinecarboxaldehyde (6CI, 7CI, 8CI, 9CI, ACI)
CBNumber
CB11458256
Molecular Formula
C10H7NO
Formula Weight
157.17
MOL File
5470-80-4.mol
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3-isoquinolinecarboxaldehyde Property

Melting point:
47 °C
Boiling point:
151 °C(Press: 10 Torr)
Density 
1.223±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
pka
2.94±0.30(Predicted)
color 
White
InChI
InChI=1S/C10H7NO/c12-7-10-5-8-3-1-2-4-9(8)6-11-10/h1-7H
InChIKey
XOYMAJLARWXZBA-UHFFFAOYSA-N
SMILES
C1C2=C(C=CC=C2)C=C(C=O)N=1
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Safety

HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
I874955
Product name
Isoquinoline-3-carbaldehyde
Packaging
25mg
Price
$60
Updated
2021/12/16
TRC
Product number
I874955
Product name
Isoquinoline-3-carbaldehyde
Packaging
50mg
Price
$100
Updated
2021/12/16
Apolloscientific
Product number
OR40275
Product name
Isoquinoline-3-carboxaldehyde
Purity
95%
Packaging
250mg
Price
$93
Updated
2021/12/16
SynQuest Laboratories
Product number
4H15-1-N7
Product name
Isoquinoline-3-carboxaldehyde
Packaging
250mg
Price
$103
Updated
2021/12/16
AK Scientific
Product number
W6893
Product name
3-Isoquinolinecarboxaldehyde
Packaging
250mg
Price
$158
Updated
2021/12/16
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3-isoquinolinecarboxaldehyde Chemical Properties,Usage,Production

Synthesis Reference(s)

Journal of the American Chemical Society, 73, p. 688, 1951 DOI: 10.1021/ja01146a055

Synthesis

27104-73-0

5470-80-4

General procedure for the synthesis of isoquinoline-3-carbaldehyde from methyl isoquinoline-3-carboxylate: methyl isoquinoline-3-carboxylate (2.0 g, 10.7 mmol) was dissolved in toluene and the solution was cooled to -78 °C. Diisobutylaluminum hydride (1 M solution in toluene, 21.4 mL, 21.4 mmol) was slowly added to this solution using a syringe over a period of 15 minutes. Keeping the reaction mixture at -78 °C, the reaction was quenched with a mixture of ether (80 mL), acetic acid (20 mL) and water (8 mL). The mixture was then slowly warmed to room temperature and stirred overnight. The organic layer was separated and the solvent was evaporated. Purification by fast column chromatography (eluent gradient: 1:4 ethyl acetate/hexane to 1:3 ethyl acetate/hexane) afforded 1.1 g of the title compound isoquinoline-3-carbaldehyde in 65% yield.1H-NMR (CDCl3, 300 MHz) δ 10.24 (s, 1H), 9.35 (s, 1H), 8.36 (s, 1H), 8.07- 7.98 (m, 2H), 7.82-7.32 (m, 2H). MS: m/z 158 ([MH]+).

References

[1] Patent: WO2005/56550, 2005, A2. Location in patent: Page/Page column 75-76
[2] Patent: WO2005/92885, 2005, A1. Location in patent: Page/Page column 73
[3] Patent: WO2005/56562, 2005, A1. Location in patent: Page/Page column 71-72
[4] Tetrahedron Letters, 1999, vol. 40, # 6, p. 1211 - 1214
[5] Patent: US5554620, 1996, A

3-isoquinolinecarboxaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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3-isoquinolinecarboxaldehyde Suppliers

China 73 Germany 2 India 2 United Kingdom 1 United States 10 Global 88
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from 3-isoquinolinecarboxaldehyde manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
3-isoquinolinecarboxaldehyde 5470-80-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
3-isoquinolinecarboxaldehyde 5470-80-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
3-isoquinolinecarboxaldehyde 5470-80-4
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
500kg/month
Release date
2019-08-01

5470-80-4, 3-isoquinolinecarboxaldehydeRelated Search:

ISOQUINOLINE-3-CARBOXYLIC ACID Methyl 3-isoquinolinecarboxylate Isoquinoline-1-carboxylic acid 5-HYDROXYMETHYLISOQUINOLINE 1-ISOQUINOLINEMETHANOL 6-Isoquinolinecarboxaldehyde (9CI) ISOQUINOLINE N-OXIDE ISOQUINOLINE-1-CARBALDEHYDE 8-Isoquinolinecarbonitrile(9CI) ISOQUINOLINE-1-CARBOXYLIC ACID METHYL ESTER ETHYL ISOQUINOLINE-3-CARBOXYLATE Isoquinoline-3-carboxylic acid ISOQUINOLINE-5-CARBOXYLIC ACID 7-Isoquinolinecarboxaldehyde (6CI,9CI) p-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isoquinolyl)ethyl]benzenesulphonamide 7-isoquinolinecarboxylic acid ISOQUINOLINE-5-CARBALDEHYDE QUINOLINE-4-CARBOXYLIC ACID HYDRAZIDE

  • 3-isoquinolinecarboxaldehyde
  • Isoquinoline-3-carbaldehyde
  • 3-Formylisoquinoline
  • Isoquinoline-3-carboxaldehyde
  • 3-Formylisoquinoline, 3-Formyl-2-azanaphthalene
  • Isoquinoline-3-carboxaldehyde 95%
  • 3-isoquinolinecarboxaldehyde ISO 9001：2015 REACH
  • 3-Isoquinolinecarboxaldehyde (6CI, 7CI, 8CI, 9CI, ACI)
  • 5470-80-4
  • Building Blocks
  • Isoquinoline
  • Isoquinoline Derivertives