Isoquinoline-3-carboxylic acid

Product Name: Isoquinoline-3-carboxylic acid
CAS No.: 6624-49-3
Chemical Name: Isoquinoline-3-carboxylic acid
Synonyms: NSC 53385;AKOS BB-8838;3-ISOQUINALDIC ACID;RARECHEM AL BO 1320;3-Carboxyisoquinoline;Isoquinoline-3-carboxylicaci;ISOQUINOLINE-3-CARBOXYLIC ACID;3-ISOQUINOLINECARBOXYLIC ACID 98%;Isoquinoline-3-carboxylic acid, 98%;3-Isoquinolinecarboxylic acid (6CI,9CI)
CBNumber: CB6452027
Molecular Formula: C10H7NO2
Formula Weight: 173.17
MOL File: 6624-49-3.mol

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Isoquinoline-3-carboxylic acid Property

Melting point:: 166-167°C
Boiling point:: 366.4±17.0 °C(Predicted)
Density: 1.339±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml
form: A crystalline solid
pka: 1.20±0.30(Predicted)
color: Off-white to light yellow
InChI: InChI=1S/C10H7NO2/c12-10(13)9-5-7-3-1-2-4-8(7)6-11-9/h1-6H,(H,12,13)
InChIKey: KVMMIDQDXZOPAB-UHFFFAOYSA-N
SMILES: C1C2=C(C=CC=C2)C=C(C(O)=O)N=1
CAS DataBase Reference: 6624-49-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-36
Safety Statements: 26-37/39
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: I1246
Product name: Isoquinoline-3-carboxylic Acid
Packaging: 1G
Price: $136
Updated: 2025/07/31

TCI Chemical

Product number: I1246
Product name: Isoquinoline-3-carboxylic Acid
Packaging: 5G
Price: $408
Updated: 2025/07/31

Cayman Chemical

Product number: 19194
Product name: Isoquinoline-3-carboxylic Acid
Purity: ≥98%
Packaging: 1g
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 19194
Product name: Isoquinoline-3-carboxylic Acid
Purity: ≥98%
Packaging: 5g
Price: $356
Updated: 2024/03/01

Cayman Chemical

Product number: 19194
Product name: Isoquinoline-3-carboxylic Acid
Purity: ≥98%
Packaging: 10g
Price: $632
Updated: 2024/03/01

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Isoquinoline-3-carboxylic acid Chemical Properties,Usage,Production

Uses

Isoquinoline-3-carboxylic Acid is a reagent used in the synthesis of an anti-Trypanosoma agent, which acts as a minor groove binder affecting the biological activity.

Synthesis

74163-81-8

6624-49-3

At 0°C, 10.0 g (0.046 mmol) of (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid was dissolved in 200 ml of N,N-dimethylformamide and 5.0 g (0.032 mmol) of potassium permanganate (KMnO4) was slowly added over 30 min. The reaction mixture was stirred at room temperature for 100 h. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio CCl3:CH3OH = 5:1) to confirm complete consumption of (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid. Subsequently, the reaction mixture was concentrated under vacuum. The residue was washed several times with distilled water to give 8.1 g (83% yield) of isoquinoline-3-carboxylic acid as a yellow powder. The product was analyzed by ESI-MS (m/e) showing [M + H]+ peak of 174; 1H NMR (300 MHz, DMSO) δ/ppm = 10.81 (s, 1H), 9.52 (s, 1H), 8.43 (s, 1H), 7.52 (m, 4H); 13C NMR (75 MHz, DMSO) δ/ppm = 164.9, 152.3, 143.5, 136.2, 131.3, 129.7, 127.2, 125.8.

References

[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 5, p. 1672 - 1681
[2] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 20, p. 4434 - 4436
[3] Patent: CN106986825, 2017, A
[4] Journal of Agricultural and Food Chemistry, 2018, vol. 66, # 34, p. 8957 - 8965

Isoquinoline-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Isoquinolin-3-amine

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Isoquinoline-3-carboxylic acid Suppliers

Belgium 1 China 134 Germany 4 India 4 United Kingdom 7 United States 14 Global 164

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View Lastest Price from Isoquinoline-3-carboxylic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Isoquinoline-3-carboxylic acid 6624-49-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

Career Henan Chemical Co

Product: Isoquinoline-3-carboxylic acid 6624-49-3
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2019-12-25

6624-49-3, Isoquinoline-3-carboxylic acidRelated Search:

6-isoquinolinecarboxylic acid 7-isoquinolinecarboxylic acid 3-Isoquinolinol(9CI) 6-AMINOISOQUINOLINE C-ISOQUINOLIN-4-YL-METHYLAMINE 6-Isoquinolinyl-boronic acid Isoquinoline-4-carbaldehyde 6-Isoquinolinecarboxaldehyde (9CI) ISOQUINOLINE-3-CARBOXYLIC ACID 8-isoquinolinyl-boronic acid Isoquinoline ISOQUINOLINE-1-CARBOXYLIC ACID ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER ISOQUINOLINE-5-CARBOXYLIC ACID 7-Isoquinolinecarboxaldehyde (6CI,9CI) ISOQUINOLINE-5-CARBALDEHYDE Isoquinolin-3-ylMethanaMine hydrochloride ISOQUINOLINE-1-CARBALDEHYDE

ISOQUINOLINE-3-CARBOXYLIC ACID

RARECHEM AL BO 1320

3-ISOQUINALDIC ACID

3-ISOQUINOLINECARBOXYLIC ACID 98%

AKOS BB-8838

3-Carboxyisoquinoline

3-Isoquinolinecarboxylic acid (6CI,9CI)

NSC 53385

3-Carboxyisoquinoline, 3-Carboxy-2-azanaphthalene

Isoquinoline-3-carboxylicaci

Isoquinoline-3-carboxylic acid ISO 9001：2015 REACH

Isoquinoline-3-carboxylic acid, 98%

6624-49-3

异喹啉类化合物

carboxylic acid

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