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alpha-Methylcinnamic acid

Product Name
alpha-Methylcinnamic acid
CAS No.
1199-77-5
Chemical Name
alpha-Methylcinnamic acid
Synonyms
(E)-2-Methyl-3-phenylacrylic acid;A-METHYLCINNAMIC ACID;2-Methyl-3-phenylacrylic acid;2M3B;α-MethyL;α-Methylciamic acid;RARECHEM AL BM 0531;α-Methylcinmic acid;alpha-Methylcinnamic;α-Methylcinnamicacid
CBNumber
CB1176094
Molecular Formula
C10H10O2
Formula Weight
162.19
MOL File
1199-77-5.mol
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alpha-Methylcinnamic acid Property

Melting point:
79-81 °C(lit.)
Boiling point:
288 °C
Density 
1.0281 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
Sealed in dry,Room Temperature
form 
Crystals or Crystalline Powder
pka
4.82±0.10(Predicted)
color 
White to yellow
BRN 
2042544
InChI
InChI=1S/C10H10O2/c1-8(10(11)12)7-9-5-3-2-4-6-9/h2-7H,1H3,(H,11,12)
InChIKey
XNCRUNXWPDJHGV-BQYQJAHWSA-N
SMILES
C(O)(=O)C(C)=CC1=CC=CC=C1
LogP
2.600
CAS DataBase Reference
1199-77-5(CAS DataBase Reference)
NIST Chemistry Reference
«ALPHA»-methylcinnamic acid(1199-77-5)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29163900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M35606
Product name
α-Methylcinnamic acid
Purity
99%
Packaging
25g
Price
$155
Updated
2025/07/31
Sigma-Aldrich
Product number
M35606
Product name
α-Methylcinnamic acid
Purity
99%
Packaging
100g
Price
$305
Updated
2023/01/07
TCI Chemical
Product number
M1336
Product name
α-Methylcinnamic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$29
Updated
2025/07/31
TCI Chemical
Product number
M1336
Product name
α-Methylcinnamic Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$78
Updated
2025/07/31
TRC
Product number
B495030
Product name
α-Methylcinnamic acid
Packaging
1g
Price
$55
Updated
2021/12/16
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alpha-Methylcinnamic acid Chemical Properties,Usage,Production

Chemical Properties

WHITE TO YELLOWISH CRYSTALS OR CRYSTALLINE POWDER

Uses

Alpha-methylcinnamic acid

Synthesis Reference(s)

Journal of the American Chemical Society, 94, p. 2520, 1972 DOI: 10.1021/ja00762a060
Synthetic Communications, 19, p. 71, 1989 DOI: 10.1080/00397918908050954

Synthesis

100-52-7

123-62-6

1199-77-5

General procedure: Propionic anhydride (300 mmol, 1.6 eq.) was slowly added to a reaction vial containing potassium carbonate (224 mmol, 1.2 eq.) at 0 °C. After stirring for 5 min, benzaldehyde (186 mmol, 1.0 eq.) was added dropwise to the mixture. The reaction mixture was heated to reflux and maintained for 12 hours. Upon completion of the reaction, the mixture was cooled to room temperature using an ice bath, followed by addition of water (appropriate amount) and solid Na2CO3 (30 g) to the reaction mixture. The resulting yellow precipitate was collected by filtration and the filtrate was acidified to pH 6.0 with concentrated HCl to precipitate a solid product of 2-methyl-3-phenylpropenoic acid.

References

[1] Medicinal Chemistry Research, 2004, vol. 13, # 8-9, p. 660 - 676
[2] European Journal of Medicinal Chemistry, 2013, vol. 62, p. 632 - 648
[3] American Chemical Journal, 1906, vol. 36, p. 533
[4] Journal of the Chemical Society, 1877, vol. 31, p. 409
[5] Journal of the Chemical Society, 1878, vol. 33, p. 215

alpha-Methylcinnamic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from alpha-Methylcinnamic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Alpha-Methylcinnamic acid 1199-77-5
Price
US $0.00/G
Min. Order
50G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-02
Hebei Chuanghai Biotechnology Co., Ltd
Product
alpha-Methylcinnamic acid 1199-77-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-15
Hebei Zhuanglai Chemical Trading Co Ltd
Product
alpha-Methylcinnamic acid 1199-77-5
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-11-20

1199-77-5, alpha-Methylcinnamic acidRelated Search:

ALPHA-CYANOCINNAMIC ACID ETHYL ESTER Coumarin-3-carboxylic acid 3-CARBETHOXYUMBELIFERONE DIETHYL BENZYLIDENEMALONATE 2,3-DIPHENYLMALEIC ANHYDRIDE alpha-Phenylcinnamic acid ALPHA-CYANOCINNAMIC ACID Ethyl 2-cyano-3,3-diphenylacrylate ETHYL COUMARIN-3-CARBOXYLATE alpha-Methylcinnamic acid AFLATOXIN G1 ALPHA-CYANO-4-HYDROXYCINNAMIC ACID Cinnamic acid trans-Cinnamic acid 3-CARBOXYUMBELLIFERYL ACETATE ALPHA-CYANO-3-HYDROXYCINNAMIC ACID ETHYL 2-CYANO-3-(4-METHOXYPHENYL)ACRYLATE ETHYL 2-CYANO-3-(4-NITROPHENYL)PROP-2-ENOATE

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  • alpha-Methylcinnamic acid 99%
  • (2E)-2-methyl-3-phenylacrylic acid
  • RARECHEM AL BM 0531
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  • ɑ-Methylcinnamic acid, 99%
  • α-MethylcinnamicAcid&gt
  • Epalrestat Impurity 11 (alpha-Methylcinnamic acid)
  • α-MethyL
  • α-Methylcinnamic acid
  • ALPHA-METHYLCINNAMIC ACID 1199-77-5
  • Epalrestat Impurity 36
  • Lenacapavir Impurity 4
  • Epalrestat 2-methyl-3-phenyl-2-acrylic acid
  • α-Methylcinnamic acid, CAS 1199-77-5
  • α-Methylcinmic acid
  • 1199-77-5
  • 1197-77-5
  • Organic Building Blocks
  • Building Blocks
  • C10
  • Carbonyl Compounds
  • Carboxylic Acids
  • Building Blocks
  • Carbonyl Compounds
  • Carboxylic Acids
  • Chemical Synthesis
  • Organic Building Blocks
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  • C10
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  • Cinnamic acid
  • 1199-77-5
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