ChemicalBook > CAS DataBase List > 5-Bromo-1,3-dichloro-2-fluorobenzene

5-Bromo-1,3-dichloro-2-fluorobenzene

Uses

Product Name: 5-Bromo-1,3-dichloro-2-fluorobenzene
CAS No.: 17318-08-0
Chemical Name: 5-Bromo-1,3-dichloro-2-fluorobenzene
Synonyms: 3-dichloro-2-fluorobenzene;3,5-Dichloro-4-fluorobromobenzene;3,5-dichloro-4-fluoro-1-bromobenzene;3,5-dichloro-4-fluorobroMobezene;3,5-dichloro-4-bromofluorobenzene;2,6-dichloro-4-bromofluorobenzene;5-Bromo-1,3-chloro-2-fluorobenzene;5-BROMO-1,3-DICHLORO-2-FLUOROBENZEN;1-BroMo-3,5-dichloro-4-fluorobenzene;3,5-dichllor-4-fluoro-1-bromobenzene
CBNumber: CB11462691
Molecular Formula: C6H2BrCl2F
Formula Weight: 243.89
MOL File: 17318-08-0.mol

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5-Bromo-1,3-dichloro-2-fluorobenzene Property

Boiling point:: 234℃
Density: 1.823
vapor pressure: 23.8-112Pa at 30-50℃
refractive index: 1.567
Flash point:: 96℃
storage temp.: Sealed in dry,2-8°C
form: Liquid
Appearance: Colorless to off-white <23°C Solid,>29°C Liquid
InChI: InChI=1S/C6H2BrCl2F/c7-3-1-4(8)6(10)5(9)2-3/h1-2H
InChIKey: MMJSIYGLDQNUTH-UHFFFAOYSA-N
SMILES: C1(Cl)=CC(Br)=CC(Cl)=C1F
LogP: 4.4 at 20℃ and pH7
CAS DataBase Reference: 17318-08-0

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Safety

HS Code: 2903998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B691093
Product name: 5-Bromo-1,3-dichloro-2-fluorobenzene
Packaging: 1g
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB37176
Product name: 5-Bromo-1,3-dichloro-2-fluorobenzene
Packaging: 10g
Price: $90
Updated: 2021/12/16

Apolloscientific

Product number: PC8928
Product name: 3,5-Dichloro-4-fluorobromobenzene
Packaging: 100g
Price: $51
Updated: 2021/12/16

SynQuest Laboratories

Product number: 1600-F-X5
Product name: 3,5-Dichloro-4-fluorobromobenzene
Packaging: 25g
Price: $61
Updated: 2021/12/16

Matrix Scientific

Product number: 074078
Product name: 5-Bromo-1,3-dichloro-2-fluorobenzene
Purity: 95+%
Packaging: 25g
Price: $69
Updated: 2021/12/16

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5-Bromo-1,3-dichloro-2-fluorobenzene Chemical Properties,Usage,Production

Uses

3,5-Dichloro-4-fluorobromobenzene is an organic synthesis intermediate that can be used in laboratory organic synthesis and pharmaceutical research and development.

Chemical Properties

light yellow liquid

Synthesis

60811-21-4

17318-08-0

The general procedure for the synthesis of 3,5-dichloro-4-fluorobromobenzene from 3-chloro-4-fluorobromobenzene was as follows: to a dry Schlenk flask equipped with a magnetic stirrer and septum under argon protection was added 20 mL of freshly titrated iPrMgCl-LiCl (1.24 M, THF solution, 1.0 equiv.), followed by a slow dropwise addition of 3.8 mL of diisopropylamine (1.1 equiv.) ). The reaction mixture was stirred at room temperature until complete gas release (~48 hours). The precipitate formed was dissolved with additional dry THF. A fresh solution of iPr2NMgCl-LiCl in THF was titrated at 25 °C using benzoic acid and 4-(phenylazo)diphenylamine as indicators, and the concentration was measured to be 0.59 M. 4-Bromo-2-chloro-1-fluorobenzene (0.209 g, 1.00 mmol) was dissolved in THF (1 mL) and iPr2NMgCl-LiCl (0.59 M , 3.39 mL, 2.00 mmol) solution was added and stirred at 25 °C for 15 min. Subsequently, hexachloro-2-acetone (0.397 g, 1.50 mmol) was added at 0 °C and stirring was continued for 15 min. The reaction mixture was quenched with saturated aqueous NaHCO3 solution, extracted with ethyl acetate and the organic phase was dried over anhydrous Na2SO4. After filtration, the solvent was concentrated under reduced pressure. Quantitative GC analysis showed the ratio of 5-bromo-1,3-dichloro-2-fluorobenzene to the regional isomers to be about 12:1. Purification by fast column chromatography (silica gel, n-hexane) afforded 5-bromo-1,3-dichloro-2-fluorobenzene (0.190 g) as a colorless oil.

References

[1] Patent: WO2016/58895, 2016, A1. Location in patent: Page/Page column 7; 8

5-Bromo-1,3-dichloro-2-fluorobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Bromo-1,3-dichloro-2-fluorobenzene manufacturers

.GZ HONESTCHEM CO.,LTD

Product: 5-Bromo-1,3-dichloro-2-fluorobenzene 17318-08-0
Price: US $1.00/g
Min. Order: 300g
Purity: 99.8%
Supply Ability: 20 TONS
Release date: 2025-11-04

Speranza Chemical Co., Ltd.

Product: 3,5-Dichloro-4-fluorobromobenzene 17318-08-0
Price: US $168.00/KG
Min. Order: 1KG
Purity: 98%+
Supply Ability: 300MT/year
Release date: 2019-12-24

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 5-Bromo-1,3-dichloro-2-fluorobenzene 17318-08-0
Price: US $45.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-12-25

17318-08-0, 5-Bromo-1,3-dichloro-2-fluorobenzeneRelated Search:

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5- bromo-1,3-dichloro-2-flurobenzene

5-Bromo-1,3-dichloro-2-fluorobenzene CAS NO.17318-08-0

5-Bromo-1,3-dichloro-2-fluorobenzene, 95%

2,6-dichloro-4-bromofluorobenzene

17318-08-0