ChemicalBook > CAS DataBase List > BOC-CYS-OH

BOC-CYS-OH

Product Name
BOC-CYS-OH
CAS No.
20887-95-0
Chemical Name
BOC-CYS-OH
Synonyms
BOC-CYS-OH;BOC-L-CYS-OH;BOC-L-CYSTEINE;N-Boc-L-cysteine;Boc-Cys-Cysteine;BOC-CYS-OH USP/EP/BP;N-ALPHA-T-BOC-L-CYSTEINE;Boc-Cys-OH,Boc-L-cysteine;Boc-L-cysteine≥ 98% (HPLC);Boc-Cys-OH (cryst) Novabiochem
CBNumber
CB1153365
Molecular Formula
C8H15NO4S
Formula Weight
221.27
MOL File
20887-95-0.mol
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BOC-CYS-OH Property

Melting point:
67-70°C
Boiling point:
361.4±37.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol
form 
Solid
pka
3.57±0.10(Predicted)
color 
White to Off-White
optical activity
[α]20/D +8.0±1.5°, c = 1% in ethanol
BRN 
2450705
InChI
InChI=1S/C8H15NO4S/c1-8(2,3)13-7(12)9-5(4-14)6(10)11/h5,14H,4H2,1-3H3,(H,9,12)(H,10,11)/t5-/m0/s1
InChIKey
ATVFTGTXIUDKIZ-YFKPBYRVSA-N
SMILES
C(O)(=O)[C@H](CS)NC(OC(C)(C)C)=O
CAS DataBase Reference
20887-95-0(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H372Causes damage to organs through prolonged or repeated exposure

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.53031
Product name
Boc-Cys-OH (cryst)
Purity
Novabiochem?
Packaging
5G
Price
$266
Updated
2025/07/31
Sigma-Aldrich
Product number
8.53031
Product name
Boc-Cys-OH (cryst)
Purity
Novabiochem?
Packaging
25G
Price
$982
Updated
2023/06/20
Sigma-Aldrich
Product number
15411
Product name
Boc-Cys-OH
Purity
for chiral derivatization, ≥98.5%
Packaging
250mg
Price
$84
Updated
2022/05/15
Sigma-Aldrich
Product number
15411
Product name
Boc-Cys-OH
Purity
for chiral derivatization, ≥98.5%
Packaging
1g
Price
$314
Updated
2022/05/15
Usbiological
Product number
264624
Product name
Boc-L-cysteine
Packaging
1g
Price
$319
Updated
2021/12/16
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BOC-CYS-OH Chemical Properties,Usage,Production

Chemical Properties

light yellowliquid

Uses

Boc-L-cysteine is the protected form of L-Cysteine (C995000), a non-essential α-amino acid that is biosynthesized in humans. L-Cysteine is also a bicarbonate-sensitive endogenous excitotoxin in rats and possibly humans.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

10389-65-8

20887-95-0

General procedure for the synthesis of (R)-2-((tert-butoxycarbonyl)amino)-3-mercaptopropionic acid from N,N'-bis(Boc)-L-cystine: N,N'-bis(Boc)-L-cystine (2.51 mmol) was dissolved in a solvent mixture of tetrahydrofuran (29.2 mL) and water (0.8 mL). Tributylphosphine (2.76 mmol) was added to the solution under ice bath cooling conditions. The reaction mixture was gradually warmed up to room temperature and stirred continuously at this temperature for 1 hour. Upon completion of the reaction, ethyl acetate (20 mL) and 10% aqueous citric acid (10 mL) were added to the reaction mixture for extraction and separation. The organic phase was collected and washed with saturated aqueous saline solution (20 mL). Subsequently, the organic phase was concentrated and the resulting residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate mixed solvent) to afford the target compound 22 as an oily product. Yield: 99%. ESI MS m/z 220.1 [M-H]-; 1H NMR (400 MHz, CDCl3) δ: 5.47 (1H, brs), 4.65 (1H, brs), 3.09-2.97 (2H, m), 1.48 (9H, s).

References

[1] Patent: US2012/282386, 2012, A1. Location in patent: Page/Page column 15
[2] Journal of Nanoparticle Research, 2017, vol. 19, # 6,
[3] Angewandte Chemie, 1993, vol. 105, # 2, p. 311 - 313
[4] Chemische Berichte, 1969, vol. 102, p. 1048 - 1052
[5] Protein and Peptide Letters, 2014, vol. 21, # 12, p. 1257 - 1264

BOC-CYS-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-CYS-OH Suppliers

China 144 Germany 5 India 3 Japan 3 South Korea 1 Switzerland 2 United Kingdom 4 United States 24 Global 186
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View Lastest Price from BOC-CYS-OH manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
BOC-CYS-OH 20887-95-0
Price
US $2.60/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000kg
Release date
2024-08-09
Zhuozhou Wenxi import and Export Co., Ltd
Product
BOC-CYS-OH 20887-95-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
BOC-CYS-OH 20887-95-0
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-08-31

20887-95-0, BOC-CYS-OHRelated Search:

BOC-CYS(ET)-OH BOC-CYS-OH BOC-CYS(4-MEOBZL)-OH BOC-S-TERT-BUTYLMERCAPTO-L-CYSTEINE BOC-CYS(ME)-OH BOC-L-THIAZOLIDINE-4-CARBOXYLIC ACID BOC-CYS(ACM)-OH BOC-PEN(MOB)-OH Boc-S-Benzyl-L-cysteine Boc-S-(4-methylbenzyl)-L-cysteine (Boc-Cys-OH)2 (Disulfide bond),(BOC-CYS-OH)2 N-Boc-S-Trityl-L-cysteine BOC-CYS(DPM)-OH BOC-CYS(TBU)-OH BOC-CYS(FM)-OH BOC-S-(4-METHOXYBENZYL)-L-CYSTEINE DICYCLOHEXYLAMINE SALT BOC-CYS(BZL)-ONP BOC-CYS(3,4-DIMETHYLBENZYL)-OH

  • N-[(tert-Butyloxy)carbonyl]-L-cysteine
  • (S)-2-tert-Butoxycarbonylamino-3-mercapto-propionic acid
  • (2R)-2-(tert-butoxycarbonylamino)-3-mercapto-propionic acid
  • (2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-sulfanylpropanoic acid
  • (2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-sulfanyl-propanoic acid
  • Boc-Cys-OH,Boc-L-cysteine
  • (2R)-2-[(tert-butoxycarbonyl)aMino]-3-sulfanylpropanoic acid
  • N-Boc-L-cysteine
  • (R)-2-((tert-butoxycarbonyl)aMino)-3-Mercaptopropanoic acid
  • Boc-L-cysteine, for chiral derivatization
  • Boc-L-cysteine≥ 98% (HPLC)
  • Boc-Cys-OH (cryst) Novabiochem
  • N-ALPHA-T-BUTOXYCARBONYL-L-CYSTEINE
  • N-ALPHA-T-BUTYLOXYCARBONYL-L-CYSTEINE
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-L-CYSTEINE
  • N-ALPHA-T-BOC-L-CYSTEINE
  • BOC-CYS-OH
  • BOC-L-CYSTEINE
  • BOC-L-CYS-OH
  • N-(tert-Butoxycarbonyl)-L-cysteine
  • N-tert-butyloxycarbonylcysteine
  • N-(tert-Butyloxycarbonyl)-L-cysteine
  • Boc-L-cysteine, 98%, for chiral derivatization
  • L-Cysteine, N-[(1,1-dimethylethoxy)carbonyl]-
  • (2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-sulfanylpropanoicaci
  • BOC-CYS-OH USP/EP/BP
  • Boc-Cys-Cysteine
  • (2R)-2-(tert-butoxycarbonylamino)-3-sulfanyl-propanoic acid - [B84635]
  • 20887-95-0
  • Cysteine/Cystine
  • Specialty Synthesis
  • Peptide Synthesis
  • Amino Acid Derivatives
  • Boc-Amino acid series
  • Amino Acids
  • Pharmaceutical Intermediates