ChemicalBook > CAS DataBase List > 3,5-Difluorobenzylamine

3,5-Difluorobenzylamine

Product Name
3,5-Difluorobenzylamine
CAS No.
90390-27-5
Chemical Name
3,5-Difluorobenzylamine
Synonyms
AIDS-011115;RARECHEM AL BW 0274;3,5-Difluorobenzylam;Difluorobenzylamine6;3,5-DIFLUOROBENZYLAMINE;3,5-Difluorobenzylamine >3,5-Difluorobenzylamine 97%;3,5-Difluorobenzylamine,97%;(3,5-Difluorophenyl)methylamine;(3,5-Difluorophenyl)methanamine
CBNumber
CB1184134
Molecular Formula
C7H7F2N
Formula Weight
143.13
MOL File
90390-27-5.mol
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3,5-Difluorobenzylamine Property

Melting point:
261-262 °C(Solv: N,N-dimethylformamide (68-12-2))
Boiling point:
184 °C (lit.)
Density 
1.21 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.491(lit.)
Flash point:
165 °F
storage temp. 
2-8°C(protect from light)
form 
clear liquid
pka
8.54±0.10(Predicted)
color 
Colorless to Almost colorless
Specific Gravity
1.21
Sensitive 
Air Sensitive
BRN 
3538436
InChIKey
VJNGGOMRUHYAMC-UHFFFAOYSA-N
CAS DataBase Reference
90390-27-5(CAS DataBase Reference)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-27-36/37/39-45
RIDADR 
UN 2735 8/PG 2
WGK Germany 
3
Hazard Note 
Corrosive
HazardClass 
8
PackingGroup 
III
HS Code 
29214990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
469351
Product name
3,5-Difluorobenzylamine
Purity
96%
Packaging
1g
Price
$21.5
Updated
2025/07/31
Sigma-Aldrich
Product number
469351
Product name
3,5-Difluorobenzylamine
Purity
96%
Packaging
5g
Price
$62.3
Updated
2025/07/31
TCI Chemical
Product number
D3343
Product name
3,5-Difluorobenzylamine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$29
Updated
2025/07/31
TCI Chemical
Product number
D3343
Product name
3,5-Difluorobenzylamine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$115
Updated
2025/07/31
TRC
Product number
D452160
Product name
3,5-Difluorobenzylamine
Packaging
100mg
Price
$45
Updated
2021/12/16
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3,5-Difluorobenzylamine Chemical Properties,Usage,Production

Chemical Properties

Clear yellow liquid

Uses

3,5-Difluorobenzylamine (DFBA) has been used as a derivatization reagent in the following studies:

  • Determination of epichlorohydrin (ECH) in water by GC/MS analysis in selected ion monitoring (SIM) mode.
  • Analysis of the epoxides 1,2-epoxybutane, epichlorohydrin, and epifluorohydrin in water by GC/MS analysis.
  • Estimation of ECH in water by on-line solid-phase extraction (SPE) coupled to liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) using a triple quadrupole mass spectrometer.

Synthesis

64248-63-1

90390-27-5

General procedure for the synthesis of 3,5-difluorobenzylamine from 3,5-difluorobenzonitrile: 3,5-difluorobenzonitrile (4 g, 28.8 mmol) was added to a nickel Nguyen Nai slurry pre-washed with methanol, which had been treated with ammonia (100 ml) saturated methanol solution. The reaction mixture was shaken under 50 psi hydrogen pressure for 1.5 hours. Upon completion of the reaction, the reaction mixture was filtered and the filtrate evaporated. The residue was dissolved in ethyl acetate and subsequently extracted with 3N hydrochloric acid solution. The acidic aqueous phase was alkalized with 50% sodium hydroxide solution and extracted again with ethyl acetate. The organic phases were combined and concentrated by drying with anhydrous sodium sulfate to give 3.0 g (74% yield) of 3,5-difluorobenzylamine, the product was a yellow oil, which needed to be stored under nitrogen protection.

References

[1] Organic Letters, 1999, vol. 1, # 2, p. 183 - 185
[2] Patent: US4835154, 1989, A
[3] Patent: EP323737, 1989, A1
[4] Journal of Medicinal Chemistry, 1990, vol. 33, # 2, p. 781 - 789
[5] Patent: US4707488, 1987, A

3,5-Difluorobenzylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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3,5-Difluorobenzylamine Suppliers

Americas 1 Belgium 2 China 145 Europe 3 France 2 Germany 5 India 5 Italy 1 Japan 1 Slovakia 1 Switzerland 1 The Netherlands 1 United Kingdom 16 United States 41 Global 225
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Ark Pharm, Inc.
Tel
847-367-3680
Fax
847-367-3681
Email
sales@arkpharminc.com
Country
United States
ProdList
1670
Advantage
56
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11598
Advantage
64
Changzhou Huanling Chemical Co., Ltd.
Tel
0519-89803565 13776850645
Fax
0519-89803575
Email
info4@huanlingchem.com
Country
China
ProdList
891
Advantage
68
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View Lastest Price from 3,5-Difluorobenzylamine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
3,5-Difluorobenzylamine 90390-27-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-12-09
Zhuozhou Wenxi import and Export Co., Ltd
Product
3,5-Difluorobenzylamine 90390-27-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
3,5-Difluorobenzylamine 90390-27-5
Price
US $3.00/ASSAYS
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-09

90390-27-5, 3,5-DifluorobenzylamineRelated Search:

N-Methylbenzylamine 4-(Aminomethyl)benzoic acid Trimethoprim Phenoxybenzamine hydrochloride 4-Fluorobenzylamine 4-AMINO-2,3,5,6-TETRAFLUOROBENZAMIDE 3,4,5-Trifluorobenzylamine 2,3,4,5,6-PENTAFLUOROBENZAMIDE 3,5-DIFLUOROBENZAMIDE N-PENTAFLUOROBENZOYLIMIDAZOLE 2,3,5-Trifluorobenzyl amine 3,4-DIFLUOROBENZYLAMINE,3,4-Difluorobenzylamine 99%,3, 4-DIFLUOROBENZYLAMINE,98%,3,4-Difluorobenzylamine99% 3-CHLORO-2,6-DIFLUOROBENZYLAMINE,3-Chloro-2,6-difluorobenzylamine 98%,3-Chloro-2,6-difluorobenzylamine98% 2,5-Difluorobenzylamine97%,2,5-Difluorobenzylamine 97%,2,5-DIFLUOROBENZYLAMINE 2,4-DIFLUOROBENZYLAMINE,2,4-Difluorobenzylamine 97%,2,4-Difluorobenzylamine97%,2,4-DIFLUOROBENZYLAMINE HYDROCHLORIDE,2,4-Difluorobenzylamine, 98+% 3-CHLORO-2,4-DIFLUOROBENZYLAMINE 2,3-Difluorobenzylamine98%,2,3-Difluorobenzylamine 98%,Difluorobenzylamine1,2,3-DIFLUOROBENZYLAMINE ZINC 1,2,3,4,8,9,10,11,15,16,17,18,22,23,24,25-HEXADECAFLUORO-29H,31H-PHTHALOCYANINE

  • RARECHEM AL BW 0274
  • 3,5-DIFLUOROBENZYLAMINE
  • AIDS-011115
  • 3,5-Difluorobenzylamine 97%
  • Difluorobenzylamine6
  • 3,5-Difluorobenzylamine,97%
  • (3,5-Difluorophenyl)methanamine
  • (3,5-Difluorophenyl)methylamine
  • 3,5-Difluorobenzylam
  • 1-(3,5-Difluorophenyl)methylamine
  • 3,5-Difluorobenzylamine &gt
  • Benzenemethanamine, 3,5-difluoro-
  • 90390-27-5
  • 90396-27-5
  • Building Blocks
  • Amines
  • C7
  • Nitrogen Compounds
  • Organic Building Blocks
  • Fluorine series
  • Amine
  • Miscellaneous
  • Amines
  • C7
  • Nitrogen Compounds