6-AMINOISOQUINOLINE
- Product Name
- 6-AMINOISOQUINOLINE
- CAS No.
- 23687-26-5
- Chemical Name
- 6-AMINOISOQUINOLINE
- Synonyms
- 6-AminoisoquinoL;Aminoisoquinoline;6-Isoquinolinamine;Isoquinolin-6-amide;6-aminoisoquanoline;6-AMINOISOQUINOLINE;Isoquinoline-6-amine;Isoquinolin-6-ylamine;6-Aminoisoquinoline 97%;6-Isoquinolinamine (9CI, ACI)
- CBNumber
- CB2244941
- Molecular Formula
- C9H8N2
- Formula Weight
- 144.17
- MOL File
- 23687-26-5.mol
6-AMINOISOQUINOLINE Property
- Melting point:
- 211-212 °C(Solv: benzene (71-43-2))
- Boiling point:
- 343.1±15.0 °C(Predicted)
- Density
- 1.210±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMF (Slightly), DMSO (Sparingly), Methanol (Slightly)
- pka
- 7.10±0.10(Predicted)
- form
- solid
- color
- Light yellow to yellow
- InChI
- InChI=1S/C9H8N2/c10-9-2-1-8-6-11-4-3-7(8)5-9/h1-6H,10H2
- InChIKey
- NGFCTYXFMDWFRQ-UHFFFAOYSA-N
- SMILES
- C1C2=C(C=C(N)C=C2)C=CN=1
N-Bromosuccinimide Price
- Product number
- A611030
- Product name
- 6-Aminoisoquinoline
- Packaging
- 10g
- Price
- $525
- Updated
- 2021/12/16
- Product number
- 036790
- Product name
- 6-Aminoisoquinoline
- Purity
- 97%
- Packaging
- 250mg
- Price
- $23
- Updated
- 2021/12/16
- Product number
- FA41825
- Product name
- 6-Aminoisoquinoline
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 069891
- Product name
- 6-Aminoisoquinoline
- Purity
- 97%
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 036790
- Product name
- 6-Aminoisoquinoline
- Purity
- 97%
- Packaging
- 1g
- Price
- $56
- Updated
- 2021/12/16
6-AMINOISOQUINOLINE Chemical Properties,Usage,Production
Description
6-Aminoisoquinoline is an organosynthetic intermediate used in the preparation of Netarsudil, which is a drug used in the treatment and management of glaucoma and high intraocular pressure.
Uses
6-Aminoisoquinoline is a reactant used in the preparation of N-[{2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)-pyridin-3-yl}methyl] N''-(6,6-fused heterocyclic) ureas as highly potent TRPV1 antagonists.
Synthesis
34784-05-9
23687-26-5
General procedure for the synthesis of 6-aminoisoquinoline from 6-bromoisoquinoline: 17.2 g of 6-bromoisoquinoline (see WO 2008/077553), 200 mL of 28% ammonia solution and 10.8 g of copper (II) sulfate pentahydrate were placed in an autoclave and sealed. The mixture was stirred and reacted at 190 °C for 6 hours. After completion of the reaction, it was cooled to room temperature and the reaction solution was poured into 250 mL of 10% aqueous sodium hydroxide solution and extracted with ethyl acetate (100 mL each time, 5 times). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated. The resulting crude product was suspended with dichloromethane and filtered to give 10.2 g of light brown crystalline 6-aminoisoquinoline in 85% yield.1H-NMR spectrum (CDCl3, δ ppm): 5.54 (broad single peak, 2H), 6.58 (single peak, 1H), 7.00 (double peak, J = 9.0 Hz, 1H), 7.35 (double peak, J = 5.5 Hz, 1H), 7.75 (double peak, J = 5.5 Hz, 1H). 7.75 (double peak, J = 9.0 Hz, 1H), 8.32 (double peak, J = 5.5 Hz, 1H), 8.98 (single peak, 1H).
References
[1] Patent: US2012/35159, 2012, A1. Location in patent: Page/Page column 8
6-AMINOISOQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-AMINOISOQUINOLINE manufacturers
- Product
- 6-AMINOISOQUINOLINE 23687-26-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-10
- Product
- 6-AMINOISOQUINOLINE 23687-26-5
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 50000tons
- Release date
- 2023-08-04
- Product
- 6-AMINOISOQUINOLINE 23687-26-5
- Price
- US $20.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 50000tons
- Release date
- 2023-08-08