N-Boc-S-Trityl-L-cysteine

Product Name: N-Boc-S-Trityl-L-cysteine
CAS No.: 21947-98-8
Chemical Name: N-Boc-S-Trityl-L-cysteine
Synonyms: Boc-Cys(Trt);BOC-L-CYS(TRT)-OH;Boc-S-Trityl-Cys-OH;Boc-Cys(Trt)-OH 97%;BOC-CYSTEINE(TRT)-OH;Boc-Cys(Trt)-OH, >=98%;BOC-L-CYSTEINE(TRITYL);N-Boc-S-Trityl-L-Cys-OH;BOC-L-TRITYL-L-CYSTEINE;BOC-S-TRITYL-L-CYSTEINE
CBNumber: CB4355333
Molecular Formula: C27H29NO4S
Formula Weight: 463.59
MOL File: 21947-98-8.mol

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N-Boc-S-Trityl-L-cysteine Property

Melting point:: 143-146 °C(lit.)
alpha: 27.5 º (c=1, EtOH)
Boiling point:: 610.9±55.0 °C(Predicted)
Density: 1.200±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 3.82±0.10(Predicted)
color: White to off-white
optical activity: [α]20/D +27.5°, c = 1 in ethanol
BRN: 2028965
InChIKey: JDTOWOURWBDELG-QHCPKHFHSA-N
SMILES: C(O)(=O)[C@H](CSC(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1)NC(OC(C)(C)C)=O
CAS DataBase Reference: 21947-98-8(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
F: 3-10
HS Code: 2930 90 16

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.53005
Product name: Boc-Cys(Trt)-OH
Purity: Novabiochem?
Packaging: 25g
Price: $272
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.53005
Product name: Boc-Cys(Trt)-OH
Purity: Novabiochem?
Packaging: 100g
Price: $822
Updated: 2025/07/31

Sigma-Aldrich

Product number: 459313
Product name: Boc-Cys(Trt)-OH
Purity: 97%
Packaging: 5g
Price: $75.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 459313
Product name: Boc-Cys(Trt)-OH
Purity: 97%
Packaging: 25g
Price: $220.5
Updated: 2025/07/31

Usbiological

Product number: 236703
Product name: Boc-S-trityl-L-cysteine 99+%
Packaging: 1g
Price: $156
Updated: 2021/12/16

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N-Boc-S-Trityl-L-cysteine Chemical Properties,Usage,Production

Chemical Properties

White to yellow crystalline powder

Uses

Boc-Cys(Trt)-OH is used in method for preparing ularitide.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

2799-07-7

21947-98-8

General procedure for the synthesis of N-tert-butoxycarbonyl-S-trityl-L-cysteine from di-tert-butyl dicarbonate (Boc2O) and S-trityl-L-cysteine: S-trityl-L-cysteine (5 g, 12.7 mmol) was dissolved in 2N NaOH solution (80 mL), followed by the addition of di-tert-butyl dicarbonate (4.5 g, 20 mmol) . The reaction mixture was stirred at room temperature for 24 hours. After completion of the reaction, the aqueous solution was acidified to pH 2 with concentrated hydrochloric acid and then extracted with dichloromethane (2 x 100 mL). The organic phases were combined, washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target compound N-tert-butoxycarbonyl-S-trityl-L-cysteine (5.3 g, 90% yield) as a white foamy solid without further purification.1H NMR (DMSO-d6) δ: 1.37 (s, 9H, tert-butyl-CH3); 2.29-2.58 (m , 2H, CH2); 3.76-3.79 (m, 1H, CH); 6.84 (d, J=7.8Hz, 1H, NH); 7.14-7.38 (m, 15H, triphenylmethyl-H).MALDI-TOF MS: m/z 464.8 [M+H]+, molecular weight 463.59 for calculated value C27H29NO4S.

References

[1] European Journal of Medicinal Chemistry, 2012, vol. 50, p. 383 - 392
[2] Chemical Communications, 2013, vol. 49, # 92, p. 10808 - 10810
[3] Patent: CN106432014, 2017, A. Location in patent: Paragraph 0096; 0100; 0101; 0102; 0142; 0146; 0147; 0148
[4] Patent: WO2009/137251, 2009, A2. Location in patent: Page/Page column 30; 31
[5] Chemistry of Natural Compounds, 1979, vol. 15, p. 471 - 476

N-Boc-S-Trityl-L-cysteine Preparation Products And Raw materials

Raw materials

Sodium acetate N,N-Dimethylformamide Acetone Di-tert-butyl dicarbonate Triethylamine 1,4-Dioxane L-Cysteine monohydrochloride Triphenylmethyl Chloride Citric acid

Preparation Products

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N-Boc-S-Trityl-L-cysteine Suppliers

China 256 Europe 3 Germany 6 India 7 Japan 4 Poland 1 South Korea 1 Switzerland 4 United Kingdom 11 United States 42 Global 335

Shandong fen Boyu Biotechnology Co.,LTD

Tel: 13356310019 13356310019;
Email: boyu2024@163.com
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Alfa Aesar

Tel: 400-6106006
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Email: saleschina@alfa-asia.com
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TAIYUAN RHF CO.,LTD.

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Energy Chemical

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Tel: 21-61263452 13641803416
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Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

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View Lastest Price from N-Boc-S-Trityl-L-cysteine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-Cys(Trt)-OH 21947-98-8
Price: US $0.00-0.00/kgkg
Min. Order: 1kgkg
Purity: 98%
Supply Ability: 1T+
Release date: 2023-09-20

Honest Joy Holdings Limited

Product: Boc-Cys(Trt)-OH 21947-98-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.5%
Supply Ability: 100 tons
Release date: 2022-01-26

Career Henan Chemical Co

Product: N-Boc-S-Trityl-L-cysteine 21947-98-8
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-08-07

21947-98-8, N-Boc-S-Trityl-L-cysteineRelated Search:

Triphenylmethyl Chloride 1,1'-Carbonyldiimidazole Boc-S-(4-methylbenzyl)-L-cysteine N-Carbobenzyloxyglycine POLY(METHYLSILSESQUIOXANE) tert-Butyl carbazate tert-Butanol Trityl candesartan cilexetil L-Cysteine PENICILLIN V Carbonyl iron powder S-Trityl-L-cysteine Boc-S-trityl-D-cysteine BOC-S-TRITYL-D-CYSTEINE,N-ALPHA-T-BOC-S-TRITYL-D-CYSTEINE,BOC-D-TRITYL-L-CYSTEINE BOC-S-TRITYL-L-CYSTEINE N-HYDROXYSUCCINIMIDE ESTER BOC-PEN(TRT)-OH BOC-D-PEN(TRT)-OH N-Boc-S-Trityl-L-cysteine

Boc-S-Trityl-Cys-OH

N-(tert-Butyloxycarbonyl)-S-trityl-L-cysteine

N-[(1,1-Dimethylethoxy)carbonyl]-S-(triphenylmethyl)-L-cysteine

N-Boc-S-Trityl-L-Cys-OH

BOC-S-trityl-L-cysteine,99%

2-(tert-butoxycarbonylamino)-3-[tri(phenyl)methylthio]propionic acid

2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-[tri(phenyl)methylsulfanyl]propanoic acid

L-Cysteine, N-[(1,1-dimethylethoxy)carbonyl]-S-(triphenylmethyl)-

N-(tert-Butoxycarbonyl)-S-trityl-L-cysteine ,99%

N-Boc-S-triphenylMethyl-L-cysteine

tert-butyl N-[(2R)-3-oxo-4,4,4-triphenyl-1-sulfanylbutan-2-yl]carbaMate

Boc-S-trityl-L-cysteine≥ 99.5% (HPLC, Chiral purity)

Boc-Cys(Trt)-OH 97%

Boc-Cys(Trt)-OH, >=98%

Nα-Boc-S-trityl-L-cysteine, N-(tert-Butoxycarbonyl)-S-trityl-L-cysteine

(R)-2-((tert-Butoxycarbonyl)aMino)-3-(tritylthio)propanoic acid

BOC-L-TRITYL-L-CYSTEINE

(2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-tritylsulfanylpropanoic acid

(2R)-2-{[(tert-butoxy)carbonyl]amino}-3-[(triphenylmethyl)sulfanyl]propanoic acid

(2R)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-3-[(triphenylmethyl)thio]propanoic acid

BOC-L-CYSTEINE(TRITYL)

BOC-L-CYS(TRT)-OH

BOC-CYSTEINE(TRT)-OH

BOC-S-TRITYL-L-CYSTEINE

(R)-2-TERT-BUTOXYCARBONYLAMINO-3-TRITYLSULFANYL-PROPIONIC ACID

N-(TERT-BUTOXYCARBONYL)-S-TRITYL-L-CYSTEINE

N-BOC-S-TRITYL-L-CYSTEINE

N-ALPHA-T-BOC-S-TRITYL-L-CYSTEINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-S-TRITYL-L-CYSTEINE

N-ALPHA-T-BUTOXYCARBONYL-S-TRITYL-L-CYSTEINE

N-ALPHA-T-BUTYLOXYCARBONYL-S-TRITYL-L-CYSTEINE

N-ALPHA-BOC-S-TRITYL-L-CYSTEINE

N<SUB>α</SUB>-Boc-S-trityl-L-cysteine

N-T-boc-S-trityl-L-cysteine crystalline

Boc-Cys(Trt)

NALPHA-tert-Butoxycarbonyl-S-trityl-L-cysteine

(Tert-Butoxy)Carbonyl Cys(Trt)-OH (Non-Animal Origin)

Boc-Cys(Trt)-NH2(non-animal)

Boc-Cys(Trt)-OH(non-animal)

(2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-tritylsulfanylpropanoicaci

N-Boc-S-Trityl-L-cysteine USP/EP/BP

N-BOC-S-trityl-cysteine

N-tert butyloxycarbonyl-S-triphenylmethyl-L-cysteine

N-Boc-S-trityl-L-cysteine,97%

Nα-(tert-Butoxycarbonyl)-S-(trityl)-L-cysteine

21947-98-8

C6H53CSCH2CHNHCO2CCH33CO2H

C27H29NO4S

Specialty Synthesis

Peptide Synthesis

Cysteine/Cystine

Amino Acid Derivatives

Cysteine [Cys, C]

Boc-Amino Acids and Derivative

Boc-Amino acid series

Amino Acid Derivatives

Amino Acids