8-BROMO-2-METHYL-QUINOLINE
Uses- Product Name
- 8-BROMO-2-METHYL-QUINOLINE
- CAS No.
- 61047-43-6
- Chemical Name
- 8-BROMO-2-METHYL-QUINOLINE
- Synonyms
- 8-Bromoquinaldine;2-Methyl-8-bromoquinoline;8-BROMO-2-METHYL-QUINOLINE;Quinoline, 8-bromo-2-methyl-;8-Bromo-2-methylquinoline >7-Trifluoromethyl-8-hydroxyquinoline;8-BROMO-2-METHYL-QUINOLINE ISO 9001：2015 REACH
- CBNumber
- CB1157974
- Molecular Formula
- C10H8BrN
- Formula Weight
- 222.08
- MOL File
- 61047-43-6.mol
8-BROMO-2-METHYL-QUINOLINE Property
- Melting point:
- 63-65℃
- Boiling point:
- 132°C/0.1mmHg(lit.)
- Density
- 1.488
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 3.17±0.50(Predicted)
- color
- White to Light yellow
- InChI
- InChI=1S/C10H8BrN/c1-7-5-6-8-3-2-4-9(11)10(8)12-7/h2-6H,1H3
- InChIKey
- GQPRZSFQSOEDNV-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC=CC=2Br)C=CC=1C
- CAS DataBase Reference
- 61047-43-6
Safety
- HS Code
- 2933.49.7000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B3444
- Product name
- 8-Bromo-2-methylquinoline
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $75
- Updated
- 2025/07/31
- Product number
- B3444
- Product name
- 8-Bromo-2-methylquinoline
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $226
- Updated
- 2025/07/31
- Product number
- B405250
- Product name
- 8-Bromo-2-methylquinoline
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB168383
- Product name
- 8-Bromo-2-methylquinoline
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 9135AB
- Product name
- 8-Bromo-2-methylquinoline
- Packaging
- 100mg
- Price
- $72
- Updated
- 2021/12/16
8-BROMO-2-METHYL-QUINOLINE Chemical Properties,Usage,Production
Uses
8-Bromo-2-methylquinoline is a quinoline derivative that can be used as a pharmaceutical intermediate.
Synthesis
615-36-1
123-73-9
61047-43-6
To a 6N hydrochloric acid (300 mL) solution of o-bromoaniline (100 g, 0.58 mol) was slowly added trans-2-butenal (81 g, 1.1 mol) at room temperature. The reaction mixture was heated to 100 °C and stirred overnight. Upon completion of the reaction, the mixture was cooled to room temperature, alkalized to pH 8-9 with ammonium hydroxide solution and subsequently extracted with ether (3 × 100 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with petroleum ether/ethyl acetate (12:1 to 10:1, v/v) as eluent to afford 8-bromo-2-methylquinoline as a white solid (59 g, 54% yield). Mass spectrometry (ESI) analysis: calculated value for C10H8BrN was 222.1; measured value was 223 [M + H]+.
References
[1] Patent: WO2010/101949, 2010, A1. Location in patent: Page/Page column 116; 117
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 10, p. 4066 - 4084
[3] Patent: WO2009/80675, 2009, A1. Location in patent: Page/Page column 14
[4] Arkivoc, 2015, vol. 2015, # 3, p. 38 - 51
8-BROMO-2-METHYL-QUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
8-BROMO-2-METHYL-QUINOLINE Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
View Lastest Price from 8-BROMO-2-METHYL-QUINOLINE manufacturers
- Product
- 8-Bromo-2-methylquinoline 61047-43-6
- Price
- US $5.90-3.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-13
- Product
- 8-Bromo-2-methylquinoline 61047-43-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 8-Bromo-2-methylquinoline 61047-43-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08