DIETHYL ISOCYANOMETHYLPHOSPHONATE Property

Boiling point:

84-87 °C0.1 mm Hg(lit.)

Density 

1.105 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.433(lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

form 

Liquid

color 

Clear colorless to yellow

BRN 

4674920

CAS DataBase Reference

41003-94-5

Safety

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

26-36

WGK Germany 

3

F 

8-9

HS Code 

29319090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

DIETHYL ISOCYANOMETHYLPHOSPHONATE Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to yellow liquid

Uses

Reactant for:

• Copper-catalyzed cycloaddition reactions
• Preparation of orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase
• Synthesis of sterol analogs as antifungal agents against plant pathogens
• Asymmetric synthesis of steroidal 2,5-diketopiperazines prepared via isocyanide chemistry based on stereoselective Ugi four component condensation and subsequent cyclocondensation reactions
• The Passerini reaction