ChemicalBook > CAS DataBase List > 4-METHOXYCINNAMIC ACID

4-METHOXYCINNAMIC ACID

Product Name
4-METHOXYCINNAMIC ACID
CAS No.
943-89-5
Chemical Name
4-METHOXYCINNAMIC ACID
Synonyms
PMCA;AKOS B000181;AKOS BB/0034;AKOS BBS-00000769;TIMTEC-BB SBB005717;RARECHEM BK HC T257;OTAVA-BB BB0123400502;4-Methoxycinnamic acid;LABOTEST-BB LT00108121;O-METHYL-P-CUMARIC ACID
CBNumber
CB1152939
Molecular Formula
C10H10O3
Formula Weight
178.18
MOL File
943-89-5.mol
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4-METHOXYCINNAMIC ACID Property

Melting point:
173.5 °C(lit.)
Boiling point:
342.6±17.0 °C(Predicted)
Density 
1.195±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in ethanol, ethyl acetate and other organic solvents.
pka
4.60±0.10(Predicted)
form 
powder to crystal
color 
White to Almost white
BRN 
510468
InChIKey
AFDXODALSZRGIH-QPJJXVBHSA-N
LogP
1.264 (est)
CAS DataBase Reference
943-89-5(CAS DataBase Reference)
NIST Chemistry Reference
2-Propenoic acid, 3-(4-methoxyphenyl)-, (e)-(943-89-5)
EPA Substance Registry System
2-Propenoic acid, 3-(4-methoxyphenyl)-, (2E)- (943-89-5)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
WGK Germany 
3
RTECS 
UD3391300
8
TSCA 
Yes
HS Code 
2918.29.7500
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M0576
Product name
trans-4-Methoxycinnamic Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$31
Updated
2024/03/01
TCI Chemical
Product number
M0576
Product name
trans-4-Methoxycinnamic Acid
Purity
>98.0%(GC)(T)
Packaging
100g
Price
$77
Updated
2024/03/01
Alfa Aesar
Product number
A13870
Product name
trans-4-Methoxycinnamic acid
Purity
98%
Packaging
10g
Price
$21.65
Updated
2024/03/01
Alfa Aesar
Product number
A13870
Product name
trans-4-Methoxycinnamic acid
Purity
98%
Packaging
50g
Price
$80.65
Updated
2024/03/01
Alfa Aesar
Product number
A13870
Product name
trans-4-Methoxycinnamic acid
Purity
98%
Packaging
250g
Price
$336.65
Updated
2024/03/01
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4-METHOXYCINNAMIC ACID Chemical Properties,Usage,Production

Uses

Esters derived from trans-4-methoxycinnamic acid are effective absorbers of UV radiation. The starting material was trans-4-methoxycinnamic acid and 3,5dimethoxybenzoic acid methyl ester in isolated avenanthramide alkaloids synthsis. trans-4-Methoxycinnamic acid was converted into its acid chloride (yield 98%) with thionyl chloride. Employed in organic synthesis of pharmaceutical intermediates, synthetic anti-adrenergic drugs esmolol, cosmetics ultraviolet absorption.

Preparation

4-methoxycinnamic acid synthesis : In a 25-mL, roundbottomed flask, 4-methoxybenzaldehyde (0.804 mL, 6.61 mmol) (3), malonic acid (1.75 g, 16.8 mmol), and β-alanine (0.10 g, 1.12 mmol) were dissolved in pyridine (3.0 mL, 37.1 mmol) and heated under reflux for 90 minutes. After cooling to room temperature, the reaction mixture was placed in an ice bath and 8.0 mL of concentrated HCl was slowly added. The resulting white precipitate was collected by vacuum filtration, washed with cold water (2 x 10mL) and dried thoroughly. The product was recrystallized from absolute ethanol (~20 mL).
Synthesis of 4-methoxycinnamic acid

Definition

ChEBI: 4-methoxycinnamic acid is a methoxycinnamic acid having a single methoxy substituent at the 4-position on the phenyl ring. It is functionally related to a cinnamic acid.

Purification Methods

Crystallise the acid from MeOH to constant melting point and UV spectrum. [Beilstein 10 IV 1005.]

4-METHOXYCINNAMIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-METHOXYCINNAMIC ACID manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-METHOXYCINNAMIC ACID 943-89-5
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2024-08-28
Shaanxi Dideu Medichem Co. Ltd
Product
(E)-4-Methoxycinnamic Acid 943-89-5
Price
US $1.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50 tons
Release date
2020-01-20
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
Product
4-methoxycinnamicacid 943-89-5
Price
US $25.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
20 tons
Release date
2021-12-31

943-89-5, 4-METHOXYCINNAMIC ACIDRelated Search:


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  • trans-4-Methoxycinnamic acid, 98+%
  • (E)-4-Methoxycinnamic acid
  • 4-Methoxy-trans-cinnamic acid
  • p-Methoxy-trans-cinnamic acid
  • 4-Methoxycinnamic acid >=98.0% (GC)
  • trans-4-MethoxyClnnamic acid
  • 4-Methoxycinnamic acid
  • RARECHEM BK HC T257
  • TIMTEC-BB SBB005717
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  • OTAVA-BB BB0123400502
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  • AKOS B000181
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  • LABOTEST-BB LT00108121
  • (E)-3-(4-METHOXYPHENYL)ACRYLIC ACID
  • 3-(4-METHOXY-PHENYL)-ACRYLIC ACID
  • (2E)-3-(4-METHOXYPHENYL)ACRYLIC ACID
  • (E)-p-methoxycinnamic acid
  • 2-Propenoic acid, 3-(4-methoxyphenyl)-, (2E)-
  • 2-Propenoic acid, 3-(4-methoxyphenyl)-, (E)-
  • (E)-4-MethoxycinnamicAci
  • trans-O-Methyl-p-coumaric Acid
  • (E)-3-(4-methoxyphenyl)prop-2-enoic acid
  • 943-89-5 RARECHEM BK HC T257
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  • 943-89-5
  • 786-13-1
  • Exciton Chirality CD Method (for Hydroxyl Groups)
  • Absolute Conefiguration Determination (Exciton Chirality CD Method)
  • Chalcones, etc. (Building Blocks for Liquid Crystals)
  • Enantiomer Excess & Absolute Conefiguration Determination
  • Building Blocks for Liquid Crystals
  • Carboxylic Acids
  • Carbonyl Compounds
  • C10
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  • Benzenes
  • 943-89-5