Isoquinoline-4-carbaldehyde
- Product Name
- Isoquinoline-4-carbaldehyde
- CAS No.
- 22960-16-3
- Chemical Name
- Isoquinoline-4-carbaldehyde
- Synonyms
- RARECHEM AK ML 0134;4-Formylisoquinoline;4-Isoquinolinecarbaldehyde;ISOQUINOLINE-4-CARBALDEHYDE;4-ISOQUINOLINECARBOXALDEHYDE;Isoquinoline-4-carboxaldehyde;4-Isoquinolinecarboxaldehyde 97%;Isoquinoline-4-carbaldehyde ,98%;4-Isoquinolinecarboxaldehyde (7CI,8CI,9CI);Isoquinoline-4-carbaldehyde ISO 9001：2015 REACH
- CBNumber
- CB3409590
- Molecular Formula
- C10H7NO
- Formula Weight
- 157.17
- MOL File
- 22960-16-3.mol
Isoquinoline-4-carbaldehyde Property
- Melting point:
- 101-106℃
- Boiling point:
- 331.7±15.0 °C(Predicted)
- Density
- 1.223±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- solid
- pka
- 3.49±0.10(Predicted)
- Appearance
- White to yellow Solid
- InChI
- InChI=1S/C10H7NO/c12-7-9-6-11-5-8-3-1-2-4-10(8)9/h1-7H
- InChIKey
- RNQQJLYJLDQGGL-UHFFFAOYSA-N
- SMILES
- C1C2=C(C=CC=C2)C(C=O)=CN=1
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36-36/37/38-20/21/22
- Safety Statements
- 26-36/37/39-22
- RIDADR
- 2811
- WGK Germany
- 3
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 737542
- Product name
- 4-Isoquinolinecarboxaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $120
- Updated
- 2023/06/20
- Product number
- I918263
- Product name
- Isoquinoline-4-carbaldehyde
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- I918263
- Product name
- Isoquinoline-4-carbaldehyde
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- OR60160
- Product name
- Isoquinoline-4-carboxaldehyde
- Packaging
- 250mg
- Price
- $24
- Updated
- 2021/12/16
- Product number
- 4H15-1-G1
- Product name
- Isoquinoline-4-carboxaldehyde
- Packaging
- 250mg
- Price
- $26
- Updated
- 2021/12/16
Isoquinoline-4-carbaldehyde Chemical Properties,Usage,Production
Chemical Properties
Off-white to yellow or brown solid
Synthesis
1532-97-4
68-12-2
22960-16-3
Under nitrogen protection, 4-bromoisoquinoline (2.0 g, 9.6 mmol) was dissolved in 30 mL of redistilled tetrahydrofuran (THF) and cooled to -65°C. n-Butyllithium (4.0 mL, 10 mmol, 2.5 M solution in THF) was added slowly and dropwise. Maintaining this temperature, the reaction mixture was stirred for 30 min. Subsequently, N,N-dimethylformamide (730 mg, 10 mmol) was added dropwise and stirring was continued for 1 h at the same temperature. After completion of the reaction, 100 mL of saturated aqueous ammonium chloride solution was added to the mixture. The reaction mixture was extracted with ethyl acetate (50 mL × 3). The organic layers were combined, washed with 100 mL of brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (elution gradient: 0-100% ethyl acetate/petroleum ether) to give isoquinoline-4-carboxaldehyde (550 mg, yellow solid, yield: 36%).1H NMR (400 MHz, CDCl3): δ 10.41 (s, 1H), 9.45 (s, 1H), 9.22 (d, J = 8.4 Hz, 1H) 8.96 (s, 1H), 8.10 (d, J = 8.4 Hz, 1H), 7.96-7.92 (m, 1H), 7.76 (t, J = 8.4 Hz, 1H).
References
[1] Tetrahedron, 1998, vol. 54, # 35, p. 10317 - 10328
[2] European Journal of Organic Chemistry, 2009, # 26, p. 4458 - 4467
[3] Patent: US2017/37050, 2017, A1. Location in patent: Paragraph 0346-0349
Isoquinoline-4-carbaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Isoquinoline-4-carbaldehyde manufacturers
- Product
- Isoquinoline-4-carbaldehyde 22960-16-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-13
- Product
- Isoquinoline-4-carbaldehyde 22960-16-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2023-03-04
- Product
- Isoquinoline-4-carbaldehyde 22960-16-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-10