ChemicalBook > CAS DataBase List > 4-Hydrazinobenzene-1-sulfonamide hydrochloride

4-Hydrazinobenzene-1-sulfonamide hydrochloride

Product Name
4-Hydrazinobenzene-1-sulfonamide hydrochloride
CAS No.
17852-52-7
Chemical Name
4-Hydrazinobenzene-1-sulfonamide hydrochloride
Synonyms
BENZENESULPHONAMIDE;Celecoxib Intermediate;4-Hydrazinobenzene-1-sulfonaMide;4-Sulfonamidophenylhydrazine hydrochloride;4-SPH;4-SAPH.HCl;fonamide HydrochL;4-SPH/Sulfonamide;4-Hydrazinobenzene-1;Deracoxib Impurity 3
CBNumber
CB1200737
Molecular Formula
C6H10ClN3O2S
Formula Weight
223.68
MOL File
17852-52-7.mol
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4-Hydrazinobenzene-1-sulfonamide hydrochloride Property

Melting point:
149-152 °C(lit.)
Density 
1.644[at 20℃]
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Methanol (Slightly, Heated), Water (Slightly)
form 
powder to crystal
color 
White to Light yellow to Light orange
Water Solubility 
Soluble in water.
Sensitive 
Hygroscopic
InChI
InChI=1S/C6H9N3O2S.ClH/c7-9-5-1-3-6(4-2-5)12(8,10)11;/h1-4,9H,7H2,(H2,8,10,11);1H
InChIKey
IKEURONJLPUALY-UHFFFAOYSA-N
SMILES
C1(S(=O)(=O)N)C=CC(NN)=CC=1.Cl
LogP
-0.99 at 20℃
CAS DataBase Reference
17852-52-7(CAS DataBase Reference)
EPA Substance Registry System
Benzenesulfonamide, 4-hydrazinyl-, hydrochloride (1:1) (17852-52-7)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
36-24/25
WGK Germany 
3
RTECS 
DA9380000
Hazard Note 
Irritant
HS Code 
29350090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS003887
Product name
4-sulfonamidophenylhydrazine hydrochloride
Purity
AldrichCPR
Packaging
250mg
Price
$81.6
Updated
2023/01/07
TCI Chemical
Product number
H1230
Product name
4-Hydrazinobenzenesulfonamide Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$31
Updated
2025/07/31
TCI Chemical
Product number
H1230
Product name
4-Hydrazinobenzenesulfonamide Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$95
Updated
2025/07/31
TRC
Product number
S699078
Product name
(4-Sulfamoylphenyl)hydrazineHydrochloride
Packaging
5g
Price
$250
Updated
2021/12/16
Usbiological
Product number
289447
Product name
4-Sulfonamidophenylhydrazine hydrochloride
Packaging
25g
Price
$312
Updated
2021/12/16
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4-Hydrazinobenzene-1-sulfonamide hydrochloride Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

Intermediate in the production of Celebrex.

Uses

It is a potentially useful intermediate in the production of Celebrex an anti inflammatory drug.

Flammability and Explosibility

Non flammable

Synthesis

63-74-1

17852-52-7

The general procedure for the synthesis of p-hydrazinylbenzenesulfonamide hydrochloride from crystalline sulfanilamide was as follows: firstly, 4'-methylacetophenone was reacted with succinic anhydride in the presence of diisopropanolamine (LDA) and tetrahydrofuran (THF) for 1 hr at -78 °C to afford p-tolyl-4,6-dioxohexanoic acid in 66% yield and the product was a white solid. Subsequently, the sulfonamide was reacted with sodium nitrite (NaNO2) and concentrated hydrochloric acid for 30 min at 0-4 °C, followed by the addition of tin(II) chloride (SnCl2), and the reaction was continued for 4 h at 0 °C to produce 4-sulfonylaminophenylhydrazine hydrochloride in 55% yield, the product being a pale yellow solid. Finally, p-tolyl-4,6-dioxohexanoic acid was reacted with 4-sulfonylaminophenylhydrazine hydrochloride in a methanolic solution of triethanolamine (TEA) at room temperature for 16 h to give compound 30c, 3-[1-{p-(p-(sulfonylamino)phenyl}-5-p-tolyl-1H-pyrazol-3-yl]propanoic acid in 76% yield and the product was a yellow solid.

References

[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 18, p. 4444 - 4452
[2] Organic Letters, 2012, vol. 14, # 19, p. 5030 - 5033,4
[3] Journal of Heterocyclic Chemistry, 2018, vol. 55, # 4, p. 913 - 922
[4] Patent: US2007/292352, 2007, A1. Location in patent: Page/Page column 45-46
[5] Patent: US2003/236294, 2003, A1. Location in patent: Page 9

4-Hydrazinobenzene-1-sulfonamide hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Hydrazinobenzene-1-sulfonamide hydrochloride Suppliers

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View Lastest Price from 4-Hydrazinobenzene-1-sulfonamide hydrochloride manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Hydrazinobenzene-1-sulfonamide hydrochloride 17852-52-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-29
Hebei Yanxi Chemical Co., Ltd.
Product
4-Hydrazinobenzene-1-sulfonamide hydrochloride 17852-52-7
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
1000kg
Release date
2023-09-06
Hebei Chuanghai Biotechnology Co,.LTD
Product
4-Hydrazinobenzene-1-Sulfonamide Hydrochloride 17852-52-7
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-20

17852-52-7, 4-Hydrazinobenzene-1-sulfonamide hydrochlorideRelated Search:

Hydrazine monohydrochloride Sulfanilamide Benzenesulfonamide Benzoyl hydrazine Topotecan hydrochloride 4-Methylbenzenesulfonhydrazide 1,5-Diphenylcarbazide Phenylhydrazine hydrochloride 4-AMINOAZOBENZENE HYDROCHLORIDE D-Glucosamine hydrochloride Celecoxib Trifluro Impurity 5-(TRIFLUOROMETHYL)-3-P-TOLYL-1H-PYRAZOLE 4-[5-hydroxy-3-(4-methylphenyl)-5-(trifluoromethyl)-4H-pyrazol-1-yl]benzenesulfonamide Celecoxib Impurity 6 Celecoxib iMpurity-G Celecoxib IMpurity 1 Celecoxib Impurity 2 Celecoxib Impurity

  • 4-SPH
  • 4-Sulphamoylphenylhydrazine hydrochloride, 4-(Aminosulphonyl)phenylhydrazine hydrochloride
  • p-Sulfonamidophenylhydrazine
  • 4-Hydrazinobenzene-1
  • 4-Aminosulfonylphenylhydrazine hydrochloride
  • 4-Hydrazinobenzene-1-sulfonamide hydrochloride
  • 4-Sulfonamidophenylhydrazine hydrochloride
  • 4-SAPH.HCl
  • Celecoxib Impurity 10 HCl
  • p-Sulfonamidophenylhydrazine HCl
  • 4-Hydrazinobenzene-1-sulfonaMide
  • Deracoxib Impurity 3
  • (E)-4-(2-(1-(o-tolyl)ethylidene)hydrazinyl)benzenesulfonamide
  • Celecoxib Intermediate
  • 4-Hydrazinobenzenesulphonamide hydrochloride 99%
  • Celecoxib Hydrazine Impurity
  • Celecoxib Impurity HCl (4-Hydrazinobenzene-1-sulfonamide HCl)
  • 4-(sulfaMoylphenyl)hydrazine Monohydrochloride
  • 4-Hydrazine benzene sulfonaMide hydrochloride
  • 4-AMinosulfonylphenylhydrazine HCl
  • Hydrazine benzene sulfonamide hydrochloride
  • Thehydrazinebenzene sulfonaMidehydrochloride
  • 4-Hydrazinobenzene-1-sulfonamide hydrochloride (Celecoxib)
  • BENZENESULFONYLAMIDE
  • BENZENESULPHONAMIDE
  • 4-HYDRAZINOBENZENE-1-SULFONAMIDE HCL
  • Celecoxib hydrochloride impurities (4-hydrazinophenyl-1-sulfonamide hydrochloride)
  • 4-HydrazinobenzenesulfonamideHydrochloride&gt
  • Celecoxib Impurity HCl
  • fonamide HydrochL
  • Benzenesulfonamide, 4-hydrazinyl-, hydrochloride (1:1)
  • 4- hydrazine-benzene-1-sulfonamide hydrochloride
  • 4-Hydrazinobenzene-1-sulfonamide hydrochloride ISO 9001：2015 REACH
  • 4-Hydrazinobenzene-1-Sulfonamide Hydrochloride4-Hydrazinobenzene-1-Sulfonamide Hydrochloride 4-Hydrazinobenzene-1-Sulfonamide Hydrochloride
  • 4-Hydrarazinobenzene sulfonamide Hydrochloride
  • 4-Sulphanamido Phenyl Hydrazine Hydrochloride
  • 4-Sulphanamido Phenyl Hydrazine Hydrochloride (4-SAPH)
  • 4-sulphanamido phenyl hydrazine Hydrochloride (4-SPH)
  • 4-Hydrazino Benzene Sulfonamide Hydrochloride (Can be offered in Free base form also - CAS No. 4392-54-5
  • 4-Sulphonamido Phenyl Hydrazine Hydrochloride(4-SPH)
  • 4-Sulfonamido Phenyl Hydrazine Hydrochloride (4SPH HCL)
  • OR 4-Hydrazinobenzenesulfonamide HCL
  • 4-Hydrazinyl-1-Sulfonamide—Hydrogen Chloride
  • 4-sulphanamido phenyl hydrazine HCL (4-SPH)
  • 4-SPH/Sulfonamide
  • 4-Hydrazino Benzene Sulfonamide HCI
  • 4-Hydrazinylbenzen-1-Sulfonamide-Hydrogen Chloride
  • 4-Suphonamido Phenyl Hydrazine HCL
  • Celecoxib Impurity 21 HCl
  • Acrylamide Impurity 4
  • Sulfonamide benzyl chloride
  • 4-hydrazylbenzene sulfonamide hydrochloride
  • Celecoxib Hydrazine Impurity 4-Sulphonamido phenyl hydrazine hydrochloride
  • Celecoxib Impurity 36 Hydrochloride
  • (4-Sulfamoylpheny)hydrazine monohydrochloride
  • p-Hydrazinobenzenesulfonamide hydrochloride (4-SAPH)
  • Sulfonamide phenyl hydrazine hydrochloride
  • p-Sulfamoylphenylhydrazine hydrochloride