4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE

Uses

Product Name: 4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE
CAS No.: 100644-65-3
Chemical Name: 4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE
Synonyms: o[3,4-d]pyrimidin-6-amine;6-Amino-4-chloropyrazolo[3,4-d]pyrimidine;4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE;1H-Pyrazolo[3,4-d]pyrimidin-6-amine,4-chloro-;4-chloro-1H-pyrazolo[3,4-d]pyrimidine-6-amine;6-Amino-4-chloro-1H-pyrazolo[3,4-d]pyrimidine;4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine;4-chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine(SALTDATA: FREE);4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE ISO 9001：2015 REACH
CBNumber: CB11511315
Molecular Formula: C5H4ClN5
Formula Weight: 169.57
MOL File: 100644-65-3.mol

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4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE Property

Boiling point:: 282.3±50.0 °C(Predicted)
Density: 2.09±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 9.35±0.20(Predicted)
Appearance: Light yellow to yellow Solid
InChI: InChI=1S/C5H4ClN5/c6-3-2-1-8-11-4(2)10-5(7)9-3/h1H,(H3,7,8,9,10,11)
InChIKey: ASKOHPBJRRSUSJ-UHFFFAOYSA-N
SMILES: C1(N)=NC(Cl)=C2C=NNC2=N1

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Safety

RIDADR: UN2811
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C383640
Product name: c4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: C383640
Product name: c4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine
Packaging: 500mg
Price: $130
Updated: 2021/12/16

Matrix Scientific

Product number: 067148
Product name: 4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine
Packaging: 500mg
Price: $135
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC54427
Product name: c4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine
Packaging: 50mg
Price: $85
Updated: 2021/12/16

AK Scientific

Product number: X8516
Product name: 4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine
Packaging: 250mg
Price: $100
Updated: 2021/12/16

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4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE Chemical Properties,Usage,Production

Uses

4-Chloro-1H-pyrazolo[3,4-D]pyrimidine-6-amine is a pyrimidine derivative that can be used as a pharmaceutical intermediate.

Synthesis

5604-46-6

100644-65-3

GENERAL STEPS: A mixture of 2-amino-4,6-dichloropyrimidine-5-carbaldehyde (1.92 g, 10 mmol) and triethylamine (1.59 mL, 11.5 mmol) was added to a solvent mixture of THF (40 mL) and H2O (4 mL) at room temperature. Subsequently, hydrazine (64%, 486 μL, 10 mmol) was added slowly and dropwise. The reaction mixture was stirred continuously for 4 h at room temperature. Upon completion of the reaction, the volatiles were removed by distillation under reduced pressure. The residue was precipitated with water, and the resulting precipitate was washed with water and dried under vacuum to afford the target product 4-chloro-1H-pyrazolo[3,4-D]pyrimidin-6-amine (1.8 g, quantitatively) as a yellow solid.13C NMR (DMSO-d6, 75 MHz) δ: 161.5 (C-2), 157.5 (C-4), 153.2 (C-7a), 132.7 (C-5), 105.8 (C-4a).MS (m/z): 170 [M + H]+.

References

[1] Patent: WO2014/96423, 2014, A1. Location in patent: Page/Page column 50
[2] Patent: CN103804447, 2016, B. Location in patent: Paragraph 0076; 0082; 0083; 0084
[3] Synlett, 2011, # 13, p. 1900 - 1904
[4] Patent: WO2012/135084, 2012, A1. Location in patent: Page/Page column 17
[5] Patent: US2012/202785, 2012, A1. Location in patent: Page/Page column 262

4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE Suppliers

China 102 Germany 1 India 4 United Kingdom 2 United States 13 Global 122

ShangHai Movin Pharmaceutical Co., Ltd.

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Adamas Reagent, Ltd.

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Accela ChemBio Co.,Ltd.

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Chemsky（shanghai）International Co.,Ltd.

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Santai Labs, Inc.

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Shanghai Ennopharm Co., Ltd.

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QINGDAO CARELONGPHARMATECH CO.,LTD

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NovoChemy Ltd.

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Nantong Ayeschem Co., Ltd

Tel: +86-513-86760116
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View Lastest Price from 4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE 100644-65-3
Price: US $5.00/g
Min. Order: 1g
Purity: 97%
Supply Ability: 100kg
Release date: 2025-03-31

Dideu Industries Group Limited

Product: 4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE 100644-65-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons
Release date: 2022-02-10

Career Henan Chemical Co

Product: 4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE 100644-65-3
Price: US $5.50/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1kg-100kg
Release date: 2020-01-14

100644-65-3, 4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINERelated Search:

2'-Deoxyadenosine Bithionol Octamethylcyclotetrasiloxane 4-Chloro-3H-[1,2,3]triazolo[4,5-c]pyridine methyl 4-chloro-1H-pyrazole-5-carboxylate(SALTDATA: FREE) 4-CHLORO (1H)INDAZOLE 4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one 4-c]pyridine 4-CHLORO-1H-INDAZOL-3-AMINE 4-Chloro-1H-pyrazol-3-amine 4-Bromo-1H-pyrrolo[2,3-b]pyridin-2(3H)-one 4-CHLORO-1H-INDOL-3-METHYLAMINE 4-CHLORO-1H-PYRAZOLE-3-CARBOXYLIC ACID 4-Chloro-1H-pyrazolo[3,4-d]pyrimidine 4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE

4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE

4-Chloro-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine

4-chloro-1H-pyrazolo[3,4-d]pyrimidin-6-amine(SALTDATA: FREE)

6-Amino-4-chloro-1H-pyrazolo[3,4-d]pyrimidine

6-Amino-4-chloropyrazolo[3,4-d]pyrimidine

1H-Pyrazolo[3,4-d]pyrimidin-6-amine,4-chloro-

o[3,4-d]pyrimidin-6-amine

4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE ISO 9001：2015 REACH

4-chloro-1H-pyrazolo[3,4-d]pyrimidine-6-amine

100644-65-3