Description References
ChemicalBook > CAS DataBase List > D-Mannose

D-Mannose

Description References
Product Name
D-Mannose
CAS No.
3458-28-4
Chemical Name
D-Mannose
Synonyms
Aldohexos;D-MANNOPYRANOSE;D-MANOSE;D-MAN;CARUBINOSE;D-MannMtol;α-D-mannose;d-[1,2,3-13C3]Mannose;DL-allo-2,3,4,5,6-Pentahydroxy-hexanal;SEMINOSE
CBNumber
CB1175305
Molecular Formula
C6H12O6
Formula Weight
180.16
MOL File
3458-28-4.mol
More
Less

D-Mannose Property

Melting point:
133-140 °C(lit.)
alpha 
14 º (589nm, c=10, H2O)
Boiling point:
232.96°C (rough estimate)
Density 
1,539 g/cm3
refractive index 
1.5730 (estimate)
storage temp. 
room temp
solubility 
H2O: 50 mg/mL
form 
powder
pka
12.08(at 25℃)
color 
White
optical activity
[α]20/D +13.8±0.5°, 24 hr, c = 10% in H2O
Water Solubility 
2480 g/L (17 ºC)
λmax
λ: 260 nm Amax: 0.1
λ: 280 nm Amax: 0.1
Sensitive 
Hygroscopic
Merck 
14,5747
BRN 
1564373
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
WQZGKKKJIJFFOK-ATJJXCEKSA-N
LogP
-2.71 at 25℃
CAS DataBase Reference
3458-28-4(CAS DataBase Reference)
NIST Chemistry Reference
D-Mannose(3458-28-4)
EPA Substance Registry System
D-Mannose (3458-28-4)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
3
F 
3
TSCA 
Yes
HS Code 
29400010
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
63580
Product name
D-(+)-Mannose
Purity
for microbiology, ≥99%
Packaging
25g
Price
$70.8
Updated
2024/03/01
Sigma-Aldrich
Product number
63579
Product name
D-(+)-Mannose
Purity
BioUltra, ≥99.5% (sum of enantiomers, HPLC)
Packaging
10g
Price
$181
Updated
2024/03/01
TCI Chemical
Product number
M0045
Product name
D-(+)-Mannose
Packaging
25G
Price
$34
Updated
2024/03/01
TCI Chemical
Product number
M0045
Product name
D-(+)-Mannose
Packaging
100G
Price
$89
Updated
2024/03/01
Alfa Aesar
Product number
A10842
Product name
D-(+)-Mannose, 99%
Packaging
25g
Price
$47
Updated
2024/03/01
More
Less

D-Mannose Chemical Properties,Usage,Production

Description

D-Mannose is a nutritional supplement that can be found in cranberries, peaches, apples, other berries, and some plants. D-mannose is a sugar that has an important role in human metabolism, especially in the glycosylation of certain proteins. D-mannose functionalizes by the inhibition of bacterial adherence to uroepithelial cells.
More than 90 percent of recurrent urinary tract infections (UTIs) are caused by Escherichia coli (E. coli), which is normally found in the intestinal tract. The cell walls of each E. coli are covered with tiny fingerlike projections called fimbria. Mannose can bind to the lectin on the bacteria’s fimbria so that the bacteria can be effectively rinsed out by urination.
D-Mannose is by far the most effective supplement for both treatment and prevention of UTIs. And it is used for the treating carbohydrate-deficient glycoprotein syndrome, an inherited metabolic disorder.

References

[1] http://www.webmd.com
[2] Bojana Kranjcˇec, Dino Papesˇ , Silvio Altarac (2013) D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial, World J Urol, 32, 79-84

Chemical Properties

White crystalline powder

Uses

It has been used in a study to assess the synthesis of a family of amphiphilic glycopolymers. It has also been used in a study to investigate the early detection of bronchiolitis obliterans after lung transplantation.

Uses

D-mannose acts as an alternative energy source utilized by brain. It is used in the study of assessing the synthesis of amphiphilic glycopolymers and investigating early detection of bronchiolitis obliterans.It may be useful in the treatment of urinary tract infections (UTIs) and carbohydrate-deficient glycoprotein syndrome type 1b. It is also useful in the formation of glycan structure and glycosylation.

Uses

D-Mannose is a carbohydrate that is important in the glycosylation of molecules in a variety of cellular processes. It is involved in N and O glycosylation of bovine why protein products, used in inf ant formulas. It is also responsible for the O-glycosylation of the T helper cell-derived cytokine interlukin-17A, an important cell-signaling molecule.

Application

D-mannose is a simple sugar structurally related to glucose. It is absorbed slowly from the gastrointestinal tract, and then a large proportion of it is excreted into the urine.
D-(+)-Mannose has been used:
as a reference standard in monosaccharide analysis and quantification from sea squirts Ascidiella aspersa
as a medium component for the selection of P898012 sorgum seeds transfected with Agrobacterium
in segmented filamentous bacterium (SFB) medium supplement for culturing human cell lines
Mannose is an aldohexose carbohydrate. It is isomer of glucose with varying C2 position configuration. Majority of mannose is synthesised from its epimer glucose. It is part of the glycans present in endoplasmic reticulum (ER)/Golgi.

Definition

ChEBI: D-Mannopyranose having alpha-configuration at the anomeric centre.

General Description

Mannose is a monosaccharide.

Flammability and Explosibility

Not classified

Biochem/physiol Actions

Mannose, a six-carbon carbohydrate, is the C-2 epimer of glucose and a critical sugar for protein glycosylation. Mannose can also be utilized by the brain as an alternative energy source.

Side effects

D-mannose appears to be generally well tolerated in people. You should be cautious about using D-mannose if you are pregnant or breastfeeding, because there has not been enough study on its safety in these circumstances. Side effects of D-mannose may include: bloating and loose stools. D-mannose supplements should be used with caution if you have diabetes. It may make it harder to control your blood sugar. High doses of D-mannose may cause kidney damage.

Source

D-mannose is a sugar that can be found in some fruits and vegetables, such as oranges, apples, peaches, broccoli and green beans. It has been used in the past to treat UTIs in animals. Now, there is some interest into whether it could also treat and prevent UTI in humans.
D-mannose is a naturally occurring simple sugar that your body utilizes to help cleanse the urinary tract and maintain a healthy bladder lining. It’s metabolized only in small amounts, with excess amounts rapidly excreted in urine, so it won’t interfere with healthy blood sugar regulation. Clinical studies have demonstrated that, when taken regularly, D-mannose promotes normal urinary tract function by cleansing and maintaining the health of the bladder lining.

Purification Methods

Crystallise -D(+)-mannose repeatedly from EtOH, aqueous 80% EtOH, AcOH or MeOH/propan-2-ol and then dry it in vacuo over P2O5 at 60o. [For 1H NMR and equilibr

D-Mannose Preparation Products And Raw materials

Raw materials

D-Mannitol

Preparation Products

More
Less

D-Mannose Suppliers

Americas 1 Belgium 1 Canada 2 China 517 Czech 1 Europe 4 France 3 Germany 12 India 19 Italy 1 Japan 5 Slovakia 1 Switzerland 5 United Kingdom 18 United States 73 USA 1 Global 664
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
ALB Technology Limited
Tel
702-983-3769
Fax
702-983-3769
Email
sales@albtechnology.com
Country
United States
ProdList
2993
Advantage
55
Alfa Chemistry
Tel
1-516-6625404
Fax
1-516-927-0118
Email
support@alfa-chemistry.com
Country
United States
ProdList
9171
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
Alfa Chemistry
Tel
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
24072
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Wilshire Chemical Company Inc.
Tel
--
Fax
--
Email
WilshrChem@AOL.COM
Country
United States
ProdList
3498
Advantage
58
CarboMer, Inc.
Tel
--
Fax
--
Email
sales@carbomer.com
Country
United States
ProdList
4026
Advantage
67
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
H. Interdonati, Inc.
Tel
--
Fax
--
Email
flavorplus@hinterdonati.com
Country
United States
ProdList
261
Advantage
58
ECSA Chemicals
Tel
--
Fax
--
Email
marketing@ecsa.ch
Country
United States
ProdList
1735
Advantage
58
Fleurchem, Inc.
Tel
--
Fax
--
Email
info@fleurchem.com
Country
United States
ProdList
790
Advantage
58
Charkit Chemical Corporation
Tel
--
Fax
--
Email
sales@charkit.com
Country
United States
ProdList
2993
Advantage
65
Qingdao Free Trade Zone United International Co Ltd
Tel
--
Fax
--
Email
info@unitedint.com
Country
United States
ProdList
604
Advantage
58
Glentham Life Sciences Ltd
Tel
--
Fax
--
Email
info@glentham.com
Country
United States
ProdList
2026
Advantage
58
Penta International Corporation
Tel
--
Fax
--
Email
lisaa@pentamfg.com
Country
United States
ProdList
5042
Advantage
58
Jiangyin Healthway International Trade Co., Ltd
Tel
--
Fax
--
Email
info@healthwaychem.com
Country
United States
ProdList
1006
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Genabolix Laboratory, Inc.
Tel
--
Fax
--
Email
info@genabolix.com
Country
United States
ProdList
51
Advantage
0
Omicron Biochemicals, Inc.
Tel
--
Fax
--
Email
omicron@omicronbio.com
Country
United States
ProdList
580
Advantage
64
AppliChem, LLC
Tel
--
Fax
--
Email
sales@applichem.com
Country
United States
ProdList
169
Advantage
50
Chiralblock Bioscience LLC
Tel
--
Fax
--
Email
info@chiralblock.com
Country
United States
ProdList
144
Advantage
0
Sisco Research Laboratories Pvt. Ltd.
Tel
--
Fax
--
Email
srlmarketing@dishnetdsl.net
Country
United States
ProdList
1905
Advantage
64
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Cambridge Isotope Laboratories, Inc.
Tel
--
Fax
--
Email
cilsales@isotope.com
Country
United States
ProdList
6598
Advantage
79
ChemService Inc.
Tel
--
Fax
--
Country
United States
ProdList
6379
Advantage
68
Medical Isotopes
Tel
--
Fax
--
Email
stohler@medicalisotopes.com
Country
United States
ProdList
6181
Advantage
68
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
INDOFINE Chemical Company, Inc.
Tel
--
Fax
--
Email
chemical@indofinechemical.com
Country
United States
ProdList
6176
Advantage
69
Naugra Export
Tel
--
Fax
--
Country
United States
ProdList
1332
Advantage
47
PhytoTechnology Laboratories
Tel
--
Fax
--
Email
cs@phytotechlab.com
Country
United States
ProdList
143
Advantage
71
Sciencelab.com, Inc.
Tel
--
Fax
--
Email
accounting@sciencelab.com
Country
United States
ProdList
4159
Advantage
82
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
City Chemical LLC
Tel
--
Fax
--
Email
sales@citychemical.com
Country
United States
ProdList
6708
Advantage
72
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
NILE CHEMICALS
Tel
--
Fax
--
Email
nilechem@vsnl.net
Country
United States
ProdList
1369
Advantage
61
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
More
Less

View Lastest Price from D-Mannose manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
D-Mannose 3458-28-4
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-30
WUHAN FORTUNA CHEMICAL CO., LTD
Product
D-Mannose 3458-28-4
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
1000KGS
Release date
2021-07-15
Hengshui Haoye Co.,Ltd.
Product
D-Mannose 3458-28-4
Price
US $0.00/Kg/Bag
Min. Order
500Kg/Bag
Purity
99%
Supply Ability
10 tons
Release date
2021-07-15

3458-28-4, D-MannoseRelated Search:

D-Mannose D-mannose 6-phosphate monosodium,SODIUM MANNOSE PHOSPHATE D-MANNONO-1,4-LACTONE TATM METHYL-ALPHA-D-MANNOPYRANOSIDE Calcium Alginate D-MANNOSE 6-PHOSPHATE BARIUM,D-MANNOSE 6-PHOSPHATE BARIUM SALT DIHYDRATE 99+% D-MANNOHEPTULOSE D-Mannosamine hydrochloride Isomannide α-L-Rhamnopyranose monohydrate L-Mannono-1,4-lactone L -(-)-MANNOSE 99+%,L-MANNOSE, 98%, MIXTURE OF ANOMERS METHYLSILANOL MANNURONATE SODIUM MANNURONATE METHYLSILANOL Oligo-ManA Diaceton-alpha-D-mannofuranose acetochloro-A-D-mannose

  • DL-allo-2,3,4,5,6-Pentahydroxy-hexanal
  • d-[1,2,3-13C3]Mannose
  • d-[1-12C]Mannose (13C depleted at C1)
  • d-[1-13C:1-2H]Mannose
  • d-[1-18O]Mannose
  • d-[2,3,4,5,6-13C5]Mannose
  • d-[3,4-13C2]Mannose
  • d-[UL-12C6]Mannose (13C depleted)
  • d-[UL-13C6:UL-2H7]Mannose
  • d-[UL-2H7]Mannose
  • >=95% (RadiocheMical Purity, HPLC)
  • YM MEDIUM BROTH E
  • D-Mannose(Plant Extract)
  • CARUBINOSE
  • D-MANNOPYRANOSE
  • D-(+)-MANNOSE
  • D-MANNOSE
  • D-MAN
  • MANNOSE, D-(+)-
  • D-MANNOSE extrapure AR
  • D-MANNOSERESEARCH GRADE
  • D-(+)-Mannose,D-Mannopyranose
  • D-(+)-Mannose 99.5%
  • D-(+)-Maose
  • Mannose (300 mg)
  • D-MannMtol
  • Aldohexos
  • NSC 26247
  • (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal
  • D-Mannose - F
  • D-Mannose - F (from birch)
  • 1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethanesulfonyl-&beta
  • 1,2,3,4,6-Penta-O-acetyl-&alpha
  • 2-O-Benzyl-1,3,4-tri-O-acetyl-&alpha
  • 2-O-(2-Deoxy-2-N-phthalimido-3,4,6-tri-O-acetyl-&beta
  • 1,6,2,3-Di(isopropylidene) &beta
  • 2-O-(2-Acetamido-2-deoxy-3,4,6-tri-O-acetyl-&beta
  • -D-glucopyranosyl)-3-O-benzyl-4,6-O-benzylidene-&alpha
  • 3,6-Di-O-(3,4,6-tri-O-acetyl-&beta
  • -D-mannopyranosylethylidyne)-1,2-O-ethylidene-&beta
  • 4-O-Acetyl-3,6-di-O-(2,3,4,6-tetra-O-acetyl-&alpha
  • -D-mannopyranosyl)-1,2|-ethylidene-&beta
  • d mannose E:candyli(at)speedgainpharma(dot)com
  • 99% D-Mannose
  • 4-O-Acetyl-3,6-di-O-(3,4,6-tri-O-acetyl-&beta
  • Benzyl-2-O-(2-Acetamido-2-deoxy-&beta
  • 1,3,4,6-Tetra-O-acetyl-&beta
  • 1,6-Anhydro-2,3-O-(1-isopropylidene)-4-O-(2,3,4,6-tetra-O-acetyl-&alpha
  • 1,6-Anhydro-4-O-(2,3,4,6-tetra-O-acetyl-&alpha
  • SEMINOSE
  • d-mannos
  • D-MANOSE
  • D(+)-MANNOSE SIGMAULTRA
  • D(+)-MANNOSE MIXED ANOMERS*CELL CULTURE TESTED
  • D-MANNOSE, 99%, MIXTURE OF ANOMERS
  • D-(+)-MANNOSE 99.5+% ULTRA PURE
  • D-(+)-MANNOSE 99% CELL CUTLURE REAGENT
  • D-MannoseForBiochemistry99%