5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER
Application- Product Name
- 5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER
- CAS No.
- 773873-77-1
- Chemical Name
- 5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER
- Synonyms
- RARECHEM AL BF 0374;Methyl 5-BroMoindole-3-carboxylate;METHYL 5-BROMO-1H-INDOLE-3-CARBOXYLATE;1H-Indole-3-carboxylicacid,5-broMo-,Methylester;5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER;5-Bromo-1H-Indole-3-Carboxylic Acid Methyl Ester, 10 mM in DMSO
- CBNumber
- CB1191525
- Molecular Formula
- C10H8BrNO2
- Formula Weight
- 254.08
- MOL File
- 773873-77-1.mol
5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER Property
- Melting point:
- 212-214 °C
- Boiling point:
- 386.2±22.0 °C(Predicted)
- Density
- 1.629±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.46±0.30(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 773873-77-1
Safety
- HS Code
- 2933998090
N-Bromosuccinimide Price
- Product number
- M295663
- Product name
- Methyl5-Bromoindole-3-carboxylate
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- W8396
- Product name
- Methyl5-bromo-1H-indole-3-carboxylate
- Packaging
- 1g
- Price
- $41
- Updated
- 2021/12/16
- Product number
- OR962104
- Product name
- Methyl5-bromo-1H-indole-3-carboxylate
- Purity
- 98%
- Packaging
- 5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- J51148
- Product name
- Methyl5-bromo-1H-indole-3-carboxylate
- Packaging
- 5g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 073274
- Product name
- Methyl 5-bromo-1H-indole-3-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $82
- Updated
- 2021/12/16
5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER Chemical Properties,Usage,Production
Application
Methyl 5-bromoindole-3-carboxylic acid can be used as an organic synthesis intermediate. It can be prepared in two steps from 5-bromo-1H-indole as a reactant, or it can be obtained by one-step esterification of 5-bromo-1H-indole-3-carboxylic acid.
Synthesis
67-56-1
10406-06-1
773873-77-1
GENERAL METHOD: 4.0 g of 5-bromo-1H-indole-3-carboxylic acid was dissolved in 40 times the volume (400 mL) of methanol and a catalytic amount of concentrated sulfuric acid was slowly added. The reaction mixture was heated to reflux for 5 hours, followed by slow cooling to room temperature. Ice-cold water was added to the cooled mixture and the yellow solid was collected by filtration. The solid was recrystallized from ethanol to give methyl 5-bromo-indole-3-carboxylate (12b) as a yellow solid in 62% yield. The product characterization data were as follows: melting point: 210-212 °C; IR (KBr, cm-1): 3213, 3114, 2929, 1745; 1H NMR (400 MHz, CDCl3): δ 3.93 (3H, s, -OCH3), 7.28 (1H, d, J = 8.8 Hz, Ar-H), 7.35 (1H, m, Ar-H ), 7.91 (1H, d, J = 2.8 Hz, Ar-H), 8.32 (1H, s, Ar-H), 8.67 (1H, s, -NH); 13C NMR (400 MHz, CDCl3 + DMSO-d6): δ 49.93, 105.91, 112.88, 113.75, 122.40, 124.26, 126.65, 131.89, 134.33, 164.13; HRMS (m/z): calculated value C10H9NO2Br [M]+: 253.98112, measured value: 253.98102.
References
[1] Chemical Papers, 2018, vol. 72, # 6, p. 1369 - 1378
5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER Suppliers
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 4009903999 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18729
- Advantage
- 57
- Tel
- 0086-21-58956006
- Fax
- 0086-21-58956100
- Country
- China
- ProdList
- 7811
- Advantage
- 57
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- 021-56491756 13512199871
- Fax
- 021-5649-1756
- 2819742715@qq.com
- Country
- China
- ProdList
- 4000
- Advantage
- 55
- Tel
- 18986259541
- Fax
- 027-87840182
- sales@3stc.com
- Country
- China
- ProdList
- 3763
- Advantage
- 58
- Tel
- 028-85114309 18982182443
- yangli@happysyn.com
- Country
- China
- ProdList
- 2150
- Advantage
- 55
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10266
- Advantage
- 58
View Lastest Price from 5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER manufacturers
- Product
- 5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER 773873-77-1
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08
- Product
- 5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID METHYL ESTER 773873-77-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-08