8-isoquinolinyl-boronic acid

Product Name: 8-isoquinolinyl-boronic acid
CAS No.: 721401-43-0
Chemical Name: 8-isoquinolinyl-boronic acid
Synonyms: 8-Boronoisoquinoline;8-ISOQUINOLYLBORONIC ACID;isoquinolin-8-ylboronicaci;Isoquinoline-8-boronic acid;Isoquinonline-8-boronic acid;Isoquinoliine-8-boronic acid;Isoquinolin-8-ylboronic acid;8-isoquinolinyl-boronic acid;isoquinolin-8-yl-8-boronic acid;Boronic acid, B-8-isoquinolinyl-
CBNumber: CB71562102
Molecular Formula: C9H8BNO2
Formula Weight: 172.98
MOL File: 721401-43-0.mol

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8-isoquinolinyl-boronic acid Property

Boiling point:: 419.1±37.0 °C(Predicted)
Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 7.46±0.30(Predicted)
form: powder
color: Yellow

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Safety

HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: I917975
Product name: 8-Isoquinolineboronicacid
Packaging: 25mg
Price: $45
Updated: 2021/12/16

Usbiological

Product number: 280908
Product name: Isoquinonline-8-boronic acid
Packaging: 100mg
Price: $379
Updated: 2021/12/16

ChemScene

Product number: CS-B1264
Product name: 8-Isoquinolinylboronicacid
Purity: 99.94%
Packaging: 5g
Price: $441
Updated: 2021/12/16

Apolloscientific

Product number: OR60072
Product name: Isoquinoline-8-boronicacid
Packaging: 1g
Price: $261
Updated: 2021/12/16

Matrix Scientific

Product number: 188424
Product name: Isoquinolin-8-yl-8-boronic acid
Packaging: 1g
Price: $281
Updated: 2021/12/16

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8-isoquinolinyl-boronic acid Chemical Properties,Usage,Production

Chemical Properties

Yellow to beige solid

Synthesis

63927-22-0

121-43-7

721401-43-0

To a solution of 8-bromoisoquinoline (2.0 g, 9.6 mmol) in tetrahydrofuran (THF, 40 mL) was slowly added n-butyllithium (n-BuLi, 2.5 M, 4.2 mL, 10.6 mmol) dropwise at -78 °C and under nitrogen protection. After 1 hour of reaction, trimethyl borate (B(OMe)3, 2.0 g, 19.2 mmol) was added, followed by slow warming of the reaction mixture to 0 °C and kept for 1 hour. Upon completion of the reaction, the reaction was quenched with saturated aqueous sodium bicarbonate (NaHCO3) followed by three extractions with ethyl acetate (EtOAc). The organic layers were combined, washed with saturated saline, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to afford the target product 8-isoquinolineboronic acid (680 mg, 41% yield) as a light yellow solid. Liquid chromatography-mass spectrometry (LCMS) analysis showed [M+H]+ m/z 174.1.

References

[1] Patent: WO2018/165718, 2018, A1. Location in patent: Page/Page column 93

8-isoquinolinyl-boronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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8-isoquinolinyl-boronic acid Suppliers

China 69 Germany 1 India 1 United Kingdom 1 United States 9 Global 81

J & K SCIENTIFIC LTD.

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View Lastest Price from 8-isoquinolinyl-boronic acid manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 8-isoquinolinyl-boronic acid 721401-43-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 8-isoquinolinyl-boronic acid 721401-43-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: 8-isoquinolinyl-boronic acid 721401-43-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kgs
Release date: 2020-02-17

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8-isoquinolinyl-boronic acid

Isoquinolin-8-ylboronic acid

Isoquinoline-8-boronic acid

Isoquinoliine-8-boronic acid

isoquinolin-8-yl-8-boronic acid

8-Boronoisoquinoline

Isoquinonline-8-boronic acid

BORONIC ACID,8-ISOQUINOLINYL- (9CI)

8-ISOQUINOLYLBORONIC ACID

Isoquinonline-8-boronic acid≥ 95% (HPLC)

Boronic acid, B-8-isoquinolinyl-

isoquinolin-8-ylboronicaci

721401-43-0

Isoquinoline

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