3-(4-Chlorophenyl)propan-1-ol

Product Name: 3-(4-Chlorophenyl)propan-1-ol
CAS No.: 6282-88-8
Chemical Name: 3-(4-Chlorophenyl)propan-1-ol
Synonyms: Pitolisant Impurity 9;4-Chlorobenzenepropanol;Benzenepropanol, 4-chloro-;3-(4-CHLOROPHENYL)PROPANOL;3-(4'-CHLOROPHENYL)PROPANOL;3-(4-Chlorophenyl)propanol95%;3-(4-CHLOROPHENYL)PROPAN-1-OL;3-(4-Chlorophenyl)propanol 95%;2-(1-oxoheptyl)indene-1,3-dione;3-(4-CHLOROPHENYL)PROPAN-1-OL 98%
CBNumber: CB1168752
Molecular Formula: C9H11ClO
Formula Weight: 170.64
MOL File: 6282-88-8.mol

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3-(4-Chlorophenyl)propan-1-ol Property

Boiling point:: 104°C 0,1mm
Density: 1.151±0.06 g/cm3(Predicted)
refractive index: 1.54
storage temp.: Sealed in dry,Room Temperature
form: clear liquid
pka: 15.03±0.10(Predicted)
color: Colorless to Yellow
InChI: InChI=1S/C9H11ClO/c10-9-5-3-8(4-6-9)2-1-7-11/h3-6,11H,1-2,7H2
InChIKey: ZHBIWFGGIKFSHZ-UHFFFAOYSA-N
SMILES: C1(CCCO)=CC=C(Cl)C=C1
CAS DataBase Reference: 6282-88-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-41
Safety Statements: 26-36/37/39-24/25-39
HazardClass: IRRITANT
HS Code: 2906290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS003137
Product name: 3-(4-Chlorophenyl)-1-propanol
Purity: AldrichCPR
Packaging: 500MG
Price: $70.9
Updated: 2024/03/01

TCI Chemical

Product number: C3527
Product name: 3-(4-Chlorophenyl)propan-1-ol
Purity: >98.0%(GC)
Packaging: 1g
Price: $29
Updated: 2025/07/31

TCI Chemical

Product number: C3527
Product name: 3-(4-Chlorophenyl)propan-1-ol
Purity: >98.0%(GC)
Packaging: 5g
Price: $114
Updated: 2025/07/31

TRC

Product number: C596505
Product name: 3-(4-Chlorophenyl)propan-1-ol
Packaging: 1g
Price: $40
Updated: 2021/12/16

TRC

Product number: C596505
Product name: 3-(4-Chlorophenyl)propan-1-ol
Packaging: 5g
Price: $110
Updated: 2021/12/16

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3-(4-Chlorophenyl)propan-1-ol Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid.

Uses

3-(4-Chlorophenyl)propan-1-ol is used in preparation of 2-Oxo-2H-chromene-3-carboxylic Acid Amide derivatives as Aldo-Keto reductase inhibitors.

Definition

ChEBI: 3-(4-Chlorophenyl)propan-1-ol is an organochlorine compound.

Synthesis

1615-02-7

6282-88-8

General procedure for the synthesis of 3-(4-chlorophenyl)propan-1-ol from p-chlorocinnamic acid: yield range 23.3-88.0%. As an example, 3-(4-chlorophenyl)propan-1-ol (3c) was synthesized as follows: under nitrogen protection and an ice bath, a THF solution of 3-(4-chlorophenyl)acrylic acid (2c, 2.74 g, 15 mmol) was slowly added to a tetrahydrofuran (THF, 30 mL) suspension of lithium aluminium hydride (1.71 g, 45 mmol), and the addition process was controlled to be completed within 30 min. The addition process was controlled to be completed within 30 min. The reaction mixture was stirred to room temperature and then continued to reflux for 4 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the complete consumption of the raw materials, the reaction mixture was cooled to room temperature. Subsequently, methanol (15 mL) and water (15 mL) were added slowly and dropwise to quench the reaction and the pH was adjusted with 10% hydrochloric acid solution to 3. The crude product was extracted with ethyl acetate (3 x 30 mL), the organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure. The resulting yellow oil was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate=4:1, v/v) to give a yellow oily target product in 54.7% yield. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 7.27-7.22 (m, 2H), 7.15-7.10 (m, 2H), 3.66 (t, J=6.4 Hz, 2H), 2.68 (t, J=7.44 Hz, 2H), 1.91-1.81 (m, 2H).

References

[1] Chinese Chemical Letters, 2016, vol. 27, # 4, p. 555 - 558
[2] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 7, p. 1849 - 1853
[3] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 18, p. 4752 - 4756

3-(4-Chlorophenyl)propan-1-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(4-Chlorophenyl)propan-1-ol Suppliers

Americas 1 Belgium 1 China 131 Europe 1 Germany 3 India 10 Japan 1 United Kingdom 6 United States 16 Global 170

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View Lastest Price from 3-(4-Chlorophenyl)propan-1-ol manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-(4-Chlorophenyl)propan-1-ol 6282-88-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 3-(4-Chlorophenyl)propan-1-ol 6282-88-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: KG/T
Release date: 2019-12-18

6282-88-8, 3-(4-Chlorophenyl)propan-1-olRelated Search:

CHLORPROPAMIDE Triphenylmethyl Chloride Chlorodimethylphenylsilane tert-Butylchlorodiphenylsilane 1,2-Dichloro-4-(chloromethyl)benzene CHLOROPHENYLSILANE CHLOROPROPANOL, MIXED ISOMERS Epichlorohydrin rubber Propargyl alcohol 3,3,3-Tris(4-chlorophenyl)propionic acid COUMACHLOR 3-(4-Chlorophenyl)propanoic acid D-4-Chlorophenylalanine DL-4-Chlorophenylalanine methyl ester hydrochloride DL-4-CHLOROPHENYLALANINE ETHYL ESTER HYDROCHLORIDE Baclofen BOC-D-4-Chlorophe CHLORFENPROP-METHYL

3-(4-CHLOROPHENYL)PROPAN-1-OL

3-(4'-CHLOROPHENYL)PROPANOL

3-(4-CHLOROPHENYL)PROPANOL

3-(4-Chlorophenyl)propan-1-ol, 95+%

3-(4-Chlorophenyl)propanol 95%

2-(1-oxoheptyl)indene-1,3-dione

3-(4-Chlorophenyl)propanol95%

Benzenepropanol, 4-chloro-

4-Chlorobenzenepropanol

Pitolisant Impurity 9

3-(4-CHLOROPHENYL)PROPAN-1-OL 98%

6282-88-8

6288-88-8

C9H11O2

Phenyls & Phenyl-Het