ISOQUINOLINE-5-SULFONYL CHLORIDE
- Product Name
- ISOQUINOLINE-5-SULFONYL CHLORIDE
- CAS No.
- 84468-15-5
- Chemical Name
- ISOQUINOLINE-5-SULFONYL CHLORIDE
- Synonyms
- Isoquinoline Impurity 6;5-Isoquinolinesulfonyl chloride;ISOQUINOLINE-5-SULFONYL CHLORIDE;isoquinolin-5-ylsulphonyl chloride;Isoquinoline-5-sulfonylchlorideHCl;5-Isoquinolinesulfonylchloride(9CI);Isoquinoline-5-sulfonyl chloride - [K9349];ISOQUINOLINE-5-SULFONYL CHLORIDE, HYDROCHLORIDE;ISOQUINOLINE-5-SULFONYL CHLORIDE ISO 9001：2015 REACH;Isoquinoline-5-sulfonyl chloride reference substance
- CBNumber
- CB5397402
- Molecular Formula
- C9H6ClNO2S
- Formula Weight
- 227.67
- MOL File
- 84468-15-5.mol
ISOQUINOLINE-5-SULFONYL CHLORIDE Property
- Melting point:
- 173-183°C
- Boiling point:
- 371.2±17.0 °C(Predicted)
- Density
- 1.483
- Flash point:
- 178.3℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Sparingly, Heated)
- form
- Solid
- pka
- 3.09±0.13(Predicted)
- color
- White to Off-White
- Stability:
- Moisture Sensitive
- CAS DataBase Reference
- 84468-15-5(CAS DataBase Reference)
Safety
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36/37
- HS Code
- 29334900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
N-Bromosuccinimide Price
- Product number
- 280561
- Product name
- Isoquinoline-5-sulfonyl chloride, hydrochloride
- Packaging
- 500mg
- Price
- $418
- Updated
- 2021/12/16
- Product number
- I918605
- Product name
- Isoquinoline-5-sulfonylChloride
- Packaging
- 50mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 11237
- Product name
- Isoquinoline-5-sulfonylChlorideHCl
- Packaging
- 1g
- Price
- $875
- Updated
- 2021/12/16
- Product number
- 11237
- Product name
- Isoquinoline-5-sulfonylChlorideHCl
- Packaging
- 5G
- Price
- $2000
- Updated
- 2021/12/16
- Product number
- Y5567
- Product name
- Isoquinoline-5-sulfonylchloride
- Packaging
- 5g
- Price
- $2061
- Updated
- 2021/12/16
ISOQUINOLINE-5-SULFONYL CHLORIDE Chemical Properties,Usage,Production
Chemical Properties
Colourless Crystalline Solid
Synthesis
27655-40-9
84468-15-5
The general procedure for the synthesis of isoquinoline-5-sulfonyl chloride from 5-isoquinolinesulfonic acid was as follows: 5-isoquinolinesulfonic acid was placed in a round-bottomed flask, 6 mL of thionyl chloride and 1 drop of N,N-dimethylformamide (DMF) were added, and the reaction was carried out at reflux for 3 hours. Upon completion of the reaction, the excess thionyl chloride was removed using a rotary evaporator. Dichloromethane (DCM) was added to the residual solid and the solid product was collected by filtration. The solid was washed three times with DCM and subsequently dried in a vacuum oven to give a white solid intermediate 2 (1 g, 91.9% yield). Intermediate 2 (130.00 mg, 571.01 μmol) was slowly added to a solution of DCM (6 mL) containing ethylenediamine (381.30 μL, 5.71 mmol) under ice-bath conditions. After removing the ice bath, the mixture was allowed to react for 3 h at room temperature. Upon completion of the reaction, the mixture was washed with water to remove the remaining ethylenediamine. The organic phase was removed using a rotary evaporator and the residue was recrystallized by ether to give brown solid 3 (91.8 mg, 60% yield).
References
[1] Patent: US2017/37050, 2017, A1. Location in patent: Paragraph 0064; 0068; 0069
[2] Patent: CN106279136, 2017, A. Location in patent: Paragraph 0022
[3] Patent: US5891909, 1999, A
[4] Patent: US6235778, 2001, B1
[5] Patent: EP906091, 2006, B1. Location in patent: Page/Page column 48
ISOQUINOLINE-5-SULFONYL CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ISOQUINOLINE-5-SULFONYL CHLORIDE manufacturers
- Product
- Isoquinoline-5-sulfonyl chloride 84468-15-5
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 600 tons
- Release date
- 2020-01-02
- Product
- ISOQUINOLINE-5-SULFONYL CHLORIDE 84468-15-5
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2018-12-20