Isoquinoline-5-sulphonyl chloride hydrochloride
- Product Name
- Isoquinoline-5-sulphonyl chloride hydrochloride
- CAS No.
- 105627-79-0
- Chemical Name
- Isoquinoline-5-sulphonyl chloride hydrochloride
- Synonyms
- Fasudil Impurity 30 HCl;Isoquinoline-5-Sulphonyl;isoquinolin-5-sulfonyl chloride HCl;5-Isoquinolinesulfonyl chloride HCl;Isoquinolin-5-sulphonyl chloride HCl;Isoquinoline-5-sulphonyl chloride, HCl;5-(Chlorosulphonyl)isoquinoline hydrochloride;5-Isoquinolinesulfonyl chloride, hydrochloride;ISOQUINOLINE-5-SULPHONYL CHLORIDE HYDROCHLORIDE;isoquinolin-5-ylsulphonyl chloride hydrochloride
- CBNumber
- CB1270334
- Molecular Formula
- C9H7Cl2NO2S
- Formula Weight
- 264.12
- MOL File
- 105627-79-0.mol
Isoquinoline-5-sulphonyl chloride hydrochloride Property
- Melting point:
- 173-183°C
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMSO (Sparingly, Heated)
- form
- solid
- color
- White
- Stability:
- Moisture Sensitive; Store in Freezer
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P309+P311IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- I878000
- Product name
- Isoquinoline-5-sulfonylChloride,Hydrochloride
- Packaging
- 10g
- Price
- $1295
- Updated
- 2021/12/16
- Product number
- OR9017
- Product name
- Isoquinoline-5-sulphonyl chloride hydrochloride
- Purity
- 95%
- Packaging
- 250mg
- Price
- $30
- Updated
- 2021/12/16
- Product number
- 8H62-5-V3
- Product name
- Isoquinoline-5-sulfonyl chloride hydrochloride
- Purity
- 95%
- Packaging
- 250mg
- Price
- $36
- Updated
- 2021/12/16
- Product number
- J97117
- Product name
- Isoquinoline-5-sulfonylchloridehydrochloride
- Packaging
- 1g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- OR9017
- Product name
- Isoquinoline-5-sulphonyl chloride hydrochloride
- Purity
- 95%
- Packaging
- 1g
- Price
- $87
- Updated
- 2021/12/16
Isoquinoline-5-sulphonyl chloride hydrochloride Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
Isoquinoline-5-sulfonyl Chloride, Hydrochloride (cas# 105627-79-0) is a compound useful in organic synthesis.
Synthesis
27655-40-9
105627-79-0
Anhydrous DMF (1.5 mL) was added slowly and dropwise to the suspension formed by stirring 5-isoquinolinesulfonic acid (28.3 g, 135 mmol) with thionyl chloride (150 mL, 2.06 mol) at room temperature and under nitrogen protection. The reaction mixture was heated to reflux and maintained for 2.5 hours. After completion of the reaction, it was cooled to room temperature and subsequently concentrated under reduced pressure to give a light yellow powder. The powder was suspended in anhydrous dichloromethane (200 mL), sonicated, filtered, and dried under reduced pressure at 40 °C to yield a final isoquinoline-5-sulfonyl chloride hydrochloride 29.2 g (111 mmol, 82% yield). The structure of the product was confirmed by 1H NMR (TFA-d): δ 8.48 (t, J = 7.9 Hz, 1H), 9.13-9.14 (m, 2H), 9.29 (d, J = 7.9 Hz, 1H), 9.57 (d, J = 7.0 Hz, 1H), 10.26 (s, 1H).
References
[1] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 9, p. 2317 - 2333
[2] Journal of Medicinal Chemistry, 1989, vol. 32, # 1, p. 42 - 46
[3] Journal of Medicinal Chemistry, 1989, vol. 32, # 1, p. 46 - 50
[4] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 9, p. 5277 - 5284
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 14, p. 5922 - 5933
Isoquinoline-5-sulphonyl chloride hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Isoquinoline-5-sulphonyl chloride hydrochloride Suppliers
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View Lastest Price from Isoquinoline-5-sulphonyl chloride hydrochloride manufacturers
- Product
- Isoquinoline-5-sulphonyl chloride hydrochloride 105627-79-0
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2018-12-20