4-Hydrazinobenzene-1-sulfonamide hydrochloride
- Product Name
- 4-Hydrazinobenzene-1-sulfonamide hydrochloride
- CAS No.
- 17852-52-7
- Chemical Name
- 4-Hydrazinobenzene-1-sulfonamide hydrochloride
- Synonyms
- BENZENESULPHONAMIDE;Celecoxib Intermediate;4-Hydrazinobenzene-1-sulfonaMide;4-Sulfonamidophenylhydrazine hydrochloride;4-SPH;4-SAPH.HCl;fonamide HydrochL;4-SPH/Sulfonamide;4-Hydrazinobenzene-1;Deracoxib Impurity 3
- CBNumber
- CB1200737
- Molecular Formula
- C6H10ClN3O2S
- Formula Weight
- 223.68
- MOL File
- 17852-52-7.mol
4-Hydrazinobenzene-1-sulfonamide hydrochloride Property
- Melting point:
- 149-152 °C(lit.)
- Density
- 1.644[at 20℃]
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Methanol (Slightly, Heated), Water (Slightly)
- form
- powder to crystal
- color
- White to Light yellow to Light orange
- Water Solubility
- Soluble in water.
- Sensitive
- Hygroscopic
- InChI
- InChI=1S/C6H9N3O2S.ClH/c7-9-5-1-3-6(4-2-5)12(8,10)11;/h1-4,9H,7H2,(H2,8,10,11);1H
- InChIKey
- IKEURONJLPUALY-UHFFFAOYSA-N
- SMILES
- C1(S(=O)(=O)N)C=CC(NN)=CC=1.Cl
- LogP
- -0.99 at 20℃
- CAS DataBase Reference
- 17852-52-7(CAS DataBase Reference)
- EPA Substance Registry System
- Benzenesulfonamide, 4-hydrazinyl-, hydrochloride (1:1) (17852-52-7)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 36-24/25
- WGK Germany
- 3
- RTECS
- DA9380000
- Hazard Note
- Irritant
- HS Code
- 29350090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- CDS003887
- Product name
- 4-sulfonamidophenylhydrazine hydrochloride
- Purity
- AldrichCPR
- Packaging
- 250mg
- Price
- $81.6
- Updated
- 2023/01/07
- Product number
- H1230
- Product name
- 4-Hydrazinobenzenesulfonamide Hydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $31
- Updated
- 2025/07/31
- Product number
- H1230
- Product name
- 4-Hydrazinobenzenesulfonamide Hydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $95
- Updated
- 2025/07/31
- Product number
- S699078
- Product name
- (4-Sulfamoylphenyl)hydrazineHydrochloride
- Packaging
- 5g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 289447
- Product name
- 4-Sulfonamidophenylhydrazine hydrochloride
- Packaging
- 25g
- Price
- $312
- Updated
- 2021/12/16
4-Hydrazinobenzene-1-sulfonamide hydrochloride Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powde
Uses
Intermediate in the production of Celebrex.
Uses
It is a potentially useful intermediate in the production of Celebrex an anti inflammatory drug.
Flammability and Explosibility
Non flammable
Synthesis
63-74-1
17852-52-7
The general procedure for the synthesis of p-hydrazinylbenzenesulfonamide hydrochloride from crystalline sulfanilamide was as follows: firstly, 4'-methylacetophenone was reacted with succinic anhydride in the presence of diisopropanolamine (LDA) and tetrahydrofuran (THF) for 1 hr at -78 °C to afford p-tolyl-4,6-dioxohexanoic acid in 66% yield and the product was a white solid. Subsequently, the sulfonamide was reacted with sodium nitrite (NaNO2) and concentrated hydrochloric acid for 30 min at 0-4 °C, followed by the addition of tin(II) chloride (SnCl2), and the reaction was continued for 4 h at 0 °C to produce 4-sulfonylaminophenylhydrazine hydrochloride in 55% yield, the product being a pale yellow solid. Finally, p-tolyl-4,6-dioxohexanoic acid was reacted with 4-sulfonylaminophenylhydrazine hydrochloride in a methanolic solution of triethanolamine (TEA) at room temperature for 16 h to give compound 30c, 3-[1-{p-(p-(sulfonylamino)phenyl}-5-p-tolyl-1H-pyrazol-3-yl]propanoic acid in 76% yield and the product was a yellow solid.
References
[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 18, p. 4444 - 4452
[2] Organic Letters, 2012, vol. 14, # 19, p. 5030 - 5033,4
[3] Journal of Heterocyclic Chemistry, 2018, vol. 55, # 4, p. 913 - 922
[4] Patent: US2007/292352, 2007, A1. Location in patent: Page/Page column 45-46
[5] Patent: US2003/236294, 2003, A1. Location in patent: Page 9
4-Hydrazinobenzene-1-sulfonamide hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
4-Hydrazinobenzene-1-sulfonamide hydrochloride Suppliers
- Tel
- --
- Fax
- --
- y.barysheva@ukrorgsynth.com
- Country
- Ukraine
- ProdList
- 6230
- Advantage
- 38
View Lastest Price from 4-Hydrazinobenzene-1-sulfonamide hydrochloride manufacturers
- Product
- 4-Hydrazinobenzene-1-sulfonamide hydrochloride 17852-52-7
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-29
- Product
- 4-Hydrazinobenzene-1-sulfonamide hydrochloride 17852-52-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 1000kg
- Release date
- 2023-09-06
- Product
- 4-Hydrazinobenzene-1-Sulfonamide Hydrochloride 17852-52-7
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-20