Thiamine disulfide

Product Name: Thiamine disulfide
CAS No.: 67-16-3
Chemical Name: Thiamine disulfide
Synonyms: TDS;SSB1;Daiomin;Apren S;Daisazin;Neolamin;Alitia S;FeidMin 5;BISTHIAMINE;Algoneurina
CBNumber: CB9722783
Molecular Formula: C24H34N8O4S2
Formula Weight: 562.71
MOL File: 67-16-3.mol

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Thiamine disulfide Property

Melting point:: 177° with intense yellow coloration
Boiling point:: 886.1±65.0 °C(Predicted)
Density: 1.1966 (rough estimate)
refractive index: 1.7400 (estimate)
storage temp.: Refrigerator
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 14.10±0.10(Predicted)
form: Solid
color: White
Merck: 14,9297
CAS DataBase Reference: 67-16-3(CAS DataBase Reference)
EPA Substance Registry System: Formamide, N,N'-[dithiobis[2-(2-hydroxyethyl)-1-methyl-2,1-ethenediyl]]bis[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]- (67-16-3)

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Safety

RTECS: LQ2715000
HS Code: 2936.22.0000
Toxicity: LD50 intravenous in mouse: 500mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T0176
Product name: Thiamine Disulfide Hydrate
Purity: >98.0%(T)
Packaging: 25g
Price: $146
Updated: 2024/03/01

TRC

Product number: T344278
Product name: ThiamineDisulfide
Packaging: 2.5g
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: J50009
Product name: Thiaminedisulfide
Packaging: 25g
Price: $120
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0004386
Product name: THIAMINE DISULFIDE
Purity: 95.00%
Packaging: 25G
Price: $210.11
Updated: 2021/12/16

AK Scientific

Product number: P052
Product name: Thiaminedisulfide
Packaging: 100g
Price: $481
Updated: 2021/12/16

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Thiamine disulfide Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Arcalion,Servier,France,1974

Uses

Thiamine is a essential nutrient required for carbohydrate metabolism; also involved in nerve function. Biosynthesized by microorganisms and plants. Dietary sources include whole grains, meat products , vegetables, milk, legumes and fruit. Also present in rice husks and yeast. Converted in vivo to Thiamine diphosphate, a coenzyme in the decarboxylation of α-keto acids. Chronic deficiency may lead t o neurological impairment, bariberi, Wernicke-Korsakoff syndrome.

Uses

Thiamine disulfide is an antioxidant, inhibiting lipid peroxidation in rat liver microsomes and free radical oxidation of oleic acid in vitro. Thiamine disulfide has been explored as a potent inhibitor of HIV-1.

Definition

ChEBI: Thiamine disulfide is an aminopyrimidine, a homoallylic alcohol, a member of formamides and an organic disulfide.

Manufacturing Process

20 parts by weight of thiamin are dissolved in 25 parts of water, a cold solution of 5 parts by weight of caustic soda in 25 parts of water added and the mixture oxidized with a solution of 2.4 parts by weight of caustic soda and 20 parts by weight of potassium ferric cyanide in 80 parts of water while stirring in the cold. The liquid is then evaporated to dryness and the resulting oxidation product extracted with warm butyl alcohol.
The butyl-alcoholic solution is evaporated in vacuo and the residue dissolved with gentle heating in 25 parts by volume of methyl alcohol. 100 parts by volume of acetone are added, the solution filtered and further quantities of acetone added, whereupon crystallization sets in. Yield: 12.2 parts by weight of the pure product, having the melting point 177° to 179°C.

Therapeutic Function

Enzyme cofactor vitamin

Biological Activity

Thiamine Disulfide can be reduced by glutathione and thioredoxin (Trx) systems. In Caco-2 cells, thiamine disulfide derivatives did not alter the total thiol content, but it was significantly reduced by simultaneous inhibition of TrxR. When oxidative stress was induced by tert-butyl hydroperoxide, thiamine disulfide exerted a protective effect, indicating that the thiol form generated by disulfide reduction may be the active species. In addition, thiamine disulfide was shown to increase the nuclear levels of the transcription factor nuclear factor erythroid 2-related factor 2, and stimulate the expression and activity of NAD(P)H quinone dehydrogenase 1 and TrxR. However, other enzymes of the glutathione and Trx systems were barely affected^[1].

References

[1] FOLDA A, SCALCON V, TONOLO F, et al. Thiamine disulfide derivatives in thiol redox regulation: Role of thioredoxin and glutathione systems[J]. BioFactors, 2024, 3 1. DOI:10.1002/biof.2121.

Thiamine disulfide Preparation Products And Raw materials

Raw materials

Preparation Products

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Thiamine disulfide Suppliers

Canada 1 China 125 France 1 Germany 3 India 8 Indonesia 1 Ireland 1 Japan 3 South Korea 1 The Netherlands 1 United Kingdom 9 United States 20 Venezuela 1 Global 175

Shangqiu Ladybug Network Technology Co., LTD

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J & K SCIENTIFIC LTD.

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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
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Energy Chemical

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Country: China
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Sichuan Kulinan Technology Co., Ltd

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Maya High Purity Chemicals

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Chengdu Ai Keda Chemical Technology Co., Ltd.

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Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
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Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
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View Lastest Price from Thiamine disulfide manufacturers

Career Henan Chemical Co

Product: Thiamine disulfide 67-16-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100kg
Release date: 2019-05-23

67-16-3, Thiamine disulfideRelated Search:

Hydroxyethyl Cellulose 2-(2-Aminoethylamino)ethanol Methyl cellulose Thiamine hydrochloride Tetramethylthiuram Disulfide Benfotiamine Sodium isethionate Methyl 2-hydroxyethyl cellulose Thiamine chloride Methanol TITANIUM(IV) SULFIDE Diallyldisulfide Tris(hydroxymethyl)aminomethane Kresoxim-methyl Molybdenum disulfide Methylparaben Methyl acrylate Bensulfuron methyl

4-amino-2-methyl-5-pyrimidinyl)methyl]-

formamide,n,n’-[dithiobis[2-(2-hydroxyethyl)-1-methyl-2,1-ethenediyl]]bis[n-[(

ANEURINE DISULFIDE

THIAMINE DISULFIDE

BISTHIAMINE

n,n'-(dithiobis(2-(2-hydroxyethyl)-1-methyl-2,1-ethenediyl))bis(n-((4-amino-2-methyl-5-pyrimidinyl)methyl)formamide

TDS

N,N'-[dithiobis[2-(2-hydroxyethyl)-1-methylvinylene]]bis[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]formamide

THIAMINE DISULFIDE(TDS)

Vitamin B1 disulfide (Thiamine disulfide)

Aneurin disulfide

Daiomin

Daisazin

Neolamin

N,N'-Dithiobis[4-hydroxy-1-methyl-1-butene-2,1-diyl]bis[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]formamide]

Algoneurina

Einecs 200-644-4

N,N'-(Dithiobis(2-(2-hydroxyethyl)-1-methylvinylene))bis(N-((4-amino-2-methyl-5-pyrimidinyl)methyl)formamide)

2,1-ethenediyl))bis(N-((4-amino-2-methyl-5-pyrimidinyl)methyl)formamide

Alitia S

Apren S

FeidMin 5

SSB1

ThiaMidin F

ThiaMin Disulfide

ThiaMine Disulfide&nbsp

Formamide, N,N-dithiobis2-(2-hydroxyethyl)-1-methyl-2,1-ethenediylbisN-(4-amino-2-methyl-5-pyrimidinyl)methyl-

Thiamine Disulfide Hydrate

N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-N-[(E)-3-[[(E)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-hydroxypent-2-en-3-yl]disulfanyl]-5-hydroxypent-2-en-2-yl]formamide

Thiamine Impurity 12（Thiamine Disulfide）

N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[(E)-3-[[(E)-2-[(4-amino-2-methyl-5-pyrimidinyl)methyl-formylamino]-5-hydroxypent-2-en-3-yl]disulfanyl]-5-hydroxypent-2-en-2-yl]formamide

Thiamine Disulfide Hydrate&gt

N,N'-(disulfanediylbis(5-hydroxypent-2-ene-3,2-diyl))bis(N-((4-amino-2-methylpyrimidin-5-yl)methyl)formamide)

N-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-N-[3-[[2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-hydroxypent-2-en-3-yl]disulfanyl]-5-hydroxypent-2-en-2-yl]formamide

Vitamin B1 Impurity 10

67-16-3

C24H34N8O4S2

C24H34N8O4S2xH2O

C24H34N8O4S2H2O

Vitamins and derivatives

Biochemistry

Vitamin Derivatives

Vitamins