4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

Uses

Product Name: 4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one
CAS No.: 346599-62-0
Chemical Name: 4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one
Synonyms: 4-chloro-1H-pyrrolo[2;3-b]pyridin-2(3H)-one;4-Chloro-7-aza-2-oxindole;4-Chloro-1H-pyrrolo[2,3-b...;4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;4-chloro-1H,2H,3H-pyrrolo[2,3-b]pyridin-2-one;4-Chloro-1,3-dihydropyrrolo[2,3-b]pyridin-2-one;2H-Pyrrolo[2,3-b]pyridin-2-one, 4-chloro-1,3-dihydro-
CBNumber: CB71856119
Molecular Formula: C7H5ClN2O
Formula Weight: 168.58
MOL File: 346599-62-0.mol

More

Less

4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one Property

Boiling point:: 373.0±42.0 °C(Predicted)
Density: 1.450±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
pka: 11.65±0.20(Predicted)
Appearance: White to light brown Solid
InChI: InChI=1S/C7H5ClN2O/c8-5-1-2-9-7-4(5)3-6(11)10-7/h1-2H,3H2,(H,9,10,11)
InChIKey: MUJHLWISGAWFPZ-UHFFFAOYSA-N
SMILES: C12NC(=O)CC1=C(Cl)C=CN=2

More

Less

Safety

RIDADR: UN2811
HS Code: 2933998090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

TRC

Product number: C381665
Product name: 4-Chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one
Packaging: 500mg
Price: $155
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 35755
Product name: 4-Chloro-1H-pyrrolo[2,3-β]pyridin-2(3H)-one
Purity: 95+%
Packaging: 250mg
Price: $438
Updated: 2021/12/16

Matrix Scientific

Product number: 068703
Product name: 4-Chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one
Purity: >95%
Packaging: 1g
Price: $445
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H48-5-BG
Product name: 4-Chloro-1H,2H,3H-pyrrolo[2,3-b]pyridin-2-one
Purity: 97.0%
Packaging: 250mg
Price: $290
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H48-5-BG
Product name: 4-Chloro-1H,2H,3H-pyrrolo[2,3-b]pyridin-2-one
Purity: 97.0%
Packaging: 1g
Price: $790
Updated: 2021/12/16

More

Less

4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one Chemical Properties,Usage,Production

Uses

4-Chloro-1H-pyrrolo[2,3-B]pyridine-2(3H)-one is a ketone derivative that can be used as a pharmaceutical intermediate.

Synthesis

346600-25-7

346599-62-0

To a solution of 3,3-dibromo-4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one (350 mg, 1.072 mmol) in methanol (5 mL) was added acetic acid (5 mL), followed by addition of zinc powder (351 mg, 5.36 mmol) in batches. The reaction mixture was stirred at room temperature for 1 hour. After completion of the reaction, the mixture was diluted with ethyl acetate (50 mL) and filtered through diatomaceous earth. The filtrate was neutralized with 10% aqueous sodium bicarbonate. The organic layer was separated, dried over anhydrous sodium sulfate, filtered and concentrated to give a brown solid. The solid was washed with hexane (2 x 20 mL) to afford 4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one (164 mg, 0.973 mmol, 91% yield) as an off-white solid. lcms (ESI) m/z 168.9 [M+H]+ (calculated value C7H6ClN2O, 169.01); lc/ms retention time (Method B): tR = 0.58 min.

References

[1] Patent: WO2017/59080, 2017, A1. Location in patent: Page/Page column 122
[2] Patent: WO2007/125325, 2007, A1. Location in patent: Page/Page column 86-87
[3] Patent: WO2007/125320, 2007, A1. Location in patent: Page/Page column 135
[4] Patent: US2002/183319, 2002, A1
[5] Patent: WO2014/713, 2014, A1. Location in patent: Page/Page column 42

4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one Suppliers

China 88 Germany 1 India 1 United Kingdom 1 United States 11 Global 102

Suzhou Dongji Chemical Technology Co., Ltd.

Tel: 18516099287
Email: 3045383737@qq.com
Country: China
ProdList: 230
Advantage: 58

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Shangchem Co., Ltd.

Tel: +86-21-68182121
Fax: +86-21-68182121
Country: China
ProdList: 882
Advantage: 52

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Shanghai Boc Chemical Co.,Ltd

Tel: 021-34975603-808 18721111801
Fax: +86-21-34975602-805
Email: sales@bocpharma.com
Country: China
ProdList: 1009
Advantage: 64

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

SpringPharma Tech Co.,Ltd

Tel: +86-25-68710855, +86-25-68710897
Fax: 025-68710856
Email: sales@springpharma.net
Country: China
ProdList: 1261
Advantage: 62

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Wuhan TCASChem Technology Co., Ltd.

Tel: 027-86697669 13986148687
Fax: 86-027-86697669
Email: sales@tcaschem.com
Country: China
ProdList: 3993
Advantage: 55

More

Less

View Lastest Price from 4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one manufacturers

Career Henan Chemical Co

Product: 4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one 346599-62-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-31

346599-62-0, 4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-oneRelated Search:

Bromothymol Blue CPNQ Vitamin B series 4-Chloro-3H-[1,2,3]triazolo[4,5-c]pyridine methyl 4-chloro-1H-pyrazole-5-carboxylate(SALTDATA: FREE) 4-CHLORO (1H)INDAZOLE 4-c]pyridine 4-CHLORO-1H-INDAZOL-3-AMINE 4-Chloro-1H-pyrazol-3-amine 4-Bromo-1H-pyrrolo[2,3-b]pyridin-2(3H)-one 4-CHLORO-1H-INDOL-3-METHYLAMINE 4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-AMINE 4-CHLORO-1H-PYRAZOLE-3-CARBOXYLIC ACID

4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one

4-Chloro-1H-pyrrolo[2,3-b...

4-Chloro-7-aza-2-oxindole

3-b]pyridin-2(3H)-one

4-chloro-1H-pyrrolo[2

4-chloro-1H,2H,3H-pyrrolo[2,3-b]pyridin-2-one

2H-Pyrrolo[2,3-b]pyridin-2-one, 4-chloro-1,3-dihydro-

4-Chloro-1,3-dihydropyrrolo[2,3-b]pyridin-2-one

346599-62-0

CHIRAL CHEMICALS