Voriconazole
- Product Name
- Voriconazole
- CAS No.
- 137234-62-9
- Chemical Name
- Voriconazole
- Synonyms
- Isopropyl 4-hydroxybutane-1-sulfonate;Voriconzole;(2R,3S)-2-(2,4-DIFLUOROPHENYL)-3-(5-FLUOROPYRIMIDIN-4-YL)-1-(1H-1,2,4-TRIAZOL-1-YL)BUTAN-2-OL;2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl)butan-2-ol;(2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol;(2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-((1H)-1,2,4-triazol-1-yl)-butan-2-;(2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-((1H)-1,2,4-triazol-1-yl)-butan-2-ol;UK-10949;UK-109496;Voricozole
- CBNumber
- CB1160110
- Molecular Formula
- C16H14F3N5O
- Formula Weight
- 349.31
- MOL File
- 137234-62-9.mol
Voriconazole Property
- Melting point:
- 127-130°C
- alpha
- D25 -62° (c = 1 in methanol)
- Boiling point:
- 508.6±60.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- Flash point:
- 9℃
- storage temp.
- 2-8°C
- solubility
- DMSO: >20mg/mL
- form
- white powder
- pka
- 11.54±0.29(Predicted)
- color
- White to Almost white
- Merck
- 14,10033
- InChI
- InChI=1/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/s3
- InChIKey
- BCEHBSKCWLPMDN-MGPLVRAMSA-N
- SMILES
- [C@@](C1C=CC(F)=CC=1F)(O)(CN1N=CN=C1)[C@H](C1=NC=NC=C1F)C |&1:0,16,r|
- CAS DataBase Reference
- 137234-62-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,T,F
- Risk Statements
- 22-36/38-52/53-48/22-40-25-61-39/23/24/25-23/24/25-11
- Safety Statements
- 26-36-45-36/37-22-53-16
- RIDADR
- UN1230 - class 3 - PG 2 - Methanol, solution
- WGK Germany
- 3
- RTECS
- UV9145000
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H341Suspected of causing genetic defects
H351Suspected of causing cancer
H361Suspected of damaging fertility or the unborn child
H371May cause damage to organs
H372Causes damage to organs through prolonged or repeated exposure
H373May cause damage to organs through prolonged or repeated exposure
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P273Avoid release to the environment.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- V-032
- Product name
- Voriconazole solution
- Purity
- 2.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
- Packaging
- 1mL
- Price
- $131
- Updated
- 2024/03/01
- Product number
- 32483
- Product name
- Voriconazole
- Purity
- VETRANAL
- Packaging
- 25mg
- Price
- $145
- Updated
- 2024/03/01
- Product number
- 1718008
- Product name
- Voriconazole
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 100mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- V0116
- Product name
- Voriconazole
- Purity
- >98.0%(HPLC)
- Packaging
- 100mg
- Price
- $27
- Updated
- 2024/03/01
- Product number
- V0116
- Product name
- Voriconazole
- Purity
- >98.0%(HPLC)
- Packaging
- 1g
- Price
- $151
- Updated
- 2024/03/01
Voriconazole Chemical Properties,Usage,Production
Description
Voriconazole is a broad-spectrum triazole antifungal ,it is primarily used for the treatment of progressive, possibly life-threatening infections in immune deficiency patients. Indications include: immunosuppressed patients with severe fungal infections, acute invasive aspergillosis (the most common pathogen is Aspergillus fumigatus, followed by A. flavus, Aspergillus niger and Aspergillus soil), severe invasive infections caused by fluconazole-resistant Candida (including C. krusei) severe infection caused by Foot actinomycetes bacteria genus and Fusarium bacteria genus . Moderate to severe renal insufficiency is administered intravenously paying caution.
Chemical Properties
Cyrstalline Solid
Originator
Pfizer (UK)
Uses
Voriconazole is an antifungal (systemic) that belong to an ergosterol biosynthesis inhibitor. It is used to treat serious fungal or yeast infections, such as aspergillosis (fungal infection in the lungs), candidemia (fungal infection in the blood), esophageal candidiasis (candida esophagitis), or other fungal infections (infections in the skin, stomach, kidney, bladder, or wounds).
Indications
Voriconazole (Vfend), a derivative of fluconazole, is a second-generation triazole that has improved antifungal activity against Aspergillus and Fusarium spp., P. boydii, Penicillium marneffei, and fluconazole-resistant Candida spp. Like fluconazole, voriconazole has high oral bioavailability and good cerebrospinal fluid penetration, but unlike fluconazole, it undergoes extensive hepatic metabolism and is highly protein bound. No significant amount of bioactive drug is excreted into the urine. Dosage reduction is necessary with severe hepatic insufficiency but not with renal insufficiency.
Definition
ChEBI: Voriconazole is a triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. It is an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4. It has a role as a P450 inhibitor. It is a member of pyrimidines, a difluorobenzene, a tertiary alcohol, a triazole antifungal drug and a conazole antifungal drug.
brand name
Vfend (Pfizer).
Antimicrobial activity
The spectrum includes most fungi that cause human disease: dimorphic fungi (Blast. dermatitidis, Coccidioides spp., Hist. capsulatum, Paracocc. brasiliensis, Pen. marneffei and Spor. schenckii), molds (Aspergillus spp., Fusarium spp. and Scedosporium spp.), dematiaceous fungi and yeasts (Candida spp., Cryptococcus spp. and Trichosporon spp.).
Acquired resistance
Some fluconazole- and itraconazole-resistant strains of Candida and Aspergillus spp. show reduced susceptibility to voriconazole.
General Description
Voriconazole is a synthetically prepared, broad-spectrum triazole derivative of fluconazole, which shows in vitro activity against many yeasts and a broad-spectrum of mold and dermatophyte isolates. Its mode of action involves the inhibition of cytochrome P450 (CYP)-dependent enzyme, 14-α-sterol demethylase, and hence it is involved in disrupting the cell membrane and terminate the fungal growth.
Pharmaceutical Applications
Voriconazole is a triazole, antifungal agent that inhibits a broad range of pathogenic yeasts, including Candida (MIC = 0.03-8 μg/ml), and filamentous fungi such as Aspergillus, Scedosporium, and Fusarium. Its inhibitory action results from its ability to inhibit the synthesis of ergosterol, the major sterol of the fungal cell membrane.
Biological Activity
Voriconazole is an triazole antifungal agent used to treat serious fungal infections. It inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-α sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes. Displays potent activity against Candida , Cryptococcus and Aspergillus species.
Pharmacokinetics
Oral absorption: 96%
Cmax 400 mg oral: c. 2 mg/L after 2 h
Plasma half-life: c. 6 h
Volume of distribution: 4.6 L/kg
Plasma protein binding: 58%
Absorption
Oral absorption is rapid and almost complete, and is unaffected by intragastric pH. In adults, there is a disproportionate increase in blood concentrations with increasing oral and parenteral dosage, due to partial saturation of first-pass metabolism. In children given low dosages of the drug, proportional changes in drug levels are seen.
Distribution
It is widely distributed into body tissues and fluids, including brain and CSF.
Metabolism and excretion
It is extensively metabolized by the liver. More than 80% of a dose appears in the urine, but less than 2% is excreted in unchanged form. It is metabolized by several different hepatic cytochrome P450 enzymes. Some people with point mutations in the genes encoding these enzymes are poor metabolizers while others are extensive metabolizers. Drug levels are as much as four-fold lower in individuals who metabolize the drug more extensively.
Clinical Use
Acute and chronic invasive aspergillosis
Serious invasive Candida infections
Serious infections caused by Scedosporium and Fusarium spp.
Side effects
Unwanted effects include mild to moderate visual disturbance, rashes, and transient abnormalities of liver enzymes. Rare side effects include life-threatening hepatitis.
Synthesis
The synthesis of
voriconazole is an excellent example of process research. As
depicted in the scheme, 5-fluorouracil (229) was chlorinated
in both the 2- and 4- positions using a mixture of
phosphorus oxychloride and N,N-dimethylaniline at 95?? C to
afford 230 in 95% yield. Dichloro pyrimidine 230 was
reacted with ethyl magnesium bromide to give
dihydropyrimidine adduct 231. Adduct 231 was oxidized
prior to quenching using a mixture of iodine and TEA in
THF to give 2,4-dichloro-6-ethyl-5-fluoro pyrimidine (232)
in 75% yield. Reaction of 232 with two equiv of aqueous
NaOH at reflux gave selective displacement of the chloro
functionality at 4-position. Acidification of the reaction and
extraction with DCM gave 2-chloro-6-ethyl-5-fluoro-4(3H)-
pyrimidine which was conveniently isolated as its ammonia
salt 233. Dechlorination of 233 was achieved using catalytic
hydrogenation at 50?? to provide 234 in 80% yield.
Alternatively, 4-fluoro-6-ethyl-5-fluoropyrimidine (234) was
prepared in a two-pot process in which methyl 3-
oxopentanoate (235) was fluorinated with fluorine gas to
give methyl 2-fluoro-3-oxopentanoate (236) in 80-90% yield. This ester was then cyclized with formamidine
acetate in the presence of NaOMe to give 234 in a moderate
yield (50-70%). Reaction of 234 with phosphorus
oxychloride and TEA afforded 4-chloro-6-methyl-5-
fluoropyrimidine (237) in 90% yield. Reaction of 237 with
NBS in the presence of AIBN initiator provided bromide
238 in 95% yield. A Reformatsky protocol was employed in
the condensation of 238 with ketone 239 which was an
intermediate in the commercial synthesis of Diflucan. A
solution of iodine in THF was added to a slurry of zinc and
lead at rt and then a mixture of bromide 238 and ketone 239
were added to the above mixture at 5??C for 30 min. This
provided the best diastereomeric selectivity and the ratio of
241 and 240 enantiomeric pair reached approximately 10 to
1. Adduct 241 was de-chlorinated using standard
hydrogenation condition (5% w/w Pd on carbon /15 psi hydrogen) to give the racemate of voriconazole. The racemic
voriconazole was resolved using (1R)-10-camphorsulfonic
acid (242) and crystallization of the required diastereomeric
salt provided optically pure voriconazole (28) in 80% yield.
Veterinary Drugs and Treatments
Voriconazole may be a useful treatment for a variety of fungal infections in veterinary patients, particularly against Blastomyces, Cryptococcus, and Aspergillus. It has high oral bioavailability in a variety of species and can cross into the CNS. Currently available human dosage forms are extremely expensive, however, and little clinical experience has occurred using voriconazole in veterinary patients. There is considerable interest in using voriconazole for treating aspergillosis in pet birds as their relative small size may allow the drug to be affordable; additional research must be performed before dosing regimens are available.
Drug interactions
Potentially hazardous interactions with other drugs
Analgesics: concentration of diclofenac, ibuprofen,
alfentanil, methadone and oxycodone increased,
consider reducing alfentanil and methadone dose;
concentration of fentanyl possibly increased.
Anti-arrhythmics: avoid with dronedarone.
Antibacterials: concentration reduced by rifabutin;
increase dose of voriconazole from 200 to 350 mg
and from 100 to 200 mg (depends on patient’s
weight), and increase IV dose to 5 mg/kg if used in
combination - avoid concomitant use if possible;
increased rifabutin levels - monitor for toxicity;
concentration reduced by rifampicin - avoid.
Anticoagulants: avoid with apixiban and rivaroxaban;
enhanced effect of coumarins.
Antidepressants: avoid concomitant use with
reboxetine; concentration reduced by St John’s wort
- avoid.
Antidiabetics: possibly increased concentration of
sulphonylureas.
Antiepileptics: concentration possibly reduced
by carbamazepine, phenobarbital and primidone
- avoid; fosphenytoin and phenytoin reduces
voriconazole concentration and voriconazole
increases fosphenytoin and phenytoin concentration
- double oral voriconazole dose and increase IV to 5
mg/kg dose if using with phenytoin; avoid if possible.
Antimalarials: avoid concomitant use with
artemether/lumefantrine and piperaquine with
artenimol.
Antipsychotics: concentration of lurasidone
increased - avoid concomitant use; increased risk
of ventricular arrhythmias with pimozide - avoid
concomitant use; possibly increased quetiapine levels
- avoid concomitant use.
Antivirals: concentration increased or decreased by
atazanavir and concentration of atazanavir reduced;
concentration of daclatasvir possibly increased -
reduce daclatasvir dose; concentration possibly
affected by darunavir; concentration reduced by
efavirenz and ritonavir; also concentration of
efavirenz increased - avoid with ritonavir; with
efavirenz reduce dose by 50
% and increase dose of
voriconazole to 400 mg twice daily; concentration
possibly increased by simeprevir - avoid;
concentration possibly affected by telaprevir -
increased risk of ventricular arrhythmias; possibly
increased saquinavir levels; concentration of
simeprevir possibly increased - avoid.
Avanafil: possibly increased avanafil concentration -
avoid.
Benzodiazepines: may inhibit metabolism of
diazepam and midazolam.
Ciclosporin: AUC increased - reduce ciclosporin
dose by 50
% and monitor closely.
Clopidogrel: possibly reduced antiplatelet effect.
Cytotoxics: possibly increases bosutinib
concentration - avoid or reduce dose of bosutinib;
possibly increases crizotinib and everolimus
concentration - avoid; possibly increases ibrutinib,
pazopanib and ponatinib concentration - reduce
dose of ibrutinib, pazopanib and ponatinib; avoid
with ceritinib, lapatinib, nilotinib, cabazitaxel and
docetaxel (or reduce dose of cabazitaxel, ceritinib
and docetaxel); reduce dose of panobinostat and
ruxolitinib.
Domperidone: possible increased risk of arrhythmias
- avoid.
Ergot alkaloids: risk of ergotism - avoid.
Ivacaftor and lumacaftor: possibly increase ivacaftor
concentration - reduce dose of ivacaftor and ivacaftor
with lumacaftor.
Lipid-lowering drugs: possibly increased risk of
myopathy with atorvastatin or simvastatin; avoid
with lomitapide.
Ranolazine: possibly increased ranolazine
concentration - avoid.
Retinoids: possibly increased risk of tretinoin
toxicity.
Sirolimus: increased sirolimus concentration - avoid.
Tacrolimus: AUC increased - reduce tacrolimus
dose to a third and monitor closely.
Ulcer-healing drugs: esomeprazole and omeprazole
concentration increased - reduce omeprazole dose
by 50
%.
Metabolism
Voriconazole is metabolised by hepatic cytochrome P450
isoenzyme CYP2C19; the major metabolite is the inactive
N-oxide. Metabolism via isoenzymes CYP2C9 and
CYP3A4 has also been shown in vitro.
Voriconazole is eliminated via hepatic metabolism with
less than 2
% of the dose excreted unchanged in the urine.
After administration of a radiolabelled dose of
voriconazole, approximately 80
% of the radioactivity
is recovered in the urine as metabolites. The majority
(>94
%) of the total radioactivity is excreted in the first 96
hours after both oral and intravenous dosing
storage
Store at +4°C
Mode of action
Voriconazole is structurally related to fluconazole (Pfizer, diflucan) and acts by inhibiting the cytochrome P450- dependant enzyme 14a-sterol demethylase of ergosterol synthesis (thereby resulting in the formation of a cell membrane with abnormal characteristics and accumulation of toxic sterol intermediates). Voriconazole was more active than itraconazole and fluconazole against Cryptococcus neoformans and a variety of Candidas species such as C. albicans, C. glabrata C. krusei. It also exhibits similar or superior activity compared to amphotericin B and itraconazole against filamentous fungi such as Aspergillus, an important pathogen which is not susceptible to fluconazole.
Precautions
Significant drug interactions include cyclosporins(increased cyclosporine levels), phenytoin, rifampin,and rifabutin (decreased voriconazole levels). Becauseof its low toxicity profile, this drug may gain importancein the chronic treatment of infections with invasive dimorphicfungi and resistant Candida spp.
References
[1] sabo ja, abdel-rahman sm. voriconazole: a new triazole antifungal. ann pharmacother. 2000 sep;34(9):1032-43.
[2] johnson lb, kauffman ca. voriconazole: a new triazole antifungal agent. clin infect dis. 2003 mar 1;36(5):630-7.
Voriconazole Preparation Products And Raw materials
Raw materials
Preparation Products
Voriconazole Suppliers
- Tel
- 010-010-010-62971590 18548936886
- Fax
- 010-62340519
- jack@oka-vip.com
- Country
- China
- ProdList
- 6897
- Advantage
- 58
- Tel
- 0531-69959492 15966603228
- Fax
- 0531-69959492
- 85633700@qq.com
- Country
- China
- ProdList
- 80
- Advantage
- 55
- Tel
- 010-83386559 18810831598
- Fax
- 010-83386758
- sales@lianben.com
- Country
- China
- ProdList
- 93
- Advantage
- 58
- Tel
- 0531-69959492 18560053868
- Fax
- 0531-88603458
- 85349064@qq.com
- Country
- China
- ProdList
- 154
- Advantage
- 58
- Tel
- 13983114937
- Qiyuanhong_rich@163.com
- Country
- China
- ProdList
- 36
- Advantage
- 58
- Tel
- 021-50182298 021-50180596
- Fax
- +86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2208
- Advantage
- 55
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-61259108 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15839
- Advantage
- 69
- Tel
- +86-21-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6005
- Advantage
- 61
- Tel
- +86 351 7031519
- Fax
- +86 351 7031519
- sales@RHFChem.com
- Country
- China
- ProdList
- 2338
- Advantage
- 56
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 010-89508211 18501085097
- Fax
- 010-89508210
- sales.bj@hwrkchemical.com
- Country
- China
- ProdList
- 8415
- Advantage
- 55
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44689
- Advantage
- 61
- Tel
- 010-81769521,89753524,81760121 15901403431
- Fax
- +86-10-81769652
- sales01@mediking.cn
- Country
- China
- ProdList
- 704
- Advantage
- 68
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- sales@capotchem.com
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9414
- Advantage
- 66
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9809
- Advantage
- 59
- Tel
- 86-10-64911848-8020.8010
- Fax
- 86-10-64946614
- sales@lunarsun.com.cn
- Country
- China
- ProdList
- 95
- Advantage
- 60
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42958
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 15527768850
- 1791901229@qq.com
- Country
- China
- ProdList
- 8843
- Advantage
- 52
- Tel
- 027-59207852 13308628970
- Fax
- QQ3130921841
- buy@fortunachem.com
- Country
- China
- ProdList
- 2876
- Advantage
- 58
- Tel
- 0755-83725681-603
- Fax
- +86 755 28094224
- Country
- China
- ProdList
- 4496
- Advantage
- 50
- Tel
- 010-56205725
- Fax
- 010-65763397
- waley188@sohu.com
- Country
- China
- ProdList
- 12335
- Advantage
- 58
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 22514
- Advantage
- 55
- Tel
- 400-400-6206333 18521732826
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 021-61552785
- Fax
- 021-55660885
- sales@shshiji.com
- Country
- China
- ProdList
- 9545
- Advantage
- 55
- Tel
- 15902102743
- Fax
- 0731-57805668
- shelley@furuipharma.com
- Country
- China
- ProdList
- 452
- Advantage
- 55
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4428
- Advantage
- 55
- Tel
- +86-10-83386766
- Fax
- +86-10-83386758
- sales@lianben.com
- Country
- China
- ProdList
- 91
- Advantage
- 58
- Tel
- 025-57798810
- Fax
- 025-57019371
- sales@sunlidabio.com
- Country
- China
- ProdList
- 3239
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7783
- Advantage
- 58
- Tel
- 180000000
- 3755454181@qq.com
- Country
- China
- ProdList
- 420
- Advantage
- 55
- Tel
- 025-84683399 13952017251
- Fax
- 025-84683112
- sales@sinfachem.com
- Country
- China
- ProdList
- 217
- Advantage
- 56
- Tel
- 27-81302488 18007166089
- Fax
- 027-81302088
- info@dkybpc.com
- Country
- China
- ProdList
- 2024
- Advantage
- 58
- Tel
- 13971561712, 13995564702, 027-50664929
- Fax
- 027-50664927
- hbeixys2001@163.com
- Country
- China
- ProdList
- 3120
- Advantage
- 55
- Tel
- +86 (21) 5471-7132
- Fax
- +86 (21) 5471-6993
- Country
- China
- ProdList
- 344
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41462
- Advantage
- 60
- Tel
- 021-54359730 400-008-9730
- Fax
- 021-54353864
- info@chemxyz.com
- Country
- China
- ProdList
- 3991
- Advantage
- 60
- Tel
- 023-89130144 18523560356
- Fax
- 023-67534737
- zhyong1011@163.com
- Country
- China
- ProdList
- 299
- Advantage
- 58
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18043
- Advantage
- 56
- Tel
- 028-81700200 18116577057
- Fax
- 028-81705658
- 3003855609@qq.com
- Country
- China
- ProdList
- 7887
- Advantage
- 56
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9649
- Advantage
- 58
- Tel
- 400-8592883 15367835770
- Fax
- 0731-82251112
- viola@huatengsci.com
- Country
- China
- ProdList
- 5875
- Advantage
- 58
- Tel
- 0512-87182056 18013166090
- Fax
- 0512-87182056
- lingling.qi@yacoo.com.cn
- Country
- China
- ProdList
- 7295
- Advantage
- 60
- Tel
- 86-574-27787657
- Fax
- 86-574-27912196
- info@dearchem.com
- Country
- China
- ProdList
- 4613
- Advantage
- 58
- Tel
- 027-59262863 13277907145 3091977954
- Fax
- 027-59420980
- Country
- China
- ProdList
- 4943
- Advantage
- 58
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10276
- Advantage
- 55
View Lastest Price from Voriconazole manufacturers
- Product
- Voriconazole 137234-62-9
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 50kg/Month
- Release date
- 2024-10-11
- Product
- Voriconazole 137234-62-9
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 98.5%min
- Supply Ability
- 100kg
- Release date
- 2021-06-02
- Product
- Voriconazole 137234-62-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- USP, BP, EP
- Supply Ability
- 5,000KG
- Release date
- 2024-05-17