ChemicalBook > CAS DataBase List > 1-Amino-4-methylpiperazine

1-Amino-4-methylpiperazine

Product Name
1-Amino-4-methylpiperazine
CAS No.
6928-85-4
Chemical Name
1-Amino-4-methylpiperazine
Synonyms
AMPRZ;1A4MP;1-Amino-4-Methyl;TIMTEC-BB SBB004299;AMINOMETHYLPIPERAZINE;LABOTEST-BB LT00005082;1-piperazinylmethanamine;1-METHYL-4-AMINOPIERAZINE;1-AMINO-4-METHYLPIERAZINE;4-Methyl-1-piperazinamine
CBNumber
CB1177970
Molecular Formula
C5H13N3
Formula Weight
115.18
MOL File
6928-85-4.mol
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1-Amino-4-methylpiperazine Property

Boiling point:
172-175 °C (lit.)
Density 
0.957 g/mL at 25 °C (lit.)
vapor pressure 
1.29hPa at 25℃
refractive index 
1.4835-1.4855
Flash point:
62 °C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
water: soluble
form 
Viscous Solution
pka
7?+-.0.42(Predicted)
color 
Clear
Water Solubility 
miscible
Sensitive 
Air & Light Sensitive
BRN 
103334
InChIKey
RJWLLQWLBMJCFD-UHFFFAOYSA-N
LogP
-1.61 at 25℃
CAS DataBase Reference
6928-85-4(CAS DataBase Reference)
NIST Chemistry Reference
1-Amino-4-methylpiperazine(6928-85-4)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
24/25-36-26
RIDADR 
2733
WGK Germany 
3
HazardClass 
3
PackingGroup 
III
HS Code 
29335995
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
255688
Product name
1-Amino-4-methylpiperazine
Purity
97%
Packaging
25g
Price
$63.27
Updated
2025/07/31
TCI Chemical
Product number
A1192
Product name
1-Amino-4-methylpiperazine
Purity
>98.0%(GC)(T)
Packaging
25mL
Price
$77
Updated
2025/07/31
TCI Chemical
Product number
A1192
Product name
1-Amino-4-methylpiperazine
Purity
>98.0%(GC)(T)
Packaging
500mL
Price
$1141
Updated
2025/07/31
TRC
Product number
A613435
Product name
1-Amino-4-methylpiperazine(>90%)
Packaging
100g
Price
$110
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA75430
Product name
1-Amino-4-methylpiperazine
Packaging
25g
Price
$710.5
Updated
2021/12/16
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1-Amino-4-methylpiperazine Chemical Properties,Usage,Production

Chemical Properties

clear colorless to light yellow liquid

Uses

1-Amino-4-methylpiperazine has been used:
in synthesis of pyrazolo-pyrazine, -pyridine derivatives and 2-[(4-methylpiperazin-1-yl)iminomethyl]phenol
as a solvating and stabilizing agent in the preparation of uniform Ag nanoparticles (<10nm)
synthesis of N-(4-Fluorobenzylidene)-4-methylpiperazin1-amine
synthesis of 4-Methyl-N-(3,4,5-trimethoxybenzylidene) piperazin-1-amine
synthesis of N-(3,4-Dichlorobenzylidene)-4- methylpiperazin-1-amine
synthesis of N-(4-(Diethylamino)benzylidene)-4- methylpiperazin-1-amine
synthesis of N-(2,5-Dimethoxybenzylidene)-4- methylpiperazin-1-amine
synthesis of 4-Methyl-N-((5-nitrofuran-2- yl)methylene)piperazin-1-amine

Application

1-Amino-4-methylpiperazine, a derivative of piperazine, is used widely as an intermediate in the synthesis of pharmaceutical agents. It is an important intermediate for Rifampicin. Rifampicin , known as rifampin, is an antibiotic used to treat a several kinds of bacterial infections such as tuberculosis, leprosy and Legionnare's disease.

Preparation

1-Amino-4-methylpiperazine is obtained from piperazine hexahydrate through the steps of methylation, hydrolysis, nitrosation and reduction.
1-Amino-4-methylpiperazine is synthesized by chlorination of methyl(diethanol)amine (I) and subsequent cyclization of the di(chloroethyl)amine (II) obtained in aqueous hydrazine.

Flammability and Explosibility

Not classified

1-Amino-4-methylpiperazine Preparation Products And Raw materials

Raw materials

ZINC PIPERAZINE HEXAHYDRATE 1-Methylpiperazine Water 1-Piperazinecarbaldehyde

Preparation Products

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1-Amino-4-methylpiperazine Suppliers

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View Lastest Price from 1-Amino-4-methylpiperazine manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.
Product
1-Amino-4-methylpiperazine 6928-85-4
Price
US $1.90/drum
Min. Order
1drum
Purity
99
Supply Ability
200tons
Release date
2025-08-13
Henan Aochuang Chemical Co.,Ltd.
Product
1-Amino-4-methylpiperazine 6928-85-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-29
Shaanxi Dideu New Materials Co. Ltd
Product
1-Amino-4-methylpiperazine 6928-85-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-02-18

6928-85-4, 1-Amino-4-methylpiperazineRelated Search:

BUTYLAMINE HYDROCHLORIDE 1-AMINOHEPTADECANE 1-AMINONONADECANE Rifampicin 4-[(2-METHOXYETHYL)AMINO]-1-METHYLPIPERAZINE 1-AMINO-4-METHYLPIPERAZINE DIHYDROCHLORIDE MONOHYDRATE

  • LABOTEST-BB LT00005082
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  • 1-METHYL-4-AMINOPIPERAZINE
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  • 1-piperazinylmethanamine
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  • 1-Amino-4-methylpiperazine (>90%)
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  • 1-Amino 4-Methyl Piperazine (AMP)
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