QX 314 chloride
- Product Name
- QX 314 chloride
- CAS No.
- 5369-03-9
- Chemical Name
- QX 314 chloride
- Synonyms
- QX314.Cl;QX 314 CHLORIDE;N-Ethyllidocaine chloride;Lidocaine N-ethyl chloride;QX-314;QX314;N-ETHYLLIDOCAINE CHLORIDE;[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium chloride;N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE;[2-(2,6-dimethylanilino)-2-keto-ethyl]-triethyl-ammonium chloride;[2-[(2,6-dimethylphenyl)amino]-2-oxo-ethyl]-triethyl-azanium chloride;2-(2,6-Dimethylphenylamino)-N,N,N-triethyl-2-oxoethanaminium chloride
- CBNumber
- CB1191994
- Molecular Formula
- C16H27ClN2O
- Formula Weight
- 298.85
- MOL File
- 5369-03-9.mol
QX 314 chloride Property
- Melting point:
- 209-211 °C
- storage temp.
- Room temp
- solubility
- insoluble in EtOH; ≥14.95 mg/mL in DMSO with gentle warming; ≥22.3 mg/mL in H2O
- form
- solid
- color
- White
- Water Solubility
- Soluble in water (100mM)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- L1663
- Product name
- Lidocaine N-ethyl chloride
- Packaging
- 500MG
- Price
- $315
- Updated
- 2023/06/20
- Product number
- L1663
- Product name
- Lidocaine N-ethyl chloride
- Packaging
- 1G
- Price
- $579
- Updated
- 2023/06/20
- Product number
- 18454
- Product name
- QX-314 (chloride)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 2313
- Product name
- QX314chloride
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $139
- Updated
- 2021/12/16
- Product number
- Q950010
- Product name
- QX314Chloride
- Packaging
- 50mg
- Price
- $130
- Updated
- 2021/12/16
QX 314 chloride Chemical Properties,Usage,Production
Uses
QX 314 Chloride has been shown to have antitussive properties in mammalian animal models.
Uses
QX 314 chloride is a membrane-impermeant lidocaine derivative that selectively blocks sodium channels on nociceptive neurons when delivered intracellularly via the TRPV1 channel, but is reportedly ineffective with extracellular application. When supplied in combination with 1 μM capsaicin , a TRPV1 receptor agonist, 5 mM QX-314 blocks 98% of sodium current in voltage-clamped nociceptive DRG neurons. QX 314 chloride elicits a long-lasting decrease in the response to painful mechanical and thermal stimuli without imparting the motor deficits (e.g., numbness, paralysis) associated with many conventional local anesthetics. At concentrations ranging from 10-70 mM, peripheral application of QX 314 chloride dose-dependently produces robust local anesthesia with slow onset in the guinea pig intradermal wheal assay, the mouse tail-flick test, and the mouse sciatic nerve blockade model.
Biological Activity
Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na + channels.
Biochem/physiol Actions
Lidocaine N-ethyl chloride is an intracellular voltage-gated sodium channel blocker.
storage
Room temperature