Isoquinoline-4-carboxylic acid
- Product Name
- Isoquinoline-4-carboxylic acid
- CAS No.
- 7159-36-6
- Chemical Name
- Isoquinoline-4-carboxylic acid
- Synonyms
- 4-Carboxyisoquinoline;Isoquinoline-4-carboxylicaci;4-Isoquinolinecarboxylic acid;ISOQUINOLINE-4-CARBOXYLIC ACID;Isoquinoline-4-carboxylic acid ISO 9001：2015 REACH;4-Isoquinolinecarboxylic acid (6CI, 7CI, 8CI, 9CI, ACI)
- CBNumber
- CB5377709
- Molecular Formula
- C10H7NO2
- Formula Weight
- 173.17
- MOL File
- 7159-36-6.mol
Isoquinoline-4-carboxylic acid Property
- Melting point:
- 264-266 °C
- Boiling point:
- 405.6±18.0 °C(Predicted)
- Density
- 1.339±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 1.00±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- I918003
- Product name
- Isoquinoline-4-carboxylicacid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- I918003
- Product name
- Isoquinoline-4-carboxylicacid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 452728
- Product name
- Isoquinoline-4-carboxylic acid
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 4H21-1-XF
- Product name
- Isoquinoline-4-carboxylic acid
- Packaging
- 5G
- Price
- $396
- Updated
- 2021/12/16
- Product number
- CAPOI11323
- Product name
- Isoquinoline-4-carboxylicacid
- Purity
- 95%
- Packaging
- 5g
- Price
- $575
- Updated
- 2021/12/16
Isoquinoline-4-carboxylic acid Chemical Properties,Usage,Production
Synthesis
34846-65-6
7159-36-6
The general procedure for the synthesis of 4-isoquinolinecarboxylic acid from 4-cyanoisoquinoline was as follows: potassium hydroxide (20 g, dissolved in 20 mL of water) was added to a stirred solution of 4-cyanoisoquinoline (3.0 g, 19.45 mmol) in ethanol (30 mL) and the reaction mixture was refluxed overnight. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure to remove the ethanol. Subsequently, the residue was washed with water and the aqueous layer was extracted with ether (Et2O). The aqueous layer was neutralized with 1N hydrochloric acid and extracted with ethyl acetate (EtOAc). The organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered, and concentrated under reduced pressure to give 4-isoquinolinecarboxylic acid (2 g, 59.3% yield) as an off-white solid.
References
[1] Patent: US2013/178457, 2013, A1. Location in patent: Paragraph 0221
[2] Patent: WO2013/5168, 2013, A2. Location in patent: Page/Page column 40
[3] Journal of the American Chemical Society, 1940, vol. 62, p. 3030
[4] Journal of the American Chemical Society, 1939, vol. 61, p. 183
[5] Archiv der Pharmazie, 2003, vol. 336, # 4-5, p. 258 - 263
Isoquinoline-4-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Isoquinoline-4-carboxylic acid manufacturers
- Product
- Isoquinoline-4-carboxylic acid 7159-36-6
- Price
- US $0.01-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50 tons
- Release date
- 2020-04-29
- Product
- Isoquinoline-4-carboxylic acid
- Price
- US $0.01-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50 tons
- Release date
- 2020-04-29
- Product
- Isoquinoline-4-carboxylic acid 7159-36-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-19