ChemicalBook > CAS DataBase List > Isoquinoline-3-carboxylic acid

Isoquinoline-3-carboxylic acid

Product Name: Isoquinoline-3-carboxylic acid
CAS No.: 6624-49-3
Chemical Name: Isoquinoline-3-carboxylic acid
Synonyms: NSC 53385;AKOS BB-8838;3-ISOQUINALDIC ACID;RARECHEM AL BO 1320;3-Carboxyisoquinoline;Isoquinoline-3-carboxylicaci;ISOQUINOLINE-3-CARBOXYLIC ACID;3-ISOQUINOLINECARBOXYLIC ACID 98%;Isoquinoline-3-carboxylic acid, 98%;3-Isoquinolinecarboxylic acid (6CI,9CI)
CBNumber: CB6452027
Molecular Formula: C10H7NO2
Formula Weight: 173.17
MOL File: 6624-49-3.mol

Less

Isoquinoline-3-carboxylic acid Property

Melting point:: 166-167°C
Boiling point:: 366.4±17.0 °C(Predicted)
Density: 1.339±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml
form: A crystalline solid
pka: 1.20±0.30(Predicted)
color: Off-white to light yellow
InChI: InChI=1S/C10H7NO2/c12-10(13)9-5-7-3-1-2-4-8(7)6-11-9/h1-6H,(H,12,13)
InChIKey: KVMMIDQDXZOPAB-UHFFFAOYSA-N
SMILES: C1C2=C(C=CC=C2)C=C(C(O)=O)N=1
CAS DataBase Reference: 6624-49-3(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-36
Safety Statements: 26-37/39
HS Code: 2933499090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: I1246
Product name: Isoquinoline-3-carboxylic Acid
Packaging: 1G
Price: $136
Updated: 2025/07/31

TCI Chemical

Product number: I1246
Product name: Isoquinoline-3-carboxylic Acid
Packaging: 5G
Price: $408
Updated: 2025/07/31

Cayman Chemical

Product number: 19194
Product name: Isoquinoline-3-carboxylic Acid
Purity: ≥98%
Packaging: 1g
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 19194
Product name: Isoquinoline-3-carboxylic Acid
Purity: ≥98%
Packaging: 5g
Price: $356
Updated: 2024/03/01

Cayman Chemical

Product number: 19194
Product name: Isoquinoline-3-carboxylic Acid
Purity: ≥98%
Packaging: 10g
Price: $632
Updated: 2024/03/01

Less

Isoquinoline-3-carboxylic acid Chemical Properties,Usage,Production

Uses

Isoquinoline-3-carboxylic Acid is a reagent used in the synthesis of an anti-Trypanosoma agent, which acts as a minor groove binder affecting the biological activity.

Synthesis

74163-81-8

6624-49-3

At 0°C, 10.0 g (0.046 mmol) of (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid was dissolved in 200 ml of N,N-dimethylformamide and 5.0 g (0.032 mmol) of potassium permanganate (KMnO4) was slowly added over 30 min. The reaction mixture was stirred at room temperature for 100 h. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio CCl3:CH3OH = 5:1) to confirm complete consumption of (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid. Subsequently, the reaction mixture was concentrated under vacuum. The residue was washed several times with distilled water to give 8.1 g (83% yield) of isoquinoline-3-carboxylic acid as a yellow powder. The product was analyzed by ESI-MS (m/e) showing [M + H]+ peak of 174; 1H NMR (300 MHz, DMSO) δ/ppm = 10.81 (s, 1H), 9.52 (s, 1H), 8.43 (s, 1H), 7.52 (m, 4H); 13C NMR (75 MHz, DMSO) δ/ppm = 164.9, 152.3, 143.5, 136.2, 131.3, 129.7, 127.2, 125.8.

References

[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 5, p. 1672 - 1681
[2] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 20, p. 4434 - 4436
[3] Patent: CN106986825, 2017, A
[4] Journal of Agricultural and Food Chemistry, 2018, vol. 66, # 34, p. 8957 - 8965

Isoquinoline-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Isoquinolin-3-amine

Less

Isoquinoline-3-carboxylic acid Suppliers

Belgium 1 China 134 Germany 4 India 4 United Kingdom 7 United States 14 Global 164

Shanghai Targsense Scientific Co., Ltd.

Tel: 18916626092
Email: targsense@qq.com
Country: China
ProdList: 110
Advantage: 65

Beijing HengPuGao Pharmaceutical Chemistry Technology Co., Ltd.

Tel: 010-81520996 13439320863
Fax: 010-81520996
Email: hengpugao@126.com
Country: China
ProdList: 159
Advantage: 57

Wuhan EnTai Technology Development Co,.Ltd

Tel: 86-27-82330560
Fax: 86-27-82330547
Email: 2536851935@qq.com
Country: China
ProdList: 347
Advantage: 69

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

ZHIWE CHEMTECH CO LTD

Tel: 021-20221225 13917446399
Fax: QQ:115820162
Email: zwchem@163.com
Country: China
ProdList: 617
Advantage: 61

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd.

Tel: 21-54820552 18964669552
Fax: 086-21-64964478
Email: 188738128@qq.com
Country: China
ProdList: 310
Advantage: 66

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

Wuhan Haizheng Industry & Trade Development Co. Ltd

Tel: 027-8866 0053/88660577/88660578
Fax: 027-8899 1911
Country: China
ProdList: 1073
Advantage: 55

Baiyin Chengze Chemical Technology Co., Ltd.

Tel: +86 943-8535351 13389336721
Fax: +86-943-8535351
Email: sales@chengzechem.com
Country: China
ProdList: 289
Advantage: 58

Shanghai Litong Chemical Technology Co.,Ltd.

Tel: 13598610367 0373-7129549
Fax: 0373-8369699
Email: 2468833170@qq.com
Country: China
ProdList: 932
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Runpharm Technology Limited

Tel: 18171398856 2968382473
Fax: 0086-21-50758330
Email: service@runpharm.com
Country: China
ProdList: 716
Advantage: 55

shanghai cooperpharm co.,LTD .

Tel: +86-021-58975553
Fax: +86-021-58975554
Email: sales@cooperpharm.com
Country: China
ProdList: 1210
Advantage: 56

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

Chimica Laboratories Co., Ltd

Tel: 0086-573-82585213
Fax: 0086-573-82585233
Email: bai@chimicalabs.com
Country: China
ProdList: 861
Advantage: 64

Amatek Scientific Co. Ltd.

Tel: 0512-56316828 4008675858
Fax: +86-512-56316826
Email: sales@amateksci.com
Country: China
ProdList: 9874
Advantage: 55

Huainan Kedi Chemical Factory

Tel: 0554-2106669
Fax: 0554-2666215
Email: sales1@kedichem.com
Country: China
ProdList: 4924
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Wuhan Chemduro Pharm Tech Co. Ltd.

Tel: 18040571231/1402788087
Fax: sales@chemduro.com
Country: China
ProdList: 1973
Advantage: 58

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

Modachem Shanghai Co., Ltd

Tel: +86 (0)21 51320687 51371369 1744605818
Fax: +86 (0)21 51371369
Country: China
ProdList: 1578
Advantage: 58

ShangHai KenEn Chemical Technology Co., Ltd.

Tel: 13120367189
Fax: 021-50315529
Email: mychess007@163.com
Country: China
ProdList: 1994
Advantage: 55

Shanghai Balmxy Pharmaceutical Co., Ltd

Tel: 021-24206007 13764915196
Fax: 86-021-23027023
Email: sales@balmxy.com
Country: China
ProdList: 6874
Advantage: 55

Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
Fax: 021-55068248
Email: 3423497944@qq.com
Country: China
ProdList: 8144
Advantage: 55

Shanghai Tombiopharma Chemical Co. Ltd.

Tel: 13391076197
Email: tombiopharma@163.com
Country: China
ProdList: 4987
Advantage: 55

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Bellen Chemistry Co., Ltd.

Tel: 010-60400365-8001 15910885229
Fax: 010-60400361
Email: service@bellenchem.com
Country: China
ProdList: 4514
Advantage: 60

NovoChemy Ltd.

Tel: 86-(0)21-31261262 373522135
Fax: 86-(0)21-33250524
Email: sales@novochemy.com
Country: China
ProdList: 6498
Advantage: 58

Beatrice medicine technology Co., Ltd.

Tel: 15769589321 1548536191
Email: beatricechem@aliyun.com
Country: China
ProdList: 460
Advantage: 50

ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9627
Advantage: 58

Henan CoreyChem Co., Ltd

Tel: 0371-86658258
Fax: 0371-60996044
Email: info@coreychem.com
Country: China
ProdList: 10453
Advantage: 58

Grader reagent

Tel: 18221735425
Email: sales@xinpingchem.com
Country: China
ProdList: 9942
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Nanjing Klender Bio-Technology Co., Ltd.

Tel: 025-52343882 18112933882
Fax: 025-52343882
Email: sales@kldbio.com
Country: China
ProdList: 2019
Advantage: 55

Shanghai Kangman Biological Technology Co., Ltd.

Tel: 18800375331
Fax: 021-50908862
Email: kangmansales@163.com
Country: China
ProdList: 7570
Advantage: 55

Wuhan EEChem Technologies Co., Ltd

Tel: 0711-3617768 13308685235
Fax: 0711-3616558
Email: lihongcai4360@sina.com
Country: China
ProdList: 1510
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
Advantage: 58

JinJin Le Chemical Co., Ltd

Tel: 18001959627(微信同号) 18001959627
Email: jjlchem2@163.com
Country: China
ProdList: 9981
Advantage: 58

Hangzhou Molcore Biopharmatech Co.,Ltd

Tel: 400-711-5280 86-571-81025280
Fax: 86-571-85806285
Email: sales@molcore.com
Country: China
ProdList: 9967
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: (5)02557626880
Email: dt3@aikonchem.com
Country: China
ProdList: 15493
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Suzhou East Polaris Chemical Co., Ltd.

Tel: 0512-66873333 18516099287
Fax: 0512-66873333
Email: sudamaster@163.com
Country: CHINA
ProdList: 116
Advantage: 58

Less

View Lastest Price from Isoquinoline-3-carboxylic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Isoquinoline-3-carboxylic acid 6624-49-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

Career Henan Chemical Co

Product: Isoquinoline-3-carboxylic acid 6624-49-3
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2019-12-25

6624-49-3, Isoquinoline-3-carboxylic acidRelated Search:

6-isoquinolinecarboxylic acid 7-isoquinolinecarboxylic acid 3-Isoquinolinol(9CI) 6-AMINOISOQUINOLINE C-ISOQUINOLIN-4-YL-METHYLAMINE 6-Isoquinolinyl-boronic acid Isoquinoline-4-carbaldehyde 6-Isoquinolinecarboxaldehyde (9CI) ISOQUINOLINE-3-CARBOXYLIC ACID 8-isoquinolinyl-boronic acid Isoquinoline ISOQUINOLINE-1-CARBOXYLIC ACID ISOQUINOLINE-3-CARBOXYLIC ACID METHYL ESTER ISOQUINOLINE-5-CARBOXYLIC ACID 7-Isoquinolinecarboxaldehyde (6CI,9CI) ISOQUINOLINE-5-CARBALDEHYDE Isoquinolin-3-ylMethanaMine hydrochloride ISOQUINOLINE-1-CARBALDEHYDE

ISOQUINOLINE-3-CARBOXYLIC ACID

RARECHEM AL BO 1320

3-ISOQUINALDIC ACID

3-ISOQUINOLINECARBOXYLIC ACID 98%

AKOS BB-8838

3-Carboxyisoquinoline

3-Isoquinolinecarboxylic acid (6CI,9CI)

NSC 53385

3-Carboxyisoquinoline, 3-Carboxy-2-azanaphthalene

Isoquinoline-3-carboxylicaci

Isoquinoline-3-carboxylic acid ISO 9001：2015 REACH

Isoquinoline-3-carboxylic acid, 98%

6624-49-3

异喹啉类化合物

carboxylic acid

Building Blocks

Isoquinoline

Isoquinoline Derivertives