ChemicalBook > CAS DataBase List > 6-AMINOISOQUINOLINE

6-AMINOISOQUINOLINE

Product Name: 6-AMINOISOQUINOLINE
CAS No.: 23687-26-5
Chemical Name: 6-AMINOISOQUINOLINE
Synonyms: 6-AminoisoquinoL;Aminoisoquinoline;6-Isoquinolinamine;Isoquinolin-6-amide;6-aminoisoquanoline;6-AMINOISOQUINOLINE;Isoquinoline-6-amine;Isoquinolin-6-ylamine;6-Aminoisoquinoline 97%;6-Isoquinolinamine (9CI, ACI)
CBNumber: CB2244941
Molecular Formula: C9H8N2
Formula Weight: 144.17
MOL File: 23687-26-5.mol

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6-AMINOISOQUINOLINE Property

Melting point:: 211-212 °C(Solv: benzene (71-43-2))
Boiling point:: 343.1±15.0 °C(Predicted)
Density: 1.210±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMF (Slightly), DMSO (Sparingly), Methanol (Slightly)
pka: 7.10±0.10(Predicted)
form: solid
color: Light yellow to yellow
InChI: InChI=1S/C9H8N2/c10-9-2-1-8-6-11-4-3-7(8)5-9/h1-6H,10H2
InChIKey: NGFCTYXFMDWFRQ-UHFFFAOYSA-N
SMILES: C1C2=C(C=C(N)C=C2)C=CN=1

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Safety

Hazard Codes: Xn
Risk Statements: 22-36
Safety Statements: 26
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

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N-Bromosuccinimide Price

TRC

Product number: A611030
Product name: 6-Aminoisoquinoline
Packaging: 10g
Price: $525
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-1-06
Product name: 6-Aminoisoquinoline
Packaging: 1g
Price: $255
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA41825
Product name: 6-Aminoisoquinoline
Packaging: 10g
Price: $270
Updated: 2021/12/16

Apolloscientific

Product number: OR60070
Product name: 6-Aminoisoquinoline
Purity: 97%
Packaging: 10g
Price: $319
Updated: 2021/12/16

AK Scientific

Product number: V1648
Product name: 6-Aminoisoquinoline
Packaging: 10g
Price: $340
Updated: 2021/12/16

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6-AMINOISOQUINOLINE Chemical Properties,Usage,Production

Description

6-Aminoisoquinoline is an organosynthetic intermediate used in the preparation of Netarsudil, which is a drug used in the treatment and management of glaucoma and high intraocular pressure.

Uses

6-Aminoisoquinoline is a reactant used in the preparation of N-[{2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)-pyridin-3-yl}methyl] N''-(6,6-fused heterocyclic) ureas as highly potent TRPV1 antagonists.

Synthesis

34784-05-9

23687-26-5

General procedure for the synthesis of 6-aminoisoquinoline from 6-bromoisoquinoline: 17.2 g of 6-bromoisoquinoline (see WO 2008/077553), 200 mL of 28% ammonia solution and 10.8 g of copper (II) sulfate pentahydrate were placed in an autoclave and sealed. The mixture was stirred and reacted at 190 °C for 6 hours. After completion of the reaction, it was cooled to room temperature and the reaction solution was poured into 250 mL of 10% aqueous sodium hydroxide solution and extracted with ethyl acetate (100 mL each time, 5 times). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated. The resulting crude product was suspended with dichloromethane and filtered to give 10.2 g of light brown crystalline 6-aminoisoquinoline in 85% yield.1H-NMR spectrum (CDCl3, δ ppm): 5.54 (broad single peak, 2H), 6.58 (single peak, 1H), 7.00 (double peak, J = 9.0 Hz, 1H), 7.35 (double peak, J = 5.5 Hz, 1H), 7.75 (double peak, J = 5.5 Hz, 1H). 7.75 (double peak, J = 9.0 Hz, 1H), 8.32 (double peak, J = 5.5 Hz, 1H), 8.98 (single peak, 1H).

References

[1] Patent: US2012/35159, 2012, A1. Location in patent: Page/Page column 8

6-AMINOISOQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-AMINOISOQUINOLINE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 6-AMINOISOQUINOLINE 23687-26-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-10

Henan Bao Enluo International TradeCo.，LTD

Product: 6-AMINOISOQUINOLINE 23687-26-5
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 50000tons
Release date: 2023-08-04

Henan Bao Enluo International TradeCo.，LTD

Product: 6-AMINOISOQUINOLINE 23687-26-5
Price: US $20.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 50000tons
Release date: 2023-08-08

23687-26-5, 6-AMINOISOQUINOLINERelated Search:

6-isoquinolinecarboxylic acid Isoquinoline-5-boronic acid Isoquinolin-3-ylMethanaMine hydrochloride 3-isoquinolinecarboxaldehyde Isoquinoline-5-sulphonyl chloride hydrochloride 8-Isoquinolinecarbonitrile(9CI) ISOQUINOLINE-1-CARBOXYLIC ACID METHYL ESTER Isoquinoline-4-carboxylic acid isoquinolin-3-ylmethanol ISOQUINOLINE-8-CARBALDEHYDE 7-isoquinolinecarboxylic acid ISOQUINOLINE-5-CARBALDEHYDE Isoquinoline-3-carboxylic acid 8-AMINOISOQUINOLINE,8-Aminoisoquinoline95%,8-Aminoisoquinoline 98% 5-Aminoisoquinoline ,99%,5-AMINOISOQUINOLINE 4-AMINOISOQUINOLINE 3-AMINOISOQUINOLINE 1-AMINOISOQUINOLINE

6-AMINOISOQUINOLINE

6-aminoisoquanoline

6-Isoquinolinamine

Isoquinoline-6-amine

Isoquinolin-6-ylamine

Isoquinolin-6-amine, 6-Amino-2-azanaphthalene

Isoquinoline,6-amino- (7CI,8CI)

Aminoisoquinoline

Isoquinolin-6-amide

6-Aminoisoquinoline 97%

6-AminoisoquinoL

6-AMINOISOQUINOLINE ISO 9001：2015 REACH

6-Isoquinolinamine (9CI, ACI)

23687-26-5

23678-26-5

Building Blocks

Isoquinoline