L-Glutathione

ChemicalBook > CAS DataBase List > L-Glutathione

Product Name: L-Glutathione
CAS No.: 27025-41-8
Chemical Name: L-Glutathione
Synonyms: GSSG;L-GLUTATHIONE OXIDIZED;GLUTATHIONE DISULFIDE;Oxiglutatione;oxidizedglutathione;L-GLUTATHIONE OXIDISED;GSSC;NOV-002;Glutathiol;oxigluthione
CBNumber: CB1200803
Molecular Formula: C20H32N6O12S2
Formula Weight: 612.63
MOL File: 27025-41-8.mol

Less

L-Glutathione Property

Melting point:: 178 °C (dec.)(lit.)
alpha: -99 º (c=4, water)
Density: 1.3688 (rough estimate)
refractive index: -105 ° (C=2, H2O)
storage temp.: 2-8°C
solubility: H₂O: soluble
form: powder
pka: 2.12, 3.59, 8.75, 9.65(at 25℃)
color: White to off-white
Water Solubility: soluble
Merck: 13,4488
BRN: 1718700
Stability:: Stable. Incompatible with strong oxidizing agents.
InChIKey: YPZRWBKMTBYPTK-USZNOCQGSA-N
CAS DataBase Reference: 27025-41-8(CAS DataBase Reference)
EPA Substance Registry System: Oxiglutatione (27025-41-8)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-24/25-36/37/39-27-37/39
WGK Germany: 2
RTECS: MC0556500
HS Code: 29309090
Toxicity: mouse,LD50,intravenous,> 2gm/kg (2000mg/kg),Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 6793, 1989.

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G2299
Product name: L-Glutathione oxidized
Purity: PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production.
Packaging: 100g
Price: $1586
Updated: 2024/03/01

Sigma-Aldrich

Product number: G2299
Product name: L-Glutathione oxidized
Purity: PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production.
Packaging: 1kg
Price: $10456
Updated: 2024/03/01

Sigma-Aldrich

Product number: 3542
Product name: Glutathione, Oxidized, Free Acid - CAS 27025-41-8 - Calbiochem
Purity: Glutathione,Oxidized,FreeAcid,CAS27025-41-8,formsa"redoxbuffer"inphys
Packaging: 1g
Price: $96.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: 3542
Product name: Glutathione, Oxidized, Free Acid - CAS 27025-41-8 - Calbiochem
Purity: Glutathione,Oxidized,FreeAcid,CAS27025-41-8,formsa"redoxbuffer"inphys
Packaging: 5G
Price: $265
Updated: 2024/03/01

TCI Chemical

Product number: G0073
Product name: Glutathione oxidized form
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $64
Updated: 2024/03/01

Less

L-Glutathione Chemical Properties,Usage,Production

Description

L-Glutathione oxidized(GSSG) is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of it. It can be used for the research of sickle cells and erythrocytes. The ratio of glutathione (GSH) to oxidised glutathione (GSSG) is a key indicator of cellular oxidative stress. It can be used in the clinical diagnosis and treatment of leukaemia by detecting the level of cellular GSH/GSSG in acute myeloid leukaemia (AML), which is characterised by oxidative stress leading to abnormally low levels of oxidised glutathione, with real-time, dynamic and highly sensitive characteristics^[1].

Chemical Properties

White lyophilized powder

Uses

S,S'-Ethylenebis(glutathione) is a haloethane-glutathione conjugate formed via GSH transferases. S,S'-Ethylenebis(glutathione) formation is used to study the polymorphism in glutathione conjugation ac tivity of human erythrocytes towards ethylene dibromide.

Uses

L-Glutathione is used as a Acts as hydrogen acceptor in enzymatic determination of NADP and NADPH, it is used to reduced back to glutathione (GSH) via the NADPH-dependent enzyme glutathione reductase. The ratio of GSH to GSSG is often used to gauge the level of oxidative stress in cells, with higher concentrations of GSSG implying more oxidative stress

Uses

L(-)-Glutathione is a biomarker for fatty liver disease.

Application

L-Glutathione (GSH) has been used in the elution buffer to elute GST (glutathione S-transferase)-fused proteins using glutathione-agarose beads. It has been used to prepare a standard curve for GSH analyses. May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.

Definition

ChEBI: Glutathione disulfide is an organic disulfide and a glutathione derivative. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a glutathione disulfide(2-).

Biochem/physiol Actions

L-Glutathione, oxidized is frequently measure in vivo as an indicator of oxidative stress. Oxidized L-Glutathione may be converted to L-glutathione by various reducing systems.

Side effects

There have been few studies on the side effects of glutathione use, and as a supplement, no associated side effects have been reported from consuming high glutathione only from diet. However, long-term use of glutathione supplements may reduce zinc levels, and inhaling glutathione can cause breathing problems in some people with mild asthma. In addition, there are concerns that the use of glutathione supplements may cause cramps and bloating or allergic reactions, accompanied by symptoms such as rashes. If you experience any of these side effects, stop taking the supplement and contact your doctor.

Purification Methods

Purify it by recrystallisation from 50% aqueous EtOH. Its solubility in H2O is 5%. Store it at 4o. [Li et al. J Am Chem Soc 76 225 1954, Berse et al. Can J Chem 37 1733 1959, Beilstein 4 IV 3168.]

References

[1] ABBASGHULAM. Construction of Genetically Encoded Biosensors to Monitor Subcellular Compartment-Specific Glutathione Response to Chemotherapeutic Drugs in Acute Myeloid Leukemia Cells.[J]. Analytical Chemistry, 2023, 95 5: 2838-2847. DOI:10.1021/acs.analchem.2c04255.

L-Glutathione Preparation Products And Raw materials

Raw materials

Preparation Products

Less

L-Glutathione Suppliers

Americas 1 Belgium 1 Canada 5 China 372 China Hong Kong 1 Europe 3 France 2 Germany 11 India 22 Japan 7 Poland 1 Switzerland 5 Ukraine 1 United Kingdom 11 United States 51 Global 494

Wuhan Huajiu Pharmaceutical Technology Co.,Ltd.

Tel: 027-59225746 18062681621
Fax: 027-59225746
Email: 730880265@qq.com
Country: China
ProdList: 4794
Advantage: 58

Shanghai Baoman Biotechnology Co., Ltd.

Tel: 021-62130998
Fax: 021-54438215
Email: baomanbio@163.com
Country: China
ProdList: 105
Advantage: 55

Shanghai QianJin Chemical Technology Co., Ltd

Tel: 021-20900665 17321230821
Fax: 021-20900665
Email: 2986274987@qq.com
Country: China
ProdList: 982
Advantage: 55

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 400-400-400-9004166 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52712
Advantage: 58

Nanjing Search Biotech Co., Ltd

Tel: +86-025-81682922 +86-13515111588
Fax: 025-85860962
Email: sales@searchbio.com.cn
Country: China
ProdList: 135
Advantage: 68

Hubei Chanmol Biotech Co., Ltd.

Tel: 0711-3812399 18062309155
Email: 156941107@qq.com
Country: China
ProdList: 2987
Advantage: 58

Guangzhou Dreampharm Biotechnology Co., Ltd.

Tel: 17825480238
Fax: QQ 3008233717
Email: 3008233717@qq.com
Country: China
ProdList: 9844
Advantage: 12

Nanjing Endesa Bio-tech Co., Ltd.

Tel: 025-58862853 18915922038
Fax: +86-025-58862853
Email: sales@endesachem.com
Country: China
ProdList: 592
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006608290; 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40241
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

BeiJing Hwrk Chemicals Limted

Tel: 0757-86329057 18501085097
Fax: 010-89508210
Email: sales3.gd@hwrkchemical.com
Country: China
ProdList: 7583
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44751
Advantage: 61

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: zhangsn@titansci.com
Country: China
ProdList: 14113
Advantage: 59

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 17987
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696;
Email: info@hanhongsci.com
Country: China
ProdList: 42982
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Shandong Xiya Chemical Co., Ltd

Tel: 13355009207 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18739
Advantage: 57

Tangshan Moneide Trading Co., Ltd.

Tel: 0315-8309571 15633399667
Fax: +86-315-7726572
Email: sales@moneidechem.com
Country: China
ProdList: 704
Advantage: 57

BEST-REAGENT

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11726
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14443
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9823
Advantage: 79

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 4550
Advantage: 62

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9664
Advantage: 60

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2893
Advantage: 58

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4647
Advantage: 58

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4941
Advantage: 60

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9872
Advantage: 52

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17779
Advantage: 75

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12338
Advantage: 58

Beijing innoChem Science & Technology Co.,Ltd.

Tel: 400-810-7969 010-59572699
Fax: 010-59572688
Email: ningzi.li@inno-chem.com.cn
Country: China
ProdList: 6139
Advantage: 55

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1494
Advantage: 55

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9901
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66099280 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19918
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22519
Advantage: 55

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: +86 (21) 5895-8628
Email: SALES@UHNSHANGHAI.COM
Country: China
ProdList: 977
Advantage: 58

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 18521735133 18521732826;
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25015
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9552
Advantage: 55

Shanghai Ruji Biology Technology Co., Ltd.

Tel: +86-21-65211385-8001 36031160
Fax: +86-21-65211385-8004
Email: sales@shruji.com
Country: China
ProdList: 3224
Advantage: 55

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3989
Advantage: 66

Nanjing Dulai Biotechnology Co., Ltd.

Tel: 025-84699383-8003 18013301590
Fax: 025-84699383-8003
Email: njduly@126.com
Country: China
ProdList: 973
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7934
Advantage: 58

Shanghai BeiZhuo Biotech Co., Ltd.

Tel: 021-61119791,13386096464
Fax: 021-50190009
Email: bzswkf@foxmail.com
Country: China
ProdList: 3924
Advantage: 50

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9986
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-1647117 15221909166
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41438
Advantage: 60

Shanghai DiBai Chemicals Co., Ltd.

Tel: 021-54359730 400-008-9730
Fax: 021-54353864
Email: info@chemxyz.com
Country: China
ProdList: 3993
Advantage: 60

Zhengzhou HongSheng Pharmaceutical Co., Ltd.

Tel: 1352-6885213 15637198702
Fax: 0371-63709726
Email: xpkchem@163.com
Country: China
ProdList: 3998
Advantage: 58

Shanghai GaoLang Chemical Technology Co., Ltd.

Tel: 021-57340939 18017297327
Fax: 021-37210791
Email: sales@gaolangchemical.com
Country: China
ProdList: 888
Advantage: 55

Less

View Lastest Price from L-Glutathione manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.

Product: L(-)-Glutathione 27025-41-8
Price: US $0.00/G
Min. Order: 1G
Purity: 98% HPLC
Supply Ability: 1000KG
Release date: 2022-09-19

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: L-Glutathione 27025-41-8
Price: US $20.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 200000kg
Release date: 2024-04-24

Hebei Saisier Technology Co., LTD

Product: L(-)-Glutathione 27025-41-8
Price: US $6.00/KG
Min. Order: 1KG
Purity: More than 99%
Supply Ability: 2000KG/Month
Release date: 2024-04-23

27025-41-8, L-GlutathioneRelated Search:

REDUCED GLUTATHIONE,L-GLUTATHIONE REDUCED,L-GLUTATHIONE (REDUCED FORM) Thiamine disulfide GLUTATHIONE PEROXIDASE S-LACTOYL-GLUTATHIONE METHYLGLYOXAL-LYASE [ISOMERIZING] NAD[P]H: OXIDIZED-GLUTATHIONE OXIDOREDUCTASE TYPE II,NAD[P]H: OXIDIZED-GLUTATHIONE OXIDOREDUCTASE,NAD[P]H: OXIDIZED-GLUTATHIONE OXIDOREDUCTASE TYPE VI L-GLUTATHIONE OXIDIZED,L-GLUTATHIONE (OXIDIZED FORM),L-GLUTATHIONE OXIDISED,GSSG L-GLUTATHIONE OXIDIZED DISODIUM SALT,GSSG DISODIUM SALT,GSSG , OXIDIZED FORM DISODIUM SALT S-NITROSO-L-GLUTATHIONE RX: GLUTATHIONE R-TRANSFERASE S-(LACTOYL)GLUTATHIONE N,S-BIS-FMOC-GLUTATHIONE L-Glutathione L-CYSTEINE-GLUTATHIONE DISULFIDE,L-CYSTEINE-GLUTATHIONE DISULPHIDE GGKPDLRPCHPPCHYIPRPKPR ([15N]GLY)-GLUTATHIONE (REDUCED) S-(1-PENTYL-5-BIOTINYLAMIDO)GLUTATHIONE S-(N,N-DIETHYLCARBAMOYL)GLUTATHIONE S-LINKED GLUTATHIONE AGAROSE,GLUTATHIONE-UNIFLOW RESIN,GLUTATHIONE-SUPERFLOW RESIN

NOV-002

White lyophilizate

L-Glutathione oxidized Vetec(TM) reagent grade, >=98%

Glutathione(Oxidized Form), free acid

n-(n-gamma-glutamyl-cysteinyl)glycine-(2,2)-disulfide

N,N’-[dithiobis[1-[(carboxymethyl)carbamoyl]ethylene]]di-,L-Glutamine

n’-(dithiobis(1-((carboxymethyl)carbamoyl)ethylene))di-l-glutamin

oxidizedglutathione

oxigluthione

S,S’-Ethylenebis(glutathione)

L-.GLUTATHIONE (OXIDIZED) [N-(N-L-G-GLUTAMYL-L-CYSTEINYL)GLYCINE]

GLUTATHIONE OXIDISED extrapure

glutathione, oxidised

Glutathiol, GSSG

L-Glutathione oxidized, Glutathiol, GSSG

3,3'-Dithiobis[N-(carboxymethyl)-N2-(γ-glutamyl)alaninamide]

N,N'-Bis(carboxymethyl)-Nα,Nα'-bis(γ-glutamyl)-L-cystinamide

Oxyglutatione

l-gamma-glutamyl-l-cysteinyl glycine

L(-)-Glutathione, oxidized, hydrate,98+%

L(-)-Glutathione, oxidized, hydrate,95%

L(-)-Glutathione, oxidized,98%

L-Glutathione oxidized,GSSG, Glutathiol

()-Glutathione, oxidized,L-Glutathione oxidized, GSSG, Glutathiol

Glutathione Oxydized

L(-)-Glutathionehydrate

L(-)-Glutathione

L(-)-Glutathione, oxidized, 98% 500MG

N,N'-[Dithiobis[1-[(carboxyMethyl)carbaMoyl]ethylene]]diglutaMine

GLT1JP-IN (L-GLUTATHIONE RED

Glutathione IMpurity C (Disulfide IMpurity)

L-Glutathione (oxidized) L-Glutathione (oxidized)

glutathionedisulphide

glutathione-ssg

glutathonedisulfide

Glycine,L-.gamma.-glutamyl-L-cysteinyl-,2,2’-disulfide

glycine,l-gamma-glutamyl-l-cysteinyl-,(2,2’)-disulfide

l-oxidizedglutathione

N-(N-.gamma.-Glutamyl-cysteinyl)glycine-2,2-disulfide

Glutathiol

Oxiglutatione

L-GLUTATHIONE OXIDISED

L-GLUTATHIONE OXIDIZED

L-GLUTATHIONE (OXIDIZED FORM)

GSSC

GSSG

(GAMMA-GLU-CYS-GLY)2

[GAMMA-GLU-CYS-GLY] [GAMMA-GLU-CYS-GLY]

GAMMA-L-GLUTAMYL-L-CYSTEINYLGLYCINE OXIDIZED

(-)-GLUTATHIONE, OXIDIZED

GLUTATHIONE DISULFIDE

GLUTATHIONE, OXIDIZED FORM

CYCLIC(GAMMA-GLU-CYS-GLY)

CYCLIC(GAMMA-GLU-CYS-GLY)2

bi(glutathion-S-yl)

GLUTATHIONE OXIDIZED FORM FREE ACID*LYOP HILIZED POW

** APPROVAL REQ **GLUTATHIONE OXIDIZED

GLUTATHIONE OXIDIZED FORM FREE ACID*GRAD E II