ChemicalBook > CAS DataBase List > ISOQUINOLINE-5-SULFONYL CHLORIDE

ISOQUINOLINE-5-SULFONYL CHLORIDE

Product Name: ISOQUINOLINE-5-SULFONYL CHLORIDE
CAS No.: 84468-15-5
Chemical Name: ISOQUINOLINE-5-SULFONYL CHLORIDE
Synonyms: Isoquinoline Impurity 6;5-Isoquinolinesulfonyl chloride;ISOQUINOLINE-5-SULFONYL CHLORIDE;isoquinolin-5-ylsulphonyl chloride;Isoquinoline-5-sulfonylchlorideHCl;5-Isoquinolinesulfonylchloride(9CI);Isoquinoline-5-sulfonyl chloride - [K9349];ISOQUINOLINE-5-SULFONYL CHLORIDE, HYDROCHLORIDE;ISOQUINOLINE-5-SULFONYL CHLORIDE ISO 9001：2015 REACH;Isoquinoline-5-sulfonyl chloride reference substance
CBNumber: CB5397402
Molecular Formula: C9H6ClNO2S
Formula Weight: 227.67
MOL File: 84468-15-5.mol

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ISOQUINOLINE-5-SULFONYL CHLORIDE Property

Melting point:: 173-183°C
Boiling point:: 371.2±17.0 °C(Predicted)
Density: 1.483
Flash point:: 178.3℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Sparingly, Heated)
form: Solid
pka: 3.09±0.13(Predicted)
color: White to Off-White
Stability:: Moisture Sensitive
CAS DataBase Reference: 84468-15-5(CAS DataBase Reference)

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Safety

Risk Statements: 22-36/37/38
Safety Statements: 26-36/37
HS Code: 29334900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

TRC

Product number: I918605
Product name: Isoquinoline-5-sulfonylChloride
Packaging: 50mg
Price: $200
Updated: 2021/12/16

Usbiological

Product number: 280561
Product name: Isoquinoline-5-sulfonyl chloride, hydrochloride
Packaging: 500mg
Price: $418
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 11237
Product name: Isoquinoline-5-sulfonylChlorideHCl
Packaging: 1g
Price: $875
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 11237
Product name: Isoquinoline-5-sulfonylChlorideHCl
Packaging: 5G
Price: $2000
Updated: 2021/12/16

AK Scientific

Product number: Y5567
Product name: Isoquinoline-5-sulfonylchloride
Packaging: 5g
Price: $2061
Updated: 2021/12/16

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ISOQUINOLINE-5-SULFONYL CHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Colourless Crystalline Solid

Synthesis

27655-40-9

84468-15-5

The general procedure for the synthesis of isoquinoline-5-sulfonyl chloride from 5-isoquinolinesulfonic acid was as follows: 5-isoquinolinesulfonic acid was placed in a round-bottomed flask, 6 mL of thionyl chloride and 1 drop of N,N-dimethylformamide (DMF) were added, and the reaction was carried out at reflux for 3 hours. Upon completion of the reaction, the excess thionyl chloride was removed using a rotary evaporator. Dichloromethane (DCM) was added to the residual solid and the solid product was collected by filtration. The solid was washed three times with DCM and subsequently dried in a vacuum oven to give a white solid intermediate 2 (1 g, 91.9% yield). Intermediate 2 (130.00 mg, 571.01 μmol) was slowly added to a solution of DCM (6 mL) containing ethylenediamine (381.30 μL, 5.71 mmol) under ice-bath conditions. After removing the ice bath, the mixture was allowed to react for 3 h at room temperature. Upon completion of the reaction, the mixture was washed with water to remove the remaining ethylenediamine. The organic phase was removed using a rotary evaporator and the residue was recrystallized by ether to give brown solid 3 (91.8 mg, 60% yield).

References

[1] Patent: US2017/37050, 2017, A1. Location in patent: Paragraph 0064; 0068; 0069
[2] Patent: CN106279136, 2017, A. Location in patent: Paragraph 0022
[3] Patent: US5891909, 1999, A
[4] Patent: US6235778, 2001, B1
[5] Patent: EP906091, 2006, B1. Location in patent: Page/Page column 48

ISOQUINOLINE-5-SULFONYL CHLORIDE Preparation Products And Raw materials

Raw materials

FUMING SULFURIC ACID Isoquinoline N,N-Dimethylformamide Dichloromethane Thionyl chloride Sulfuric acid

Preparation Products

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View Lastest Price from ISOQUINOLINE-5-SULFONYL CHLORIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Isoquinoline-5-sulfonyl chloride 84468-15-5
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 600 tons
Release date: 2020-01-02

Career Henan Chemical Co

Product: ISOQUINOLINE-5-SULFONYL CHLORIDE 84468-15-5
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-20

84468-15-5, ISOQUINOLINE-5-SULFONYL CHLORIDERelated Search:

Isoquinoline-5-sulphonyl chloride hydrochloride p-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isoquinolyl)ethyl]benzenesulphonamide Tosyl chloride Sulfuryl chloride ISOQUINOLINE-8-CARBOXYLIC ACID 7-isoquinolinecarboxylic acid 1-ISOQUINOLINEMETHANOL ISOQUINOLINE-1-CARBALDEHYDE ISOQUINOLINE-1-CARBOXYLIC ACID METHYL ESTER Isoquinoline-3-carboxylic acid ISOQUINOLIN-3-AMINE Isoquinoline-3-carboxiMidaMide hydrochloride ISOQUINOLINE-4-BORONIC ACID HYDROCHLORIDE 8-isoquinolinyl-boronic acid Isoquinoline-7-carboxaMide C-ISOQUINOLIN-4-YL-METHYLAMINE ISOQUINOLINE-5-CARBOXYLIC ACID Methyl 3-isoquinolinecarboxylate

ISOQUINOLINE-5-SULFONYL CHLORIDE

ISOQUINOLINE-5-SULFONYL CHLORIDE, HYDROCHLORIDE

5-Isoquinolinesulfonyl chloride

5-Isoquinolinesulfonylchloride(9CI)

Isoquinoline-5-sulfonylchlorideHCl

isoquinolin-5-ylsulphonyl chloride

Isoquinoline Impurity 6

Isoquinoline-5-sulfonyl chloride reference substance

ISOQUINOLINE-5-SULFONYL CHLORIDE ISO 9001：2015 REACH

Isoquinoline-5-sulfonyl chloride - [K9349]

84468-15-5

Aromatics Compounds

Aromatics

Sulfonyl Chlorides

Sulfur & Selenium Compounds

SULFONYLHALIDE