L-BUTHIONINE-(S,R)-SULFOXIMINE
- Product Name
- L-BUTHIONINE-(S,R)-SULFOXIMINE
- CAS No.
- 83730-53-4
- Chemical Name
- L-BUTHIONINE-(S,R)-SULFOXIMINE
- Synonyms
- L-BSO;nsc326231;L-Butionine sulfoximine;L-BUTHIONINE-SULFOXIMINE;L-BUTHIONINESULPHOXIMINE;D-Buthionine Sulfoximine;Buthionine - sulfoxide iMine;L-BUTHIONINE-[S,R]-SULFOXIME;L-BUTHIONINE-S,R-SULPHOXIMINE;L-BUTHIONINE-(S,R)-SULFOXIMINE
- CBNumber
- CB1150667
- Molecular Formula
- C8H18N2O3S
- Formula Weight
- 222.31
- MOL File
- 83730-53-4.mol
L-BUTHIONINE-(S,R)-SULFOXIMINE Property
- Melting point:
- 224-228 °C (dec.)
- Boiling point:
- 382.3±52.0 °C(Predicted)
- Density
- 1.29
- refractive index
- 1.6300 (estimate)
- storage temp.
- -20°C
- solubility
- H2O: 50 mg/mL, clear, colorless to faintly yellow
- form
- Fine Powder
- color
- White
- BRN
- 2367136
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions are not stable and must be prepared fresh daily.
- CAS DataBase Reference
- 83730-53-4
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B2515
- Product name
- L-Buthionine-sulfoximine
- Purity
- ≥97% (TLC)
- Packaging
- 1g
- Price
- $444
- Updated
- 2024/03/01
- Product number
- B2515
- Product name
- L-Buthionine-sulfoximine
- Purity
- ≥97% (TLC)
- Packaging
- 5g
- Price
- $1560
- Updated
- 2024/03/01
- Product number
- 5.08228
- Product name
- L-ButhionineSulfoximine-CAS83730-53-4-Calbiochem
- Packaging
- 100mg
- Price
- $142
- Updated
- 2024/03/01
- Product number
- 14484
- Product name
- Buthionine Sulfoximine
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 14484
- Product name
- Buthionine Sulfoximine
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $286
- Updated
- 2024/03/01
L-BUTHIONINE-(S,R)-SULFOXIMINE Chemical Properties,Usage,Production
Description
L-Buthionine-(S,R)-sulfoximine is an irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM), the rate-limiting enzyme for L-glutathione (GSH) synthesis, that induces oxidative stress in cells by depleting GSH. Administration of L-buthionine-(S,R)-sulfoximine leads to decreased GSH levels in virtually all tissues and is associated with tissue damage and apoptosis. Whereas elevated glutathione levels are associated with tumor cell resistance, L-buthionine-(S,R)-sulfoximine has been shown to enhance the toxicity of various chemotherapeutic agents in drug-resistant tumors.
Chemical Properties
White Crystalline Solid
Uses
inhibitor of gamma-glutamylcysteine synthetase
Uses
Buthionine sulfoximine (BSO) is an irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM), the rate-limiting enzyme for L-glutathione (GSH) synthesis, that induces oxidative stress in cells by depleting GSH. Administration of BSO leads to decreased GSH levels in virtually all tissues and is associated with tissue damage and apoptosis. Whereas elevated glutathione levels are associated with tumor cell resistance, BSO has been shown to enhance the toxicity of various chemotherapeutic agents in drug-resistant tumors.
Uses
L-Buthionine-(S,R)-sulfoximine is a potent and specific inhibitor of alpha-glutamylcysteine synthetase.
Definition
ChEBI: L-buthionine-(S,R)-sulfoximine is a 2-amino-4-(S-butylsulfonimidoyl)butanoic acid which has S-configuration. It is a inhibitor of gamma-glutamylcysteine synthetase and glutathione (GSH) biosynthesis and is capable of enhancing the apoptotic effects of several chemotherapeutic agents. It has a role as a ferroptosis inducer and an EC 6.3.2.2 (glutamate--cysteine ligase) inhibitor.
Hazard
A reproductive hazard.
Biochem/physiol Actions
Blocks cellular resistance to chemotherapy by inhibiting γ-glutamylcysteine synthetase, a key enzyme in glutathione biosynthesis. Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.
storage
Store at -20°C
References
1) Lu?et al.?(2009),?Regulation of glutathione synthesis; Mol. Aspects Med.?30?42 2) Lee?et al.?(2008),?Adaptive response to GSH depletion and resistance to L-buthionine-(S,R)-sulfoximine; Mol. Cell Biochem.?12?174 3) Qiwei et al. (2016),?The effects of buthionine sulfoximine on the proliferation and apoptosis of biliary tract cancer cells induced by cisplatin and gemcitabine; Oncol. Lett.?11?474 4) Glasuer and Chandel (2014),?Targeting antioxidants for cancer therapy; Biochem. Pharmacol.?92?90
L-BUTHIONINE-(S,R)-SULFOXIMINE Preparation Products And Raw materials
Raw materials
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View Lastest Price from L-BUTHIONINE-(S,R)-SULFOXIMINE manufacturers
- Product
- L-BUTHIONINE-(S,R)-SULFOXIMINE 83730-53-4
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-10