METHYL 2,4-DIBROMOBENZOATE
- Product Name
- METHYL 2,4-DIBROMOBENZOATE
- CAS No.
- 54335-33-0
- Chemical Name
- METHYL 2,4-DIBROMOBENZOATE
- Synonyms
- 100125;Pramexol Impurity 67;METHYL 2,4-DIBROMOBENZOATE;2,4-Dibromo methyl benzoate;2,4-DibroMobenzoic Acid Methyl Ester;Benzoic acid, 2,4-dibroMo-, Methyl ester
- CBNumber
- CB11484651
- Molecular Formula
- C8H6Br2O2
- Formula Weight
- 293.94
- MOL File
- 54335-33-0.mol
METHYL 2,4-DIBROMOBENZOATE Property
- Boiling point:
- 308.0±22.0 °C(Predicted)
- Density
- 1.840±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D424500
- Product name
- 2,4-DibromobenzoicAcidMethylEster
- Packaging
- 250mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- HCH0360282
- Product name
- METHYL-2,4-DIBROMOBENZOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.87
- Updated
- 2021/12/16
- Product number
- 071177
- Product name
- Methyl 2,4-dibromobenzoate
- Purity
- 97%
- Packaging
- 5g
- Price
- $745
- Updated
- 2021/12/16
- Product number
- A127370
- Product name
- Methyl2,4-dibromobenzoate
- Purity
- 97%
- Packaging
- 1g
- Price
- $58
- Updated
- 2021/12/16
- Product number
- ES001530
- Product name
- Methyl2,4-Dibromobenzoate
- Purity
- 95%
- Packaging
- 1gm:
- Price
- $102.5
- Updated
- 2021/12/16
METHYL 2,4-DIBROMOBENZOATE Chemical Properties,Usage,Production
Uses
2,4-Dibromobenzoic Acid Methyl Ester is sued in the preparation of compounds with immunosuppressive inhibitory activity and antitumor activity.
Uses
2,4-Dibromobenzoic Acid Methyl Ester is used in the preparation of compounds with immunosuppressive inhibitory activity and antitumor activity.
Synthesis
67-56-1
611-00-7
54335-33-0
Step 1: In a 2L round-bottomed flask, 2,4-dibromobenzoic acid (250 g, 0.90 mol) was dissolved in methanol (2L) and concentrated sulfuric acid (18.4 g, 0.19 mol) was added. The reaction mixture was heated to reflux overnight and subsequently cooled to room temperature. The resulting precipitate was collected by filtration, washed with cold methanol and dried under vacuum to give 213.6 g of methyl 2,4-dibromobenzoate, the product was a yellow solid. Step 2: In another 2L round-bottomed flask, methyl 2,4-dibromobenzoate (200.7 g, 0.69 mol) was dissolved in 1L of anhydrous N,N-dimethylformamide (DMF). Copper cyanide (CuCN, 123.8 g, 1.38 mol) and sodium iodide (NaI, 22.8 g, 0.15 mol) were added sequentially. The reaction mixture was stirred at 160 °C overnight under nitrogen protection. Upon completion of the reaction, extraction was carried out with ethyl acetate (500 mL x 3), and the combined organic phases were washed with 500 mL of water. Purification by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=5/1) afforded 93.5 g of methyl 2,4-dicyanobenzoate, the product was a brown solid with 72.8% yield.
References
[1] Patent: EP3048103, 2016, A1. Location in patent: Paragraph 0077; 0078
[2] Beilstein Journal of Organic Chemistry, 2016, vol. 12, p. 2490 - 2494
[3] Chemistry - A European Journal, 2010, vol. 16, # 6, p. 1780 - 1784
[4] Asian Journal of Chemistry, 2014, vol. 26, # 19, p. 6655 - 6657
METHYL 2,4-DIBROMOBENZOATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL 2,4-DIBROMOBENZOATE manufacturers
- Product
- Methyl 2,4-dibromobenzoate 54335-33-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-25